Single-Column Simulated Moving-Bed Process with Recycle Lag: Analysis and Applications

Autor: João M.M. Araújo, Rui C.R. Rodrigues, Ricardo J.S. Silva, José P.B. Mota

Publikováno v: Adsorption Science & Technology, Vol 25 (2007)

We report some conceptual and numerical results for a single-column chromatographic process analogous to a simulated moving bed (SMB) with asynchronous port switching. It is shown that the periodic state of the multi-column SMB unit is reproduced by

Externí odkaz: https://doaj.org/article/594d0757711c4cae9e93cf3f498e3f82

Exosome-based therapeutics: Purification using semi-continuous multi-column chromatography

Autor: Manuel J.T. Carrondo, Ricardo J.S. Silva, Paula M. Alves, Mafalda G. Moleirinho, Cristina Peixoto

Publikováno v: Separation and Purification Technology. 224:515-523

Extracellular vesicles, more particularly exosomes, are nanostructures of great medical interest. Similarly to other complex biopharmaceuticals such as virus, the purification of these nanovesicles is still a considerable challenge. Here we describe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba61ad71dc23a7d413a1e3280d70a899
https://doi.org/10.1016/j.seppur.2019.04.060

Downstream processing for influenza vaccines and candidates: An update

Autor: Ricardo J.S. Silva, Manuel J.T. Carrondo, Cristina Peixoto, Sofia B. Carvalho

Publikováno v: Biotechnology and bioengineeringREFERENCES. 118(8)

Seasonal and pandemic influenza outbreaks present severe health and economic burdens. To overcome limitations on influenza vaccines' availability and effectiveness, researchers chase universal vaccines providing broad, long-lasting protection against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5fb458893ec1b6509c5914c001cb711
https://pubmed.ncbi.nlm.nih.gov/33913510

A Sensitive Method Approach for Chromatographic Analysis of Gas Streams in Separation Processes Based on Columns Packed with an Adsorbent Material

Autor: Mário Eusébio, Ricardo J.S. Silva, G. M. R. P. L. Sousa, Rui P. P. L. Ribeiro, Isabel A. A. C. Esteves, José P. B. Mota

Publikováno v: Advances in Materials Science and Engineering, Vol 2016 (2016)

A sensitive method was developed and experimentally validated for the in-line analysis and quantification of gaseous feed and product streams of separation processes under research and development based on column chromatography. The analysis uses a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd21e5d4a3148fa97a61082e51c02459
https://doi.org/10.1155/2016/3216267

Clinical-grade oncolytic adenovirus purification using polysorbate 20 as an alternative for cell lysis

Autor: Gustaf Ahlén, Sara Rosa, Ricardo J.S. Silva, Mats Lundgren, Mafalda G. Moleirinho, Cristina Peixoto, Paula M. Alves, Åsa Hagner-McWhirter, Manuel J.T. Carrondo

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Current Gene Therapy

PD/BD/114034/2015 Introduction: Oncolytic virus therapy is currently considered as a promising therapeutic approach for cancer treatment. Adenovirus is well-known and extensively characterized as an oncolytic agent. The increasing number of clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561c6fea36ac68425d9a3b507dd81d07
http://www.scopus.com/inward/record.url?scp=85058877688&partnerID=8YFLogxK