Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ricardo J. S. Silva"'
Autor:
Sónia Mendes, Tiago Q. Faria, André Nascimento, Marc Noverraz, Franziska Bollmann, Piergiuseppe Nestola, António Roldão, Cristina Peixoto, Ricardo J. S. Silva
Publikováno v:
Separations, Vol 11, Iss 3, p 73 (2024)
Adeno-associated viruses (AAV) are currently predominant viral transfer tools for gene therapy, and efforts are being made to design faster and more efficient methods and technologies for their manufacturing. The early selection of high-performing fi
Externí odkaz:
https://doaj.org/article/6cdce523228341529b56a6e926a4ca43
Autor:
Salomé Neto, João P. Mendes, Susana B. Dos Santos, Anita Solbrand, Manuel J. T. Carrondo, Cristina Peixoto, Ricardo J. S. Silva
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Adeno-associated viruses (AAVs) are one of the most promising tools for gene therapy applications. These vectors are purified using affinity and ion exchange chromatography, typically using packed beds of resin adsorbents. This leads to diffusion and
Externí odkaz:
https://doaj.org/article/4d2723ec4e3c42c1b83ac42378534e38
Autor:
João P. Mendes, Bárbara Fernandes, Earl Pineda, Shashi Kudugunti, Mike Bransby, René Gantier, Cristina Peixoto, Paula M. Alves, António Roldão, Ricardo J. S. Silva
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Adeno-associated viruses (AAVs) demand for clinical trials and approved therapeutic applications is increasing due to this vector’s overall success and potential. The high doses associated with administration strategies challenges bioprocess engine
Externí odkaz:
https://doaj.org/article/eb6e26dfbfb0422c8be339d3785d3d01
Autor:
Mariana V. Ferreira, Sofia Fernandes, Ana Isabel Almeida, Salomé Neto, João P. Mendes, Ricardo J. S. Silva, Cristina Peixoto, Ana Sofia Coroadinha
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10524 (2023)
Adeno-associated viral (AAV) vectors represent one of the leading platforms for gene delivery. Nevertheless, their small packaging capacity restricts their use for diseases requiring large-gene delivery. To overcome this, dual-AAV vector systems that
Externí odkaz:
https://doaj.org/article/36e289fa08f7437a8e82a2bfb54094fa
Autor:
Sofia B. Carvalho, Ricardo J. S. Silva, Marcos F. Q. Sousa, Cristina Peixoto, António Roldão, Manuel J. T. Carrondo, Paula M. Alves
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Virus-like particles (VLPs) are excellent platforms for the development of influenza vaccine candidates. Nonetheless, their characterization is challenging due to VLPs’ unique biophysical and biochemical properties. To cope with such complexity, mu
Externí odkaz:
https://doaj.org/article/1941adabf729446ab0a5d18b8aee6648
Autor:
Rita P. Fernandes, José M. Escandell, Ana C. L. Guerreiro, Filipa Moura, Tiago Q. Faria, Sofia B. Carvalho, Ricardo J. S. Silva, Patrícia Gomes-Alves, Cristina Peixoto
Publikováno v:
Viruses, Vol 14, Iss 11, p 2539 (2022)
Virus-based biopharmaceutical products are used in clinical applications such as vaccines, gene therapy, and immunotherapy. However, their manufacturing remains a challenge, hampered by the lack of appropriate analytical tools for purification monito
Externí odkaz:
https://doaj.org/article/34eeeaa2f31843eba04fb9eeedc9f1a4
Autor:
João P. Mendes, Magnus Bergman, Anita Solbrand, Cristina Peixoto, Manuel J. T. Carrondo, Ricardo J. S. Silva
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1346 (2022)
Replacing batch unit operations of biopharmaceuticals by continuous manufacturing is a maturing concept, with periodic counter-current chromatography (PCC) favoured to replace batch chromatography. Continuous affinity capture of adeno-associated viru
Externí odkaz:
https://doaj.org/article/af19056809b94de4ba6fd2a19c130678
Autor:
Coroadinha, Mariana V. Ferreira, Sofia Fernandes, Ana Isabel Almeida, Salomé Neto, João P. Mendes, Ricardo J. S. Silva, Cristina Peixoto, Ana Sofia
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 10524
Adeno-associated viral (AAV) vectors represent one of the leading platforms for gene delivery. Nevertheless, their small packaging capacity restricts their use for diseases requiring large-gene delivery. To overcome this, dual-AAV vector systems that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::55317188477abda2c493459e5e63bbe5
Autor:
José Escandell, Filipa Moura, Sofia B. Carvalho, Ricardo J. S. Silva, Ricardo Correia, Antonio Roldão, Patrícia Gomes‐Alves, Paula M. Alves
Publikováno v:
Biotechnology and Bioengineering.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0231d7415f4e4cd89d39853141fce8e4
https://doi.org/10.1002/bit.28394
https://doi.org/10.1002/bit.28394
Autor:
Sofia B. Carvalho, Ricardo J. S. Silva, Marcos F. Q. Sousa, Cristina Peixoto, António Roldão, Manuel J. T. Carrondo, Paula M. Alves
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Virus-like particles (VLPs) are excellent platforms for the development of influenza vaccine candidates. Nonetheless, their characterization is challenging due to VLPs’ unique biophysical and biochemical properties. To cope with such complexity, mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd5ef5d7cf9fa07bf022769ebf181c3
https://pubmed.ncbi.nlm.nih.gov/35252128
https://pubmed.ncbi.nlm.nih.gov/35252128