Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Ricardo J. Ferreira"'
Autor:
Ricardo J. Ferreira, Mariana A. Reis, Daniel Silva, Elisandra Scapin, Saikat Dewanjee, Marta P. Carrasco
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/9558252193db42faa37837aef975353d
Autor:
Gabrielle Bangay, Vera M. S. Isca, Daniel J. V. A. Dos Santos, Ricardo J. Ferreira, Salvatore Princiotto, Mirna Jovanovic, Milica Pesic, Patricia Rijo
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 144 (2022)
The number of multidrug resistant (MDR) cancer cases across the globe is continuing to rise, such that the search for novel anti-cancer therapeutics is paramount. For instance, the overexpression of membrane transport proteins, such as P-glycoprotein
Externí odkaz:
https://doaj.org/article/9b2a6d2d23a74118b2312c6e8664c92f
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Tuberculosis is an highly contagious disease still considered by the WHO as one of most infectious diseases worldwide. The therapeutic approach, used to prevent and treat tuberculosis targets the Mycobacterium tuberculosis complex, comprises a combin
Externí odkaz:
https://doaj.org/article/9286cb61f8d140209a43858d789f551a
Autor:
Catarina Garcia, Vera M. S. Isca, Filipe Pereira, Carlos M. Monteiro, Epole Ntungwe, Francisco Sousa, Jelena Dinic, Suvi Holmstedt, Amílcar Roberto, Ana Díaz-Lanza, Catarina P. Reis, Milica Pesic, Nuno R. Candeias, Ricardo J. Ferreira, Noélia Duarte, Carlos A. M. Afonso, Patrícia Rijo
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Cancer is among the leading causes of death worldwide. One of the most challenging obstacles in cancer treatment is multidrug resistance (MDR). Overexpression of P-glycoprotein (P-gp) is associated with MDR. The growing incidence of cancer and the de
Externí odkaz:
https://doaj.org/article/e0c57d17a6814473b2b968463276ad86
Autor:
Mariana Alves Reis, Ana M. Matos, Noélia Duarte, Omar Bauomy Ahmed, Ricardo J. Ferreira, Hermann Lage, Maria-José U. Ferreira
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
BackgroundMultidrug resistance (MDR) has been regarded as one of the major hurdles for the successful outcome of cancer chemotherapy. The collateral sensitivity (CS) effect is one the most auspicious anti-MDR strategies. Epoxylathyrane derivatives 1
Externí odkaz:
https://doaj.org/article/6dd53d3c33e74363b78dd0e995b72701
Autor:
Cátia A. Bonito, Ricardo J. Ferreira, Maria-José. U. Ferreira, Fernando Durães, Emília Sousa, Jean-Pierre Gillet, M. Natália D. S. Cordeiro, Daniel J. V. A. dos Santos
Publikováno v:
ACS Omega. 8:11281-11287
A medicinal chemistry approach combining in silico and in vitro methodologies was performed aiming at identifying and characterizing putative allosteric drug-binding sites (aDBSs) at the interface of the transmembrane- and nucleotide-binding domains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38a37d86ec5825370ad57642ffedd7a
https://doi.org/10.1021/acsomega.2c08273
https://doi.org/10.1021/acsomega.2c08273
Autor:
Cátia A. Bonito, Ricardo J. Ferreira, Maria-José.U. Ferreira, Jean-Pierre Gillet, M. Natália D. S. Cordeiro, Daniel J. V. A. dos Santos
Publikováno v:
Journal of Biomolecular Structure and Dynamics. :1-10
The modulation of drug efflux by P-glycoprotein (P-gp, ABCB1) represents one of the most promising approaches to overcome multidrug resistance (MDR) in cancer cells, however the mechanisms of drug specificity and signal-transmission are still poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38fd2bfe0c7f124b657fe3ee6e0a433
https://doi.org/10.1080/07391102.2023.2181633
https://doi.org/10.1080/07391102.2023.2181633
Autor:
Cátia A. Bonito, Ricardo J. Ferreira, Maria-José. U. Ferreira, Fernando Durães, Emília Sousa, Jean-Pierre Gillet, Maria Natália Cordeiro, Daniel J. V. A. dos Santos
A medicinal chemistry approach combining in silico and in vitro methodologies was performed aiming at identifying and characterizing putative allosteric drug-binding sites (aDBS) at the interface of the transmembrane- and nucleotide-binding domains (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ceb6f6c65b02e3712bb1cedfc3f250a
https://doi.org/10.21203/rs.3.rs-2038969/v1
https://doi.org/10.21203/rs.3.rs-2038969/v1
Autor:
Catarina A. Madeira, Carolina Anselmo, João M. Costa, Cátia A. Bonito, Ricardo J. Ferreira, Daniel J.V.A. Santos, Ronald Wanders, João B. Vicente, Fátima V. Ventura, Paula Leandro
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. :166766
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa9e9177c1d66367ecb1ff69e516d522
https://doi.org/10.1016/j.bbadis.2023.166766
https://doi.org/10.1016/j.bbadis.2023.166766
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 39:4752-4763
P-glycoprotein (P-gp) is a key efflux pump involved in cellular multidrug resistance (MDR), lowering the concentration of many anticancer drugs in tumor cells by pumping them into the extracellular milieu. While previous studies identified 1,4-dihydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c93de736d88f18960c359754f456b7
https://doi.org/10.1080/07391102.2020.1780942
https://doi.org/10.1080/07391102.2020.1780942