Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Ricardo J Nunes"'
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Akademický článek
SB225002 Induces Cell Death and Cell Cycle Arrest in Acute Lymphoblastic Leukemia Cells through the Activation of GLIPR1.
Autor: Jaíra Ferreira de Vasconcellos, Angelo Brunelli Albertoni Laranjeira, Paulo C Leal, Manoj K Bhasin, Priscila Pini Zenatti, Ricardo J Nunes, Rosendo A Yunes, Alexandre E Nowill, Towia A Libermann, Luiz Fernando Zerbini, José Andrés Yunes
Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0134783 (2015)
Acute Lymphoblastic Leukemia (ALL) is the most frequent childhood malignancy. In the effort to find new anti-leukemic agents, we evaluated the small drug SB225002 (N-(2-hydroxy-4-nitrophenyl)-N'-(2-bromophenyl)urea). Although initially described as a
Externí odkaz: https://doaj.org/article/e9843bd459894264bbf568c153565b4f
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3
Pyrazolines as potential anti-Alzheimer's agents: DFT, molecular docking, enzyme inhibition and pharmacokinetic studies
Autor: Valkiria Machado, Arthur R. Cenci, Kerolain F. Teixeira, Larissa Sens, Tiago Tizziani, Ricardo J. Nunes, Leonardo L. G. Ferreira, Rosendo A. Yunes, Louis P. Sandjo, Adriano D. Andricopulo, Aldo S. de Oliveira
Publikováno v: RSC Medicinal Chemistry. 13:1644-1656
Alzheimer's disease (AD) is a neurodegenerative disease that is characterized as the main dementia in the elderly. Eighteen pyrazolines were synthesized and evaluated for their inhibitory effects against acetylcholinesterase (AChE)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf56128e2c47ab5661faa45e09d9571c
https://doi.org/10.1039/d2md00262k
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4
Novel trypanocidal thiophen-chalcone cruzain inhibitors: structure- and ligand-based studies
Autor: Aldo S de Oliveira, Marilia Valli, Leonardo LG Ferreira, Julia M Souza, Renata Krogh, Lidiane Meier, Heitor R Abreu, Bruna G Voltolini, Luana C Llanes, Ricardo J Nunes, Antonio L Braga, Adriano D Andricopulo
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Background: Chagas disease is a neglected tropical disease that affects millions of people worldwide and for which no effective treatment is available. Materials & methods: 17 chalcones were synthesized, for which the inhibition of cruzain and trypan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2f14ca3d83d635603d5e26c703640e
https://pubmed.ncbi.nlm.nih.gov/35543430
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Antioxidant Activity, Molecular Docking, Quantum Studies and In Vivo Antinociceptive Activity of Sulfonamides Derived From Carvacrol
Autor: Aldo S. de Oliveira, Luana C. Llanes, Ricardo J. Nunes, Catharina Nucci-Martins, Anacleto S. de Souza, David L. Palomino-Salcedo, María J. Dávila-Rodríguez, Leonardo L. G. Ferreira, Adair R. S. Santos, Adriano D. Andricopulo
Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
The synthesis and antioxidant, antinociceptive and antiedematogenic activities of sulfonamides derived from carvacrol—a druglike natural product—are reported. The compounds showed promising antioxidant activity, and sulfonamide derived from morph
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e696d49fdda6a29b78737db26f0367
https://www.frontiersin.org/articles/10.3389/fphar.2021.788850/full
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Sulfated β-glucan from Agaricus subrufescens inhibits flavivirus infection and nonstructural protein 1-mediated pathogenesis
Autor: Francielle Tramontini Gomes de Sousa, Scott B. Biering, Trishna S. Patel, Sophie F. Blanc, Carla M. Camelini, Dalila Venzke, Ricardo J. Nunes, Camila M. Romano, P. Robert Beatty, Ester C. Sabino, Eva Harris
Publikováno v: Antiviral Research. 203:105330
Despite substantial morbidity and mortality, no therapeutic agents exist for treatment of dengue or Zika, and the currently available dengue vaccine is only recommended for dengue virus (DENV)-immune individuals. Thus, development of therapeutic and/
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82aba4de702813d4b2b603b1f0a4958a
https://doi.org/10.1016/j.antiviral.2022.105330
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In vitro and in silico Approaches to the Identification of New Compounds with Antibacterial Profile
Autor: Carlos R. Rodrigues, Bruno Leal, Kely N. De Oliveira, Ariane S. S. R. Ferreira, Alice Bernardino, Ricardo J. Nunes, Vitor Ferreira, Maria C. De Souza, Anna C. Cunha, Helena C. Castro
Publikováno v: Journal of Systemics, Cybernetics and Informatics, Vol 11, Iss 3, Pp 62-65 (2013)
The emergence of multidrug-resistant bacterial strains is a world problem that increases the need for new and more effective antimicrobials. On that purpose, derivatives of cyclic systems may serve as new leads for discovering new active molecules. I
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5141d47172f2cc99ff9ae67f0b4e1bd5
http://www.iiisci.org/Journal/CV$/sci/pdfs/8BA798EF.pdf
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8
Activity of novel quinoxaline-derived chalcones on in vitro glioma cell proliferation
Autor: Tânia R, Mielcke, Alessandra, Mascarello, Eduardo, Filippi-Chiela, Rafael F, Zanin, Guido, Lenz, Paulo César, Leal, Louise Domeneghini, Chiaradia, Louise D, Chirardia, Rosendo A, Yunes, Ricardo J, Nunes, Ana M O, Battastini, Fernanda B, Morrone, Maria M, Campos
Publikováno v: European Journal of Medicinal Chemistry. 48:255-264
Gliomas are the most common and devastating tumors of the central nervous system (CNS). Many pieces of evidence point out the relevance of natural compounds for cancer therapy and prevention, including chalcones. In the present study, eight synthetic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8e2eea3939d81c87add9de010ac266
https://doi.org/10.1016/j.ejmech.2011.12.023
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Aspectos químicos e potencial terapêutico de imidas cíclicas: uma revisão da literatura Chemical aspects and therapeutic potential of cyclic imides: a review
Autor: Valdir Cechinel Filho, Fátima de Campos, Rogério Corrêa, Rosendo A. Yunes, Ricardo J. Nunes
Publikováno v: Química Nova, Vol 26, Iss 2, Pp 230-241 (2003)
Cyclic imides consists of an important family of organic compounds with therapeutic potential. In this review, emphasis will be given to the chemical and biological aspects of several sub-classes of this family, incluing maleimides, succinimides, glu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::47eb7e289d9e8292595fa7c1b091d805
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000200016
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Avaliação da sensibilidade de cepas de Malassezia furfur a imidas cíclicas Sensibility of evaluations of Malassezia furfur strains at cyclic imides
Autor: Edeltrudes de Oliveira Lima, Lindomar F Belém, Valdir Cechinel Filho, Rogério Corrêa, Ricardo J Nunes, Adriano Andricopulo, Victor E. da Silva
Publikováno v: Revista Brasileira de Ciências Farmacêuticas, Vol 38, Iss 4, Pp 443-450 (2002)
Malassezia furfur (Pityrosporum orbiculare) é um fungo lipofílico, que está associado a pitiríase versicolor, foliculite, dermatite seborréica e atópica, fungemia e infecções sistêmicas. O tratamento é feito com soluções antimicóticas ou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::c82c8eb1cce5ec2ba1df3af575c844d6
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-93322002000400006
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