Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Ricardo J Miragaia"'
Autor:
Matthias Pfeifer, Jonathan S. Brammeld, Stacey Price, James Pilling, Deepa Bhavsar, Anca Farcas, Jessica Bateson, Anjana Sundarrajan, Ricardo J. Miragaia, Nin Guan, Stephanie Arnold, Laiba Tariq, Michael Grondine, Sarah Talbot, Maria Lisa Guerriero, Daniel J. O’Neill, Jamie Young, Carlos Company, Shanade Dunn, Hannah Thorpe, Matthew J. Martin, Kimberly Maratea, Daniel Barrell, Miika Ahdesmaki, Jerome T. Mettetal, Functional Genomics Centre, James Brownell, Ultan McDermott
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Most lung cancer patients with metastatic cancer eventually relapse with drug-resistant disease following treatment and EGFR mutant lung cancer is no exception. Genome-wide CRISPR screens, to either knock out or overexpress all protein-codin
Externí odkaz:
https://doaj.org/article/ed715ab2efbd4a99b27d7f1bbae4d95d
Autor:
Steven W. Criscione, Matthew J. Martin, Derek B. Oien, Aparna Gorthi, Ricardo J. Miragaia, Jingwen Zhang, Huawei Chen, Daniel L. Karl, Kerrin Mendler, Aleksandra Markovets, Sladjana Gagrica, Oona Delpuech, Jonathan R. Dry, Michael Grondine, Maureen M. Hattersley, Jelena Urosevic, Nicolas Floc’h, Lisa Drew, Yi Yao, Paul D. Smith
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-13 (2022)
Abstract Third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs), including osimertinib, an irreversible EGFR-TKI, are important treatments for non-small cell lung cancer with EGFR-TKI sensitizing or EGFR T790M resistance mutations. While patien
Externí odkaz:
https://doaj.org/article/d7852854a3ba43459578c3fb424140e2
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
ATAC-seq is widely used to identify regulatory regions in the genome. Here the authors develop a simple and robust plate-based single-cell ATAC-seq method that works in fresh and cryopreserved cells.
Externí odkaz:
https://doaj.org/article/4f8114e572994fd2b334a80d5dbcfc5c
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Marker genes for the monocyte-macrophage-DC subpopulations identified in Supplementary Figure 5H. Only genes with adjusted p-value < 0.01 and average log fold-change > 0.3 were included. gene, gene name; p_val, p-value calculated based on Wilcoxon te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318ab2f876a4f6d65d1cc34e89e50b21
https://doi.org/10.1158/2159-8290.22540394
https://doi.org/10.1158/2159-8290.22540394
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Pharmacodynamics of STAT3 ASO in CT26 STK11 KO model. (A) Percentage of CD45+ immune cells among live cells from untreated or drug-treated STK11 KO CT26 tumors as indicated. (B) Percentage of Ly6G+ granulocytic cells among live CD45+ cells. (C) Perce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c1f0437b345d54961ba0824610dcb6
https://doi.org/10.1158/2159-8290.22540439.v1
https://doi.org/10.1158/2159-8290.22540439.v1
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Supplementary Appendix
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ac7dc7f83ade0389ea5b8926dfead1
https://doi.org/10.1158/2159-8290.22540454.v1
https://doi.org/10.1158/2159-8290.22540454.v1
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Mutations in the STK11 (LKB1) gene regulate resistance to PD-1/PD-L1 blockade. This study evaluated this association in patients with nonsquamous non–small cell lung cancer (NSCLC) enrolled in three phase I/II trials. STK11 mutations were associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99faa4f93ebec463e8a33a4c093c1abb
https://doi.org/10.1158/2159-8290.c.6549368.v1
https://doi.org/10.1158/2159-8290.c.6549368.v1
Autor:
Mélanie A. Eckersley-Maslin, Valentine Svensson, Christel Krueger, Thomas M. Stubbs, Pascal Giehr, Felix Krueger, Ricardo J. Miragaia, Charalampos Kyriakopoulos, Rebecca V. Berrens, Inês Milagre, Jörn Walter, Sarah A. Teichmann, Wolf Reik
Publikováno v:
Cell Reports, Vol 17, Iss 1, Pp 179-192 (2016)
Mouse embryonic stem cells are dynamic and heterogeneous. For example, rare cells cycle through a state characterized by decondensed chromatin and expression of transcripts, including the Zscan4 cluster and MERVL endogenous retrovirus, which are usua
Externí odkaz:
https://doaj.org/article/feffc699cc1445659a80967f50cbb71b
Autor:
Yashaswi Shrestha, Ronald Herbst, Rajiv Raja, Maria Libera Ascierto, Michael Oberst, Philip Martin, Melissa de los Reyes, Nabendu Pore, Raymond Rothstein, John Meekin, Ashok K. Gupta, Melanie M. Frigault, Stephen Blackmore, Ina Bisha, Nathan Standifer, Shaad Essa Abdullah, Theresa Proia, Matthew Griffin, Phillip A. Dennis, Rebecca A. Halpin, Song Wu, Ricardo J Miragaia, Kathy Mulgrew, J. Carl Barrett, Maria Jure-Kunkel
Publikováno v:
Cancer Discovery. 11:2828-2845
Mutations in the STK11 (LKB1) gene regulate resistance to PD-1/PD-L1 blockade. This study evaluated this association in patients with nonsquamous non–small cell lung cancer (NSCLC) enrolled in three phase I/II trials. STK11 mutations were associate
Autor:
Felipe A. Vieira Braga, James Fletcher, Tomás Gomes, Raghd Rostom, Sarah A. Teichmann, Ivanela Kondova, Xi Chen, Michael Lässig, Ricardo J. Miragaia, Guy Naamati, Gosia Trynka, Mike Dennis, Valentina Proserpio, Jong-Eun Park, Peter Vegh, Giacomo Donati, Tzachi Hagai, Johan Henriksson, Muzlifah Haniffa, Lara Bossini-Castillo, Emily Stephenson, Natalia Kunowska, Armita Nourmohammad
Publikováno v:
Nature
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
As the first line of defence against pathogens, cells mount an innate immune response, which varies widely from cell to cell. The response must be potent but carefully controlled to avoid self-damage. How these constraints have shaped the evolution o