Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ricardo D, Fernández"'
Autor:
Heather R Lucas, Ricardo D Fernández
Publikováno v:
Neural Regeneration Research, Vol 15, Iss 3, Pp 407-415 (2020)
N-acetylated α-synuclein (αSyn) has long been established as an intrinsically disordered protein associated with a dysfunctional role in Parkinson’s disease. In recent years, a physiologically relevant, higher order conformation has been identifi
Externí odkaz:
https://doaj.org/article/30f4b859056d449db4759841f1ef3dea
Autor:
Ricardo D. Fernández, Heather R. Lucas
Publikováno v:
Data in Brief, Vol 20, Iss , Pp 1686-1691 (2018)
Tetrameric α-synuclein (αS) is an elusive multimer of the dynamic neuronal protein implicated in Parkinson׳s disease. Through the data reported herein, we demonstrate that this high molecular weight multimer is N-acetylated. Coexpression of tetram
Externí odkaz:
https://doaj.org/article/c8fa642a61704269a45ebed28c4780e3
Autor:
Dinendra L Abeyawardhane, Morgan L Trahan, Heather R. Lucas, Ricardo D. Fernández, Talita D Pagani, Alyson M. Curry
Publikováno v:
Life, Vol 10, Iss 124, p 124 (2020)
Life
Volume 10
Issue 8
Life
Volume 10
Issue 8
Parkinson&rsquo
s disease (PD) is the second most common neurological disease and belongs to a group of neurodegenerative disorders called synucleinopathies in which pathological aggregates of N-terminally acetylated &alpha
synuclein (NAc&a
s disease (PD) is the second most common neurological disease and belongs to a group of neurodegenerative disorders called synucleinopathies in which pathological aggregates of N-terminally acetylated &alpha
synuclein (NAc&a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514243a9d844cdd6fd74f636e129e810
https://www.mdpi.com/2075-1729/10/8/124
https://www.mdpi.com/2075-1729/10/8/124
Autor:
Heather R. Lucas, Madeleine K Crozier, Dinendra L Abeyawardhane, Ricardo D. Fernández, Denver R. Heitger, Julia C Wolver
Publikováno v:
Journal of the American Chemical Society. 140:17086-17094
Aggregation of the neuronal protein α-synuclein (αS) is a critical factor in the pathogenesis of Parkinson’s disease. Analytical methods to detect post-translational modifications of αS are under development, yet the mechanistic underpinnings of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d137f3a953a1799ec6b394f9a25301cf
https://doi.org/10.1021/jacs.8b08947
https://doi.org/10.1021/jacs.8b08947
Autor:
Ashley K. Forney, Dinendra L Abeyawardhane, Ricardo D. Fernández, Heather R. Lucas, Denver R. Heitger
Publikováno v:
ACS Chemical Neuroscience. 10:1402-1410
The structurally dynamic amyloidogenic protein α-synuclein (αS) is universally recognized as a key player in Parkinson’s disease (PD). Copper, which acts as a neuronal signaling agent, is also an effector of αS structure, aggregation, and locali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89a969b63b8e0d54b5997411949b6e7e
https://doi.org/10.1021/acschemneuro.8b00448
https://doi.org/10.1021/acschemneuro.8b00448
Autor:
Ricardo D. Fernández, Heather R. Lucas
Publikováno v:
Neural Regeneration Research
Neural Regeneration Research, Vol 15, Iss 3, Pp 407-415 (2020)
Neural Regeneration Research, Vol 15, Iss 3, Pp 407-415 (2020)
N-acetylated α-synuclein (αSyn) has long been established as an intrinsically disordered protein associated with a dysfunctional role in Parkinson’s disease. In recent years, a physiologically relevant, higher order conformation has been identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a88ce0ae241505b292c828f1458eb402
https://doi.org/10.4103/1673-5374.265792
https://doi.org/10.4103/1673-5374.265792
Autor:
Dinendra L, Abeyawardhane, Denver R, Heitger, Ricardo D, Fernández, Ashley K, Forney, Heather R, Lucas
Publikováno v:
ACS chemical neuroscience. 10(3)
The structurally dynamic amyloidogenic protein α-synuclein (αS) is universally recognized as a key player in Parkinson's disease (PD). Copper, which acts as a neuronal signaling agent, is also an effector of αS structure, aggregation, and localiza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ff33e3c5c7d8f9d45ec6c0bf38ee3f9
https://pubmed.ncbi.nlm.nih.gov/30384594
https://pubmed.ncbi.nlm.nih.gov/30384594
Autor:
Denver R. Heitger, Dinendra L Abeyawardhane, Heather R. Lucas, Ricardo D. Fernández, Madeleine K Crozier, Cody J. Murgas, Ashley K. Forney
Publikováno v:
Journal of the American Chemical Society. 140(15)
Brain metal dyshomeostasis and altered structural dynamics of the presynaptic protein α-synuclein (αS) are both implicated in the pathology of Parkinson’s disease (PD), yet a mechanistic understanding of disease progression in the context of αS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e440bab7a463c499f72a598ba023a46c
https://pubmed.ncbi.nlm.nih.gov/29608844
https://pubmed.ncbi.nlm.nih.gov/29608844
Autor:
Heather R. Lucas, Ricardo D. Fernández
Publikováno v:
Protein expression and purification. 152
Parkinson's disease (PD) is multifactorial, likely resulting from an intricate relationship of genetic and environmental factors affecting fundamental cellular processes. Histopathological hallmarks of PD include the development of granular inclusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9810b4115d332389bbc44736157e3476
https://pubmed.ncbi.nlm.nih.gov/30041032
https://pubmed.ncbi.nlm.nih.gov/30041032
Autor:
Ashley K. Forney, Cody J. Murgas, Denver R. Heitger, Dinendra L Abeyawardhane, Heather R. Lucas, Ricardo D. Fernández, Alyson M. Curry
Publikováno v:
Biophysical Journal. 116:496a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a79abfc6f180ef1ad547b327aea8642
https://doi.org/10.1016/j.bpj.2018.11.2676
https://doi.org/10.1016/j.bpj.2018.11.2676