Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ricardo Cruz-Acuña"'
Autor:
Mohammad Faujul Kabir, Adam L. Karami, Ricardo Cruz-Acuña, Alena Klochkova, Reshu Saxena, Anbin Mu, Mary Grace Murray, Jasmine Cruz, Annie D. Fuller, Margarette H. Clevenger, Kumaraswamy Naidu Chitrala, Yinfei Tan, Kelsey Keith, Jozef Madzo, Hugh Huang, Jaroslav Jelinek, Tatiana Karakasheva, Kathryn E. Hamilton, Amanda B. Muir, Marie-Pier Tétreault, Kelly A. Whelan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The level of cellular diversity in the esophageal epithelium has yet to be classified at the single cell level. Here the authors analyze the transcriptome of 44,679 murine esophageal keratinocytes to identify an unexpected level of cellular heterogen
Externí odkaz:
https://doaj.org/article/08d60dfa06354f1792c694cb232b3b9d
Autor:
Ya-Wen Chang, Ricardo Cruz-Acuña, Michael Tennenbaum, Alexandros A. Fragkopoulos, Andrés J. García, Alberto Fernández-Nieves
Publikováno v:
Frontiers in Physics, Vol 10 (2022)
Out-of-plane curvature is an important, but poorly explored geometric parameter that influences cell behavior. We address the impact of curvature on epithelial proliferation through monitoring how MDCK cells proliferate on planar and curved toroidal
Externí odkaz:
https://doaj.org/article/c91b476c01874fd8bc920450aa8b4bdd
Autor:
Tatiana A. Karakasheva, Joel T. Gabre, Uma M. Sachdeva, Ricardo Cruz-Acuña, Eric W. Lin, Maureen DeMarshall, Gary W. Falk, Gregory G. Ginsberg, Zhaohai Yang, Michele M. Kim, Eric S. Diffenderfer, Jason R. Pitarresi, Jinyang Li, Amanda B. Muir, Kathryn E. Hamilton, Hiroshi Nakagawa, Adam J. Bass, Anil K. Rustgi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract 3D patient-derived organoids (PDOs) have been utilized to evaluate potential therapies for patients with different cancers. However, the use of PDOs created from treatment-naive patient biopsies for prediction of clinical outcomes in patient
Externí odkaz:
https://doaj.org/article/43bca536a467471b9f4d262b3322f68e
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102475- (2021)
Summary: Recent engineering technologies have transformed traditional perspectives of cancer to include the important role of the extracellular matrix (ECM) in recapitulating the malignant behaviors of cancer cells. Novel biomaterials and imaging tec
Externí odkaz:
https://doaj.org/article/6d140da6052a473d85f03daa04a26565
Autor:
Ricardo Cruz-Acuña, Secunda W. Kariuki, Kensuke Sugiura, Claudia Loebel, Tatiana Karakasheva, Joel T. Gabre, Jason A. Burdick, Anil K. Rustgi
Increased extracellular matrix (ECM) stiffness has been implicated in esophageal adenocarcinoma (EAC) progression, metastasis, and resistance to therapy. However, the underlying pro-tumorigenic pathways are yet to be defined. Additional work is neede
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5fa1f22b7acb199e326bfc37260f0a2
https://doi.org/10.1101/2022.11.13.516357
https://doi.org/10.1101/2022.11.13.516357
Autor:
Joshua S.T. Hooks, Fabrice C. Bernard, Ricardo Cruz-Acuña, Zhanna Nepiyushchikh, Yarelis Gonzalez-Vargas, Andrés J. García, J. Brandon Dixon
Publikováno v:
Biomaterials
The lymphatic vasculature is an essential component of the body's circulation providing a network of vessels to return fluid and proteins from the tissue space to the blood, to facilitate immune ce-ll and antigen transport to lymph nodes, and to take
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f248e7eb5264344cbdd4b203d79f4e45
https://europepmc.org/articles/PMC9134840/
https://europepmc.org/articles/PMC9134840/
Autor:
Ricardo Cruz-Acuña, Secunda W. Kariuki, Claudia Loebel, Tatiana Karakasheva, Joel T. Gabre, Jason A. Burdick, Anil K. Rustgi
Publikováno v:
Cancer Research. 82:3838-3838
INTRODUCTION: Changes in the tumor microenvironment arbitrated by a stiffened ECM are associated with tumor aggression and enable increased propensity towards metastasis. For instance, in vitro (2D) studies have implicated ECM properties in EAC progr
Autor:
Mohammad Faujul Kabir, Adam L. Karami, Ricardo Cruz-Acuña, Alena Klochkova, Reshu Saxena, Anbin Mu, Mary Grace Murray, Jasmine Cruz, Annie D. Fuller, Margarette H. Clevenger, Kumaraswamy Naidu Chitrala, Yinfei Tan, Kelsey Keith, Jozef Madzo, Hugh Huang, Jaroslav Jelinek, Tatiana Karakasheva, Kathryn E. Hamilton, Amanda B. Muir, Marie-Pier Tétreault, Kelly A. Whelan
Publikováno v:
Nature communications. 13(1)
Although morphologic progression coupled with expression of specific molecular markers has been characterized along the esophageal squamous differentiation gradient, the molecular heterogeneity within cell types along this trajectory has yet to be cl
Autor:
Andrés J. García, Ricardo Cruz-Acuña
Publikováno v:
Experimental Cell Research. 377:109-114
Human organoids provide constructive in vitro models of human development and disease, as these recapitulate important morphogenetic and functional features of the tissue and species of origin. However, organoid culture technologies often involve the
Autor:
Ricardo Cruz-Acuña, Hiroshi Nakagawa, Samuel Flashner, Uma M. Sachdeva, Masataka Shimonosono, Joel Gabre
Publikováno v:
Cancer Lett
Three-dimensional (3D) organoids are a novel tool to model epithelial cell biology and human diseases of the esophagus. 3D organoid culture systems have been utilized to investigate the pathobiology of esophageal cancer, including both squamous cell