Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling

Autor: Hong Chang, Qing Li, Michael T. Lewis, Ricardo C. Moraes, Paul A. Hamel

Publikováno v: The International Journal of Biochemistry & Cell Biology. 42:1462-1471

Hedgehog (Hh) signalling is mediated through the Patched-1 (Ptch1) receptor. Hh-binding to Ptch1 blocks the inhibitory effects of Ptch1 on the activity of the transmembrane protein, Smoothened (Smo), resulting induction of target genes by the Gli-fam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4fbb5cf31b011d4b2c74fb39133810b
https://doi.org/10.1016/j.biocel.2010.04.016

Cyclopamine inhibition of human breast cancer cell growth independent of Smoothened (Smo)

Autor: Xiaomei Zhang, Ricardo C. Moraes, Meng-Fen Wu, Susan G. Hilsenbeck, Michael T. Lewis, Nikesha Harrington

Publikováno v: Breast Cancer Research and Treatment. 115:505-521

Altered hedgehog signaling is implicated in the development of approximately 20-25% of all cancers, especially those of soft tissues. Genetic evidence in mice as well as immunolocalization studies in human breast cancer specimens suggest that deregul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5051baf5ecfb5a59dc3bd4b15c6e363e
https://doi.org/10.1007/s10549-008-0093-3

Microarray Analysis of Alterations Induced by Obesity in White Adipose Tissue Gene Expression Profiling

Autor: J. Tirard, Danielle Naville, Ricardo C. Moraes, M. Begeot

Publikováno v: Contemporary Endocrinology ISBN: 9781588296511

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d20dd4f451429bff8df15b0e07c32b28
https://doi.org/10.1007/978-1-59745-309-7_13

Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models

Autor: Ricardo C. Moraes, Ekaterina Bogoslovskaia, Yi Li, Xiaomei Zhang, Michele M. Fluck, Zhijun Du, Shixia Huang, D. Craig Allred, Michael J. Toneff, Amanda McGrath, Harold E. Varmus, Katrina Podsypanina, Michael T. Lewis

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 103(46)

We have adapted the avian leukosis virus RCAS (replication-competent avian sarcoma-leukosis virus LTR splice acceptor)-mediated somatic gene transfer technique to introduce oncogenes into mammary cells in mice transgenic for the avian subgroup A rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b610c7b38f5236dfada018e8b1213b5e
https://pubmed.ncbi.nlm.nih.gov/17090666

Study of the alteration of gene expression in adipose tissue of diet-induced obese mice by microarray and reverse transcription-polymerase chain reaction analyses

Autor: A Blondet, Torben F. Ørntoft, K Birkenkamp-Demtroeder, J. Tirard, Ricardo C. Moraes, Danielle Naville, Philippe Durand, Martine Begeot, Arieh Gertler

Publikováno v: Endocrinology
Endocrinology, Endocrine Society, 2003, 144 (11), pp.4773-4782
Moraes, R C, Blondet, A, Birkenkamp-Demtröder, K, Tirard, J, Ørntoft, T F, Gertler, A, Durand, P, Naville, D & Begeot, M 2003, ' Study of the alteration of gene expression in adipose tissue of diet-induce obese mice by microarray and reverse transcription-polymerase chain reaction analyses ', Endocinology, vol. 144, no. 11, pp. 4773-4782 .
Aarhus University

In the present study we developed a model of diet-induced obesity (DIO) in male C57 BL/6J mice using an 8-wk high fat diet. This model should better reflect the physiology of the majority of the human obese patients than mouse genetic models of obesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2822f1d9094eb618c27104cf54085fe6
https://hal.inrae.fr/hal-02674163