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pro vyhledávání: '"Ricardo A. P. Pádua"'
Autor:
Ricardo A. P. Pádua, Yizhi Sun, Ingrid Marko, Warintra Pitsawong, John B. Stiller, Renee Otten, Dorothee Kern
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The protein tyrosine phosphatase SHP2 is a key regulator of cell cycle control. Here the authors combine NMR measurements and X-ray crystallography and show that wild-type SHP2 dynamically exchanges between a closed inactive conformation and an open
Externí odkaz:
https://doaj.org/article/77cc04b8724e47ce9663728a803fea11
Akademický článek
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Autor:
Warintra Pitsawong, Ricardo A. P. Pádua, Timothy Grant, Marc Hoemberger, Renee Otten, Niels Bradshaw, Nikolaus Grigorieff, Dorothee Kern
Circadian rhythms play an essential part in many biological processes, and only three prokaryotic proteins are required to constitute a true post-translational circadian oscillator1. The evolutionary history of the three Kai proteins indicates that K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3f3c0c256660180a41792253a159b4
https://doi.org/10.1101/2022.11.28.518275
https://doi.org/10.1101/2022.11.28.518275
Autor:
Warintra Pitsawong, Vanessa Buosi, Renee Otten, Roman V. Agafonov, Adelajda Zorba, Nadja Kern, Steffen Kutter, Gunther Kern, Ricardo A. P. Pádua, Xavier Meniche, Dorothee Kern
Protein kinases are major drug targets, but the development of highly-selective inhibitors has been challenging due to the similarity of their active sites. The observation of distinct structural states of the fully-conserved Asp-Phe-Gly (DFG) loop h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b0872372260ae60e8eea19c9a44fc4