Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ricardo A. M. Serafim"'
Publikováno v:
Pharmaceuticals, Vol 17, Iss 2, p 206 (2024)
Covalent inhibitors have experienced a revival in medicinal chemistry and chemical biology in recent decades [...]
Externí odkaz:
https://doaj.org/article/7140dcbb3d064635b972e1b4426865cd
Autor:
Ricardo A. M. Serafim, André da Silva Santiago, Martin P. Schwalm, Zexi Hu, Caio V. dos Reis, Jessica E. Takarada, Priscila Mezzomo, Katlin B. Massirer, Mark Kudolo, Stefan Gerstenecker, Apirat Chaikuad, Lars Zender, Stefan Knapp, Stefan Laufer, Rafael M. Couñago, Matthias Gehringer
Publikováno v:
Journal of Medicinal Chemistry. 65:3173-3192
Monopolar spindle kinase 1 (MPS1/TTK) is a key element of the mitotic checkpoint and clinically evaluated as a target in the treatment of aggressive tumors such as triple-negative breast cancer. While long drug-target residence times have been sugges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f487f2c8d895ec56739c4e762882757
https://doi.org/10.1021/acs.jmedchem.1c01165
https://doi.org/10.1021/acs.jmedchem.1c01165
Autor:
Stanley Nunes Siqueira Vasconcelos, Katlin B. Massirer, Ricardo A. M. Serafim, Hitesh Patel, Jim Bennett, Oleg Fedorov, Stefan Knapp, Benedict-Tilman Berger, William J. Zuercher, Ross J. Collins, Jonathan M. Elkins, F.J. Sorrell
Publikováno v:
Journal of Medicinal Chemistry. 64:13259-13278
SLK (STE20-like kinase) and STK10 (serine/threonine kinase 10) are closely related kinases whose enzymatic activity is linked to the regulation of ezrin, radixin, and moesin function and to the regulation of lymphocyte migration and the cell cycle. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa29241ce6a03c4de90d4ac1d4c2817a
https://doi.org/10.1021/acs.jmedchem.0c01579
https://doi.org/10.1021/acs.jmedchem.0c01579
Autor:
William J. Zuercher, Ricardo A. M. Serafim, Matthias Gehringer, Stefan Laufer, Jonathan M. Elkins
Over 20 years after the approval of the first-in-class protein kinase inhibitor imatinib, the biological function of a significant fraction of the human kinome remains poorly understood while most research continues to be focused on few well-validate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ab403dd02af1eb4abc17c177240bd9
https://doi.org/10.1021/acs.jmedchem.1c00980
https://doi.org/10.1021/acs.jmedchem.1c00980
Autor:
Stefan Laufer, Mark Kudolo, Ricardo A. M. Serafim, Martin Schröder, Apirat Chaikuad, Valentin Wydra, Stefan Gerstenecker, Stefan Knapp, Martin P. Schwalm, Lisa Haarer, Matthias Gehringer
Publikováno v:
Cancers, Vol 13, Iss 5133, p 5133 (2021)
Cancers
Volume 13
Issue 20
Cancers
Volume 13
Issue 20
Simple Summary The two human p70 ribosomal S6 kinases, S6K1 and S6K2, have been associated with a variety of cellular processes and human pathologies, especially cancer. Thus far, only S6K1 was thoroughly studied and selectively addressed by small mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507eb9e9129a0d0c4760d1a96230fa96
https://www.mdpi.com/2072-6694/13/20/5133
https://www.mdpi.com/2072-6694/13/20/5133
Autor:
Katlin B. Massirer, Priscila Mezzomo, Mark Kudolo, A.S. Santiago, Apirat Chaikuad, Caio V. dos Reis, Matthias Gehringer, Rafael M. Couñago, Jessica Takarada, Ricardo A. M. Serafim, Stefan Knapp, Martin P. Schwalm, Stefan Laufer, Stefan Gerstenecker
Monopolar spindle kinase 1 (MPS1/TTK) is a key element of the mitotic checkpoint securing proper chromosome segregation. It is being evaluated as a target in the treatment of aggressive tumors such as triple-negative breast cancer with several revers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b037609509dc018037dcddecb4ee07df
https://doi.org/10.26434/chemrxiv.14601264
https://doi.org/10.26434/chemrxiv.14601264
Autor:
Ricardo A. M. Serafim, Matthias Gehringer, Stanislav Andreev, Teodor Dimitrov, Stefan Gerstenecker, Valentin Wydra, Dieter Schollmeyer, Stefan Laufer
Publikováno v:
Molbank, Vol 2021, Iss M1181, p M1181 (2021)
Here we describe the synthesis of N-(6-chloro-3-nitropyridin-2-yl)5-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-amine via a three-step procedure including a Buchwald–Hartwig arylamination with benzophenone imine and a highly regioselective nucleophilic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd9e42da8b481d208bc1647b157d315
https://www.mdpi.com/1422-8599/2021/1/M1181
https://www.mdpi.com/1422-8599/2021/1/M1181
Autor:
Jessica Takarada, Fulvia Di Pillo, Jonathan M. Elkins, A.S. Santiago, Ricardo A. M. Serafim, Fernando H. de Souza Gama, Hatylas Azevedo, Luiz A Dutra, C.R.W. Guimaraes, Opher Gileadi, A. Mascarello, Stanley Nunes Siqueira Vasconcelos, Caio V. dos Reis, Katlin B. Massirer, Rafael M. Couñago
Publikováno v:
ACS Medicinal Chemistry Letters
Vaccinia-related kinases 1 and 2 (VRK1 and VRK2) are human Ser/Thr protein kinases associated with increased cell division and neurological disorders. Nevertheless, the cellular functions of these proteins are not fully understood. Despite their ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ab0cf47b6cdbbc2a11351987287a49
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid: