Zobrazeno 1 - 10
of 873
pro vyhledávání: '"Ricardo A. Gomes"'
Autor:
Inês C. Ferreira, Estefania Torrejón, Bernardo Abecasis, Bruno M. Alexandre, Ricardo A. Gomes, Chris Verslype, Jos van Pelt, Ana Barbas, Daniel Simão, Tiago M. Bandeiras, Alessio Bortoluzzi, Sofia P. Rebelo
Publikováno v:
SLAS Discovery, Vol 29, Iss 3, Pp 100154- (2024)
Sorafenib is a multikinase inhibitor indicated for first-line treatment of unresectable hepatocellular carcinoma. Despite its widespread use in the clinic, the existing knowledge of sorafenib mode-of-action remains incomplete. To build upon the curre
Externí odkaz:
https://doaj.org/article/f74d704ab68c4276ae4077cfc067a125
Autor:
Ana Chegão, Mariana Guarda, Bruno M. Alexandre, Liana Shvachiy, Mariana Temido-Ferreira, Inês Marques-Morgado, Bárbara Fernandes Gomes, Rune Matthiesen, Luísa V. Lopes, Pedro R. Florindo, Ricardo A. Gomes, Patrícia Gomes-Alves, Joana E. Coelho, Tiago Fleming Outeiro, Hugo Vicente Miranda
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-22 (2022)
Abstract Alpha-synuclein (aSyn) is a central player in the pathogenesis of synucleinopathies due to its accumulation in typical protein aggregates in the brain. However, it is still unclear how it contributes to neurodegeneration. Type-2 diabetes mel
Externí odkaz:
https://doaj.org/article/505e44be1dd441bfb7ad630258f5cddb
Autor:
Guillaume L. Erny, Ricardo A. Gomes, Mónica S. F. Santos, Lúcia Santos, Nuno Neuparth, Pedro Carreiro-Martins, João Gaspar Marques, Ana C. L. Guerreiro, Patrícia Gomes-Alves
Publikováno v:
ACS Omega, Vol 5, Iss 26, Pp 16089-16098 (2020)
Externí odkaz:
https://doaj.org/article/050d70da49434e2b8d6f2a0a57fac7d3
Autor:
Bárbara Fernandes, Rute Castro, Farien Bhoelan, Denzel Bemelman, Ricardo A. Gomes, Júlia Costa, Patrícia Gomes-Alves, Toon Stegmann, Mario Amacker, Paula M. Alves, Sylvain Fleury, António Roldão
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 854 (2022)
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) homotrimeric spike (S) protein is responsible for mediating host cell entry by binding to the angiotensin-converting enzyme 2 (ACE2) receptor, thus being a key viral antigen to target i
Externí odkaz:
https://doaj.org/article/37374a4e5b5e4165b6175b7d3f93c726
Autor:
Júlia Costa, Marta Gromicho, Ana Pronto-Laborinho, Conceição Almeida, Ricardo A. Gomes, Ana C. L. Guerreiro, Abel Oliva, Susana Pinto, Mamede de Carvalho
Publikováno v:
Diagnostics, Vol 11, Iss 7, p 1210 (2021)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative neuromuscular disease that affects motor neurons controlling voluntary muscles. Survival is usually 2–5 years after onset, and death occurs due to respiratory failure. The identification of
Externí odkaz:
https://doaj.org/article/ef931e44707d41d6ad26666a0ae421a3
Publikováno v:
Journal of High Energy Physics, Vol 2017, Iss 11, Pp 1-29 (2017)
Abstract We investigate the present constraints from MINOS and T2K experiments for the neutrino decay scenario induced by non-diagonal couplings of Majorons to neutrinos. As novelty, on top of the typical invisible decay prescription, we add the cont
Externí odkaz:
https://doaj.org/article/a6b813120e774bbb9e9af2bd204b4c8a
Publikováno v:
Revista Brasileira de Parasitologia Veterinária, Vol 17, Iss 2, Pp 73-80 (2008)
O objetivo do presente estudo foi analisar a resposta imune humoral anti-Anaplasma marginale em búfalos (Bubalus bubalis) naturalmente infectados. Amostras de soro e de colostro/leite coletadas de búfalas adultas por um período de 335 dias após o
Externí odkaz:
https://doaj.org/article/fdd316724179463090b1b71ac06fc870
Autor:
Natalia Sanchez de Groot, Ricardo A. Gomes, Anna Villar-Pique, M. Madan Babu, Ana Varela Coelho, Salvador Ventura
Publikováno v:
Open Biology, Vol 5, Iss 2 (2015)
Proteins adopt defined structures and are crucial to most cellular functions. Their misfolding and aggregation is associated with numerous degenerative human disorders such as type II diabetes, Huntington's or Alzheimer's diseases. Here, we aim to un
Externí odkaz:
https://doaj.org/article/8ebcc5705e254bab9252f13dde34a7aa
Autor:
de Favare, Giordani Mascoli, de Almeida Cipriano, Isabela, do Carmo, Tábata Alves, Mena, Mateus Oliveira, Guelpa, Gabriel Jabismar, do Amarante, Alessandro Francisco Talamini, de Soutello, Ricardo Velludo Gomes
Publikováno v:
In Veterinary Parasitology: Regional Studies and Reports June 2023 41
