Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Ricardo, de Pascual"'
Publikováno v:
Biology, Vol 11, Iss 4, p 511 (2022)
Alzheimer’s disease (AD), the most common form of dementia, is becoming a global health problem and public health priority. In the advanced stages of AD, besides the initial cognitive symptoms, behavioral problems, particularly agitation and aggres
Externí odkaz:
https://doaj.org/article/062bf90818da4c53ab8e0eca9d210ab3
Autor:
Ricardo de Pascual, Francesco Calzaferri, Paula C. Gonzalo, Rubén Serrano-Nieto, Cristóbal de los Ríos, Antonio G. García, Luis Gandía
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 440 (2021)
Upon depolarization of chromaffin cells (CCs), a prompt release of catecholamines occurs. This event is triggered by a subplasmalemmal high-Ca2+ microdomain (HCMD) generated by Ca2+ entry through nearby voltage-activated calcium channels. HCMD is eff
Externí odkaz:
https://doaj.org/article/d5b1cbf421af43f391b2c02959205d98
Autor:
Marina Arribas-Blázquez, Luis Alcides Olivos-Oré, María Victoria Barahona, Aneta Wojnicz, Ricardo De Pascual, Mercedes Sánchez de la Muela, Antonio G. García, Antonio R. Artalejo
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 8325 (2020)
We have investigated whether the stress response mediated by the adrenal medulla in rats subjected to chronic constriction injury of the sciatic nerve (CCI) modulates their nocifensive behavior. Treatment with SK29661 (300 mg/kg; intraperitoneal (I.P
Externí odkaz:
https://doaj.org/article/1207c9eacf48426cb311fe3ffcc12c20
Autor:
Andrés M. Baraibar, Ricardo de Pascual, Victoria Jiménez Carretero, Ninfa Liccardi, Natalia Hernández Juárez, Jesús M. Hernández‐Guijo
Aluminium (Al3+) has long been related to neurotoxicity and neurological diseases. This study aims to describe the specific actions of this metal on cellular excitability and neurotransmitter release. Al3+reduced intracellular calcium concentrations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ece75b9405232546e6493b36c4235907
https://doi.org/10.1101/2023.01.25.525351
https://doi.org/10.1101/2023.01.25.525351
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2565
Amperometry is an electrochemical method based on the oxidation or reduction of molecules. Many secretion products, including catecholamines, contain in their molecule chemical groups with the ability to yield (oxidize) or capture (reduce) electrons
Autor:
Rafaela Teixeira, Cristóbal de los Ríos, Luis Gandía, Katia G. Lima-Araújo, Monique Araújo de Brito, Claudia Lucia Martins Silva, Ricardo de Pascual, Artur F. do Carmo, Wilson C. Santos, Thelma de Barros Machado
Publikováno v:
Natural Product Research. 35:4870-4875
We investigated the role of triterpene barbinervic acid from Eugenia punicifolia dichloromethane extract in vasopressor responses. Renal arteries were cannulated and perfused with Krebs-Hepes solut...
Publikováno v:
Clínica y Salud. Investigación Empírica en Psicología, Vol 23, Iss 2, Pp 181-195 (2012)
En el presente artículo se presenta un análisis funcional de la conducta verbal del terapeuta en un caso típico de ansiedad. Una vez catalogadas las verbalizaciones terapéuticas a reforzar y las antiterapéuticas a extinguir, se analiza hasta qu
Externí odkaz:
https://doaj.org/article/c2e3e8a890a746d480f045c730eeb86c
Autor:
Cristina Ruiz-Ruiz, Antonio G. García, Giulia Govoni, Alicia Muñoz-Montero, Antonio M. G. de Diego, Ricardo de Pascual, Luis Gandía, Fernanda García-Alvarado
Publikováno v:
NeuroToxicology. 70:99-111
In the frame of a repositioning programme with cholinergic medicines in clinical use searching for neuroprotective properties, we surprisingly found that spasmolytic antimuscarinics otilonium and pinaverium exhibited neurotoxic effects in neuronal cu
Autor:
Annette Nicke, Antonio M. G. de Diego, Ricardo de Pascual, Paloma Narros-Fernández, Javier Egea, Antonio G. García, Cristóbal de los Ríos, Francesco Calzaferri
Publikováno v:
Journal of Medicinal Chemistry
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
The ATP-gated P2X7 purinergic receptor (P2X7) is involved in the pathogenesis of many neurodegenerative diseases (NDDs). Several P2X7 antagonists have been developed, though none of them reached clinical trials for this indication. In this work, we d
Autor:
Luis Gandía, Victoria Maneu, Antonio G. García, Ricardo de Pascual, María F. Cano-Abad, Iago Méndez-López, Cristina Ruiz-Ruiz, Cristóbal de los Ríos, Francesco Calzaferri, Antonio M. G. de Diego
Publikováno v:
Medicinal Research Reviews
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
RUA. Repositorio Institucional de la Universidad de Alicante
Universidad de Alicante (UA)
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
RUA. Repositorio Institucional de la Universidad de Alicante
Universidad de Alicante (UA)
Neurodegenerative diseases (NDDs) represent a huge social burden, particularly in Alzheimer's disease (AD) in which all proposed treatments investigated in murine models have failed during clinical trials (CTs). Thus, novel therapeutic strategies rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fe973abf104824aeb1864debb2d839
https://hdl.handle.net/10486/697548
https://hdl.handle.net/10486/697548