Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias

Autor: Ricardo de Matos Simoes, Ryosuke Shirasaki, Sondra L. Downey-Kopyscinski, Geoffrey M. Matthews, Benjamin G. Barwick, Vikas A. Gupta, Daphné Dupéré-Richer, Shizuka Yamano, Yiguo Hu, Michal Sheffer, Eugen Dhimolea, Olga Dashevsky, Sara Gandolfi, Kazuya Ishiguro, Robin M. Meyers, Jordan G. Bryan, Neekesh V. Dharia, Paul J. Hengeveld, Johanna B. Brüggenthies, Huihui Tang, Andrew J. Aguirre, Quinlan L. Sievers, Benjamin L. Ebert, Brian J. Glassner, Christopher J. Ott, James E. Bradner, Nicholas P. Kwiatkowski, Daniel Auclair, Joan Levy, Jonathan J. Keats, Richard W. J. Groen, Nathanael S. Gray, Aedin C. Culhane, James M. McFarland, Joshua M. Dempster, Jonathan D. Licht, Lawrence H. Boise, William C. Hahn, Francisca Vazquez, Aviad Tsherniak, Constantine S. Mitsiades

Publikováno v: de Matos Simoes, R, Shirasaki, R, Downey-Kopyscinski, S L, Matthews, G M, Barwick, B G, Gupta, V A, Dupéré-Richer, D, Yamano, S, Hu, Y, Sheffer, M, Dhimolea, E, Dashevsky, O, Gandolfi, S, Ishiguro, K, Meyers, R M, Bryan, J G, Dharia, N V, Hengeveld, P J, Brüggenthies, J B, Tang, H, Aguirre, A J, Sievers, Q L, Ebert, B L, Glassner, B J, Ott, C J, Bradner, J E, Kwiatkowski, N P, Auclair, D, Levy, J, Keats, J J, Groen, R W J, Gray, N S, Culhane, A C, McFarland, J M, Dempster, J M, Licht, J D, Boise, L H, Hahn, W C, Vazquez, F, Tsherniak, A & Mitsiades, C S 2023, ' Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias ', Nature Cancer, vol. 4, no. 5, pp. 754-773 . https://doi.org/10.1038/s43018-023-00550-x
Nature Cancer, 4(5), 754-773. Nature Research

Clinical progress in multiple myeloma (MM), an incurable plasma cell (PC) neoplasia, has been driven by therapies that have limited applications beyond MM/PC neoplasias and do not target specific oncogenic mutations in MM. Instead, these agents targe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c38520e5128234e34753590416d0e64
https://doi.org/10.1038/s43018-023-00550-x

Data from Pleiotropic Mechanisms Drive Endocrine Resistance in the Three-Dimensional Bone Microenvironment

Autor: Constantine S. Mitsiades, Irene Georgakoudi, Myles Brown, Aedín C. Culhane, Rinath Jeselsohn, Yu Chen, Joseph H. Schwab, Nicholas Mitsiades, Dong Gao, Zhiyi Liu, Pallavi Awate, Shruti Sharma, Xiang Weng, Dhvanir Kansara, Ricardo de Matos Simoes, Eugen Dhimolea

Although hormonal therapy (HT) inhibits the growth of hormone receptor–positive (HR+) breast and prostate cancers, HT resistance frequently develops within the complex metastatic microenvironment of the host organ (often the bone), a setting poorly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb0100e3894c340d1a10b497f582e965
https://doi.org/10.1158/0008-5472.c.6512674.v1

Single-cell functional genomics of natural killer cell evasion in blood cancers

Autor: Olli Dufva, Sara Gandolfi, Jani Huuhtanen, Olga Dashevsky, Khalid Saeed, Jay Klievink, Petra Nygren, Jonas Bouhlal, Jenni Lahtela, Anna Näätänen, Bishwa R Ghimire, Tiina Hannunen, Pekka Ellonen, Hanna Duàn, Jason Theodoropoulos, Essi Laajala, Jouni Härkönen, Petri Pölönen, Merja Heinäniemi, Shizuka Yamano, Ryosuke Shirasaki, David Barbie, Jennifer Roth, Rizwan Romee, Michal Sheffer, Harri Lähdesmäki, Dean A. Lee, Ricardo De Matos Simoes, Matti Kankainen, Constantine S Mitsiades, Satu Mustjoki

SUMMARYNatural killer (NK) cells are emerging as a promising therapeutic option in cancer. To better understand how cancer cells evade NK cells, we studied interacting NK and blood cancer cells using single-cell and genome-scale functional genomics s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6e27224ae13be7a91b163142aaeb31e
https://doi.org/10.1101/2022.08.22.504722

Systematic Functional Characterization for Loss of Function Events Cooperating with TP53 Loss in High-Risk 17p13(del) Multiple Myeloma

Autor: Phaik Ju Teoh, Ricardo De Matos Simoes, Tae-Hoon Chung, Mick Lee, Olga Dashevsky, Shizuka Yamano, Roger Foo, Wee Joo Chng, Constantine S. Mitsiades

Publikováno v: Blood. 140:7110-7111

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fedd95be324647891da9c4a15942107
https://doi.org/10.1182/blood-2022-159316

TSPAN6 is a suppressor of Ras-driven cancer

Autor: Patrick O. Humbert, Tamara Zoranovic Pryjda, Blanka Pranjic, Andrew Farrell, Kohei Fujikura, Ricardo de Matos Simoes, Rezaul Karim, Ivona Kozieradzki, Shane J. F. Cronin, G. Gregory Neely, Thomas F. Meyer, Astrid Hagelkruys, Helena E. Richardson, Josef M. Penninger

Publikováno v: Oncogene

Oncogenic mutations in the small GTPase RAS contribute to ~30% of human cancers. In a Drosophila genetic screen, we identified novel and evolutionary conserved cancer genes that affect Ras-driven tumorigenesis and metastasis in Drosophila including c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2420af14cea2d0eef2273bd0634ea516
https://hdl.handle.net/21.11116/0000-000A-2C85-F21.11116/0000-000A-0B0F-B