Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ricarda Sabitzki"'
Autor:
Hannah M. Behrens, Sabine Schmidt, Isabelle G. Henshall, Patricia López-Barona, Domitille Peigney, Ricarda Sabitzki, Jürgen May, Oumou Maïga-Ascofaré, Tobias Spielmann
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT Reduced susceptibility to ART, the first-line treatment against malaria, is common in South East Asia (SEA). It is associated with point mutations, mostly in kelch13 (k13) but also in other genes, like ubp1. K13 and its compartment neighbors
Externí odkaz:
https://doaj.org/article/79e45d08ea3e46b7b85163877c8ff5a3
Autor:
Hugo Bisio, Rouaa Ben Chaabene, Ricarda Sabitzki, Bohumil Maco, Jean Baptiste Marq, Tim-Wolf Gilberger, Tobias Spielmann, Dominique Soldati-Favre
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Apicomplexans are obligate intracellular parasites harboring three sets of unique secretory organelles termed micronemes, rhoptries, and dense granules that are dedicated to the establishment of infection in the host cell. Apicomplexans rely
Externí odkaz:
https://doaj.org/article/83dfa7b17b2347c98d8759d52872bd43
Autor:
Ricarda Sabitzki, Marius Schmitt, Sven Flemming, Ernst Jonscher, Katharina Höhn, Ulrike Fröhlke, Tobias Spielmann
Vesicular trafficking, including secretion and endocytosis, plays fundamental roles in the unique biology ofP. falciparumblood-stage parasites. Endocytosis of host cell cytosol (HCC) provides nutrients and room for parasite growth and is critical for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4792ce810819dc66e8d59581db905c4f
https://doi.org/10.1101/2023.04.05.535711
https://doi.org/10.1101/2023.04.05.535711
Autor:
Jessica Kimmel, Marius Schmitt, Alexej Sinner, Pascal Jansen, Sheila Mainye, Gala Ramón-Zamorano, Christa Geeke Toenhake, Jan Stephan Wichers, Jakob Cronshagen, Ricarda Sabitzki, Paolo Mesén-Ramírez, Hannah Michaela Behrens, Richárd Bártfai, Tobias Spielmann
Taxa-specific proteins are key determinants defining the biology of all organisms and represent prime drug targets in pathogens. However, lacking comparability with proteins in other lineages makes them particularly difficult to study. In malaria par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c43c87faf2068491bb7d23b25482e1f1
https://doi.org/10.1101/2022.07.07.499005
https://doi.org/10.1101/2022.07.07.499005
Publikováno v:
Trends in parasitology. 36(6)
Endocytosis is critical for many functions in eukaryotic cells. Uptake of host cell cytosol, an indispensable endocytic process in malaria blood-stage parasites, has been known for a long time. However, it is only recently that the proteins involved
Autor:
Wieteke A. M. Hoeijmakers, Alexandra Blancke Soares, Ulrike Fröhlke, Sabine Schmidt, Hendrik Herrmann, Paolo Mesén-Ramírez, Sven Flemming, Bärbel Bergmann, Sarah Scharf, Ernst Jonscher, Ricarda Sabitzki, Tobias Spielmann, Christa Geeke Toenhake, Jakob Birnbaum, Richárd Bártfai, Marius Schmitt
Publikováno v:
Science, 367, 6473, pp. 51-59
Science, 367, 51-59
Science, 367, 51-59
An artemisinin resistance mechanism Species of the malaria parasite Plasmodium live in red blood cells and possess a highly conserved gene called kelch13 . Single point mutations in this gene are associated with resistance to the frontline artemisini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee08cf2c64ddd134e53fa052b79c7763
https://hdl.handle.net/2066/216019
https://hdl.handle.net/2066/216019
Autor:
Katharina Höhn, Sven Flemming, Bärbel Bergmann, Ricarda Sabitzki, Tobias Spielmann, Nick Reichard, Jakob Birnbaum, Ernst Jonscher, Marius Schmitt
Publikováno v:
Cell hostmicrobe. 25(1)
Summary During development in human erythrocytes, the malaria parasite Plasmodium falciparum internalizes a large part of the cellular content of the host cell. The internalized cytosol, consisting largely of hemoglobin, is transported to the parasit