Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Ricarda Richter"'
Autor:
Franziska Nadler, Elena Lavdovskaia, Angelique Krempler, Luis Daniel Cruz-Zaragoza, Sven Dennerlein, Ricarda Richter-Dennerlein
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
How translation termination is achieved for the non-conventional mtDNA-encoded COX1 and ND6 was so far unknown. Here, Nadler et al. address this question by assessing the functions and specificity of the mitochondrial release factors mtRF1 and mtRF1a
Externí odkaz:
https://doaj.org/article/f0f2a7801a014f1185b2ea5d754c0af1
Autor:
Nicole Kleiber, Nicolas Lemus-Diaz, Carina Stiller, Marleen Heinrichs, Mandy Mong-Quyen Mai, Philipp Hackert, Ricarda Richter-Dennerlein, Claudia Höbartner, Katherine E. Bohnsack, Markus T. Bohnsack
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
RNA modifications are key regulators of RNA functions. Here, the authors identify METTL8 as the enzyme installing m3C32 in mitochondrial tRNAThr/Ser(UCN). Lack of these modifications affects tRNA structure and impairs mitochondrial translation.
Externí odkaz:
https://doaj.org/article/b66a7c73278d4acdb1a5947679641b80
Autor:
Hauke S. Hillen, Elena Lavdovskaia, Franziska Nadler, Elisa Hanitsch, Andreas Linden, Katherine E. Bohnsack, Henning Urlaub, Ricarda Richter-Dennerlein
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Maturation of the ribosomal peptidyl transferase center (PTC) is mediated by universally conserved GTPases. Here, cryo-EM structures of mitochondrial ribosomal large subunit assembly intermediates and of mature ribosomes offer insight into the roles
Externí odkaz:
https://doaj.org/article/bc353a11e2254ccf9d5c1524e48f6a3c
Autor:
Sven Dennerlein, Sabine Poerschke, Silke Oeljeklaus, Cong Wang, Ricarda Richter-Dennerlein, Johannes Sattmann, Diana Bauermeister, Elisa Hanitsch, Stefan Stoldt, Thomas Langer, Stefan Jakobs, Bettina Warscheid, Peter Rehling
Publikováno v:
eLife, Vol 10 (2021)
Human mitochondria express a genome that encodes thirteen core subunits of the oxidative phosphorylation system (OXPHOS). These proteins insert into the inner membrane co-translationally. Therefore, mitochondrial ribosomes engage with the OXA1L-inser
Externí odkaz:
https://doaj.org/article/e8625a3117ca49bd95b34fa7d3c7007d
Autor:
Abhishek Aich, Cong Wang, Arpita Chowdhury, Christin Ronsör, David Pacheu-Grau, Ricarda Richter-Dennerlein, Sven Dennerlein, Peter Rehling
Publikováno v:
eLife, Vol 7 (2018)
Cytochrome c oxidase of the mitochondrial oxidative phosphorylation system reduces molecular oxygen with redox equivalent-derived electrons. The conserved mitochondrial-encoded COX1- and COX2-subunits are the heme- and copper-center containing core s
Externí odkaz:
https://doaj.org/article/56ef4f043956409097d51c5990eae926
Publikováno v:
FEBS Letters
Mitochondria are the powerhouses of the cell as they produce the majority of ATP with their oxidative phosphorylation (OXPHOS) machinery. The OXPHOS system is composed of the F1Fo ATP synthase and four mitochondrial respiratory chain complexes, the t
Publikováno v:
RNA Biology
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The universally conserved process of protein biosynthesis is crucial for maintaining cellular homoeostasis and in eukaryotes, mitochondrial translation is essential for aerobic energy production. Mitochondrial ribosomes (mitoribosomes) are highly spe
Publikováno v:
Trends Cell Biol
Mitoribosomes catalyze essential protein synthesis within mitochondria. Mitoribosome biogenesis is assisted by an increasing number of assembly factors, among which guanosine triphosphate hydrolases (GTPases) are the most abundant class. Here, we wil
Publikováno v:
Trends in Cell Biology
Final maturation steps during ribosome biogenesis require the assistance of assembly and quality control factors to ensure the folding of rRNA and proteins into a functional translation machinery. Here we integrate several recent structural snapshots
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62595344e65fa9f6a2d9c89bc7934e76
https://hdl.handle.net/21.11116/0000-000A-B881-421.11116/0000-000A-B87F-9
https://hdl.handle.net/21.11116/0000-000A-B881-421.11116/0000-000A-B87F-9
Publikováno v:
BIOspektrum. 26:16-19
The biogenesis and function of the mitoribosome is of central importance as mutations in the respective genes of translation factors, mitoribosomal proteins and ribosome assembly factors lead to impaired mitochondrial translation, oxidative phosphory