Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ric Broadhurst"'
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 1, Pp 63-70 (2004)
Lipoprotein[a] (Lp[a]) is assembled by a two-step process involving an initial lysine-dependent binding between apolipoprotein B-100 (apoB-100) and apolipoprotein[a] (apo[a]) that facilitates the formation of a disulphide bond between apoB-100Cys4,32
Externí odkaz:
https://doaj.org/article/080c5cf7be644712a150db28e007f71f
Autor:
Jan Sprosen, Vanessa M. Cave, Ric Broadhurst, Sarah C. Finch, Nicola G. Webb, D. Tim Harwood, Jeane Nicolas, Michael J. Boundy, John S. Munday
Publikováno v:
Toxins
Volume 13
Issue 9
Toxins, Vol 13, Iss 627, p 627 (2021)
Volume 13
Issue 9
Toxins, Vol 13, Iss 627, p 627 (2021)
Regulatory limits for shellfish toxins are required to protect human health. Often these limits are set using only acute toxicity data, which is significant, as in some communities, shellfish makes up a large proportion of their daily diet and can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a28de3a316f1a2d0c8bc6f4e5d75cb
Autor:
Björn Oback, Götz Laible, Jürgen Bode, Ric Broadhurst, Sabine Bruszies, Stefan Wagner, Judi McCracken, David N. Wells
Publikováno v:
Molecular Biology Reports. 46:1737-1746
Episomal plasmids based on a scaffold/matrix attachment region (S/MAR) are extrachromosomal DNA entities that replicate once per cell cycle and are stably maintained in cells or tissue. We generated minicircles, episomal plasmids devoid of bacterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ba787694d9c7f61b0146986a1ef03f
https://doi.org/10.1007/s11033-019-04624-x
https://doi.org/10.1007/s11033-019-04624-x
Publikováno v:
Developmental Biology. 397:77-88
The ETS superfamily transcription factors Elf5 and Ets2 have both been implicated in the maintenance of the extraembryonic ectoderm (ExE) of the mouse embryo. While homozygous mutants of either gene result in various degrees of ExE tissue loss, heter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f5ede0caf3029dda6fb948364b30f3
https://doi.org/10.1016/j.ydbio.2014.10.011
https://doi.org/10.1016/j.ydbio.2014.10.011
Autor:
Chao Tong, Joanna L. Stanley, Mark H. Vickers, Philip N. Baker, Hongbo Qi, Xinyang Yu, Hua Zhang, Jasmine F. Plows, Ric Broadhurst
Publikováno v:
Scientific Reports
Treatment options for gestational diabetes (GDM) are limited. In order to better understand mechanisms and improve treatments, appropriate animal models of GDM are crucial. Heterozygous db mice (db/+) present with glucose intolerance, insulin resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da7d90547700bb938d7f9873fe5b063
Autor:
David Scott, Phil L'Huillier, Garth J. S. Cooper, Ric Broadhurst, Chathurini Fernando, S. Reddy, Gordana Prijic, Shaoping Zhang, Kerry M. Loomes, Anthony R. J. Phillips, Jacqueline F. Aitken
Publikováno v:
Diabetes
OBJECTIVE Aggregation of human amylin/islet amyloid polypeptide (hA/hIAPP) into small soluble β-sheet–containing oligomers is linked to islet β-cell degeneration and the pathogenesis of type 2 diabetes. Here, we used tetracycline, which modifies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d53e6eafe7993bfa716b641deaf2dbc
https://doi.org/10.2337/db09-0548
https://doi.org/10.2337/db09-0548
Autor:
Kathleen G. Mountjoy, Ric Broadhurst, C.-S. Jenny Wu, Philip B. Daniel, Chathurini Fernando, Rebecca N. Marnane
Publikováno v:
Molecular and Cellular Endocrinology. 239:63-71
The melanocortin 4 receptor (MC4R) plays a critical role in the regulation of energy homeostasis, and the MC4R knockout mouse and humans with MC4R defective mutations in only one allele indicate that there is a gene dosage effect. Alterations in gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14b52bae15255d9b57abe4811e41f7c
https://doi.org/10.1016/j.mce.2005.03.013
https://doi.org/10.1016/j.mce.2005.03.013
Autor:
Ric Broadhurst, Peter L. Pfeffer, Helen W. Davey, Martyn Donnison, Phil L'Huillier, Angela Beaton
Publikováno v:
Development. 132:2299-2308
The extraembryonic ectoderm (ExE) is essential for mammalian placental formation and survival of the embryo in utero. We have obtained a mouse model lacking the ExE, by targeted deletion of the transcription factor Elf5. Although Elf5 mutant embryos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3315539806fbd8f1fdb207cebf17b23a
https://doi.org/10.1242/dev.01819
https://doi.org/10.1242/dev.01819
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 1, Pp 63-70 (2004)
Lipoprotein(a) (Lp(a)) is assembled by a two- step process involving an initial lysine-dependent binding between apolipoprotein B-100 (apoB-100) and apolipopro- tein(a) (apo(a)) that facilitates the formation of a disulphide bond between apoB-100Cys4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01906447bdba73f0f69700bde2489f4e
http://www.sciencedirect.com/science/article/pii/S0022227520319210
http://www.sciencedirect.com/science/article/pii/S0022227520319210
Autor:
Martyn Donnison, David N. Wells, Craig S. Smith, Peter L. Pfeffer, David J. Pearton, D.K. Berg, Ric Broadhurst
Publikováno v:
Developmental cell. 20(2)
SummaryThe trophectoderm (TE) and inner cell mass (ICM) are committed and marked by reciprocal expression of Cdx2 and Oct4 in mouse late blastocysts. We find that the TE is not committed at equivalent stages in cattle, and that bovine Cdx2 is require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23875d8934f9eeac291073d1220f4c0b
https://pubmed.ncbi.nlm.nih.gov/21316591
https://pubmed.ncbi.nlm.nih.gov/21316591