Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Rianne Wolswinkel"'
Autor:
Christiaan C. Veerman, Isabella Mengarelli, Charlotte D. Koopman, Ronald Wilders, Shirley C. van Amersfoorth, Diane Bakker, Rianne Wolswinkel, Mariam Hababa, Teun P. de Boer, Kaomei Guan, James Milnes, Elisabeth M. Lodder, Jeroen Bakkers, Arie O. Verkerk, Connie R. Bezzina
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 7 (2019)
Mutations in GNB5, encoding the G-protein β5 subunit (Gβ5), have recently been linked to a multisystem disorder that includes severe bradycardia. Here, we investigated the mechanism underlying bradycardia caused by the recessive p.S81L Gβ5 variant
Externí odkaz:
https://doaj.org/article/9a0498e951bf479a8ce5b96fc11940df
Autor:
Michiel E. Adriaens, Elisabeth M. Lodder, Aida Moreno‐Moral, Jan Šilhavý, Matthias Heinig, Charlotte Glinge, Charly Belterman, Rianne Wolswinkel, Enrico Petretto, Michal Pravenec, Carol Ann Remme, Connie R. Bezzina
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 21 (2018)
Background Electrocardiographic (ECG) parameters are regarded as intermediate phenotypes of cardiac arrhythmias. Insight into the genetic underpinnings of these parameters is expected to contribute to the understanding of cardiac arrhythmia mechanism
Externí odkaz:
https://doaj.org/article/39b77a93b0f64a358a1f2ea8aab77d1c
Autor:
Martine de Boer, Maaike te Lintel Hekkert, Jiang Chang, Bibi S. van Thiel, Leonie Martens, Maxime M. Bos, Marion G. J. de Kleijnen, Yanto Ridwan, Yanti Octavia, Elza D. van Deel, Lau A. Blonden, Renata M. C. Brandt, Sander Barnhoorn, Paula K. Bautista‐Niño, Ilona Krabbendam‐Peters, Rianne Wolswinkel, Banafsheh Arshi, Mohsen Ghanbari, Christian Kupatt, Leon J. de Windt, A. H. Jan Danser, Ingrid van der Pluijm, Carol Ann Remme, Monika Stoll, Joris Pothof, Anton J. M. Roks, Maryam Kavousi, Jeroen Essers, Jolanda van der Velden, Jan H. J. Hoeijmakers, Dirk J. Duncker
Publikováno v:
Aging cell, 22(3):e13768. Wiley-Blackwell
Aging Cell, 22(3):e13768. Wiley-Blackwell
Aging Cell, 22(3):e13768. Wiley-Blackwell Publishing Ltd
Aging Cell, 22(3):e13768. Wiley-Blackwell
Aging Cell, 22(3):e13768. Wiley-Blackwell Publishing Ltd
Heart failure has reached epidemic proportions in a progressively ageing population. The molecular mechanisms underlying heart failure remain elusive, but evidence indicates that DNA damage is enhanced in failing hearts. Here, we tested the hypothesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34433d6931f0ede9d081e90be6bfb43
https://pure.amc.nl/en/publications/dna-repair-in-cardiomyocytes-is-critical-for-maintaining-cardiac-function-in-mice(21e8677d-25c0-47aa-84ec-5bb5b6226d51).html
https://pure.amc.nl/en/publications/dna-repair-in-cardiomyocytes-is-critical-for-maintaining-cardiac-function-in-mice(21e8677d-25c0-47aa-84ec-5bb5b6226d51).html
Autor:
Caroline Pham, Svitlana Podliesna, Arie Verkerk, Rianne Wolswinkel, Noelia Muñoz-Martín, Marieke Veldkamp, Leander Beekman, Lisanne Wilde, Carol Ann Remme, Connie Bezzina, Elisabeth Lodder
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:83-84
Autor:
Gaetano Thiene, Leander Beekman, Sridharan Rajamani, Adrián Ruiz-Villalba, Antonius Baartscheer, Carol Ann Remme, Gerard A Marchal, Ingeborg van der Made, Esther E. Creemers, Mathilde R. Rivaud, Cristina Basso, Connie R. Bezzina, Toon A.B. van Veen, John A. Jansen, Luiz Belardinelli, Rianne Wolswinkel
Publikováno v:
Europace
EP Europace, 22(10), 1579-1589. Oxford University Press
EP Europace, 22(10), 1579-1589. Oxford University Press
Aims SCN5A mutations are associated with arrhythmia syndromes, including Brugada syndrome, long QT syndrome type 3 (LQT3), and cardiac conduction disease. Long QT syndrome type 3 patients display atrio-ventricular (AV) conduction slowing which may co
Autor:
Rajiv A Mohan, Bastiaan J. Boukens, Gerard A Marchal, Rianne Wolswinkel, Arie O. Verkerk, Carol Ann Remme
Publikováno v:
Acta physiologica (Oxford, England), 230(2):e13493. Wiley-Blackwell
Aim The voltage-gated sodium channel NaV 1.5, encoded by SCN5A, is essential for cardiac excitability and ensures proper electrical conduction. Early embryonic death has been observed in several murine models carrying homozygous Scn5amutations. We in
Autor:
Gerard A, Marchal, Arie O, Verkerk, Rajiv A, Mohan, Rianne, Wolswinkel, Bastiaan J D, Boukens, Carol Ann, Remme
Publikováno v:
Acta physiologica (Oxford, England). 230(2)
The voltage-gated sodium channel NaInvolvement of NaIn WT embryos, tetrodotoxin did not affect cardiac activation at E9.5, but slowed activation at E10.5. Accordingly, patch-clamp measurements revealed that IWe here demonstrate that Na
Autor:
Carol Ann Remme, Rianne Wolswinkel, Aida Moreno-Moral, Michiel E. Adriaens, Matthias Heinig, Jan Šilhavý, Charly N.W. Belterman, Charlotte Glinge, Connie R. Bezzina, Michal Pravenec, Enrico Petretto, Elisabeth M. Lodder
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association, 7(21):e009243. Wiley-Blackwell
Journal of the American Heart Association, 7(21):e009243. Wiley
J. Am. Heart Assoc. 7:e009243 (2018)
Journal of the American Heart Association, 7(21):e009243. Wiley-Blackwell
Journal of the American Heart Association, 7(21):e009243. Wiley
J. Am. Heart Assoc. 7:e009243 (2018)
Background Electrocardiographic ( ECG ) parameters are regarded as intermediate phenotypes of cardiac arrhythmias. Insight into the genetic underpinnings of these parameters is expected to contribute to the understanding of cardiac arrhythmia mechani
Autor:
Maarten P. van den Berg, Gerard A Marchal, Yuka Mizusawa, Arthur A.M. Wilde, Allard C. van der Wal, Roel van der Nagel, Jacques M.T. de Bakker, J. Peter van Tintelen, Michael W.T. Tanck, Connie R. Bezzina, Eline A. Nannenberg, Harold V.M. van Rijen, Luiz Belardinelli, John A. Jansen, Rianne Wolswinkel, Sridharan Rajamani, Ingeborg van der Made, Carol Ann Remme, Pieter G. Postema, Mathilde R. Rivaud, Esther E. Creemers, Toon A.B. van Veen
Publikováno v:
European Heart Journal, 39(31), 2898. Oxford University Press
European Heart Journal, 39(31), 2898-2907. Oxford University Press
European heart journal, 39(31), 2898-2907. Oxford University Press
European Heart Journal, 39(31), 2898-2907. Oxford University Press
European heart journal, 39(31), 2898-2907. Oxford University Press
Aims: Management of patients with inherited cardiac ion channelopathy is hindered by variability in disease severity and sudden cardiac death (SCD) risk. Here, we investigated the modulatory role of hypertrophy on arrhythmia and SCD risk in sodium ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c822eb9806680fcb92c11756e0960ca
https://dspace.library.uu.nl/handle/1874/371512
https://dspace.library.uu.nl/handle/1874/371512
Autor:
Ludovic Gillet, Richard Redon, Hugues Abriel, Diana Shy, Maria C. Essers, Arie O. Verkerk, Anneke M. van Mil, Rianne Wolswinkel, Jean-Sébastien Rougier, Ninda Syam, Samuel Rotman, Connie R. Bezzina, Carol Ann Remme, Jakob Ogrodnik, Roos F. Marsman, Maxime Albesa, Julien Barc
Publikováno v:
Circulation
Circulation, 130(2), 147-160. Lippincott Williams and Wilkins
Circulation, 130(2), 147-U96
Circulation, 130(2), 147-160. Lippincott Williams and Wilkins
Circulation, 130(2), 147-U96
Background— Sodium channel Na V 1.5 underlies cardiac excitability and conduction. The last 3 residues of Na V 1.5 (Ser-Ile-Val) constitute a PDZ domain–binding motif that interacts with PDZ proteins such as syntrophins and SAP97 at different loc