Výsledky vyhledávání - "Rianne P. Gorter"

Investigating demyelination, efficient remyelination and remyelination failure in organotypic cerebellar slice cultures: Workflow and practical tips

Autor: Rianne P, Gorter, Naomi S, Dijksman, Wia, Baron, Holly, Colognato

Publikováno v: Methods in cell biology. 168

Healthy myelin is essential for proper brain function. When the myelin sheath is damaged, fast saltatory impulse conduction is lost and neuronal axons become vulnerable to degeneration. Thus, regeneration of the myelin sheath by encouraging oligodend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::63e47688462b298f3ba4572e7ee4962b
https://pubmed.ncbi.nlm.nih.gov/35366978

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Human Endogenous Retrovirus Type W Envelope from Multiple Sclerosis Demyelinating Lesions Shows Unique Solubility and Antigenic Characteristics

Autor: Hervé Perron, Rianne P. Gorter, Christophe Quétard, Justine Pierquin, Sandra Amor, Benjamin Charvet, Jacques Portoukalian, Joanna Brunel, Branka Horvat

Publikováno v: Charvet, B, Pierquin, J, Brunel, J, Gorter, R, Quétard, C, Horvat, B, Amor, S, Portoukalian, J & Perron, H 2021, ' Human Endogenous Retrovirus Type W Envelope from Multiple Sclerosis Demyelinating Lesions Shows Unique Solubility and Antigenic Characteristics ', Virologica Sinica, vol. 36, no. 5, pp. 1006-1026 . https://doi.org/10.1007/s12250-021-00372-0
Virologica Sinica
Virologica Sinica, 36(5), 1006-1026

In multiple sclerosis (MS), human endogenous retrovirus W family (HERV-W) envelope protein, pHERV-W ENV, limits remyelination and induces microglia-mediated neurodegeneration. To better understand its role, we examined the soluble pHERV-W antigen fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::403af3b17cbc32ad061ada236a37a711
https://research.vumc.nl/en/publications/9dff620d-3b71-4659-9dc8-f0eb09f28317

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A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis

Autor: Rianne P. Gorter, David R. Owen, Marjolein Breur, Joy de Bruin, Cornelius K. Donat, Jodie Stephenson, Erik Nutma, Deirdre M Boucherie, Paul M. Matthews, Paul van der Valk, Sandra Amor

Publikováno v: Brain
Brain : a journal of neurology, 142(11), 3440-3455
Nutma, E, Stephenson, J A, Gorter, R P, de Bruin, J, Boucherie, D M, Donat, C K, Breur, M, van der Valk, P, Matthews, P M, Owen, D R & Amor, S 2019, ' A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis ', Brain : a journal of neurology, vol. 142, no. 11, pp. 3440-3455 . https://doi.org/10.1093/brain/awz287

Radioligands targeting the 18 kDa translocator protein (TSPO) are increasingly used to visualise inflammation in the brain. Nutma et al. report that TSPO expression in multiple sclerosis lesions originates mainly from astrocytes and microglia, but is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c294be69e125e57e4a8c7bdd478712c2
http://www.scopus.com/inward/record.url?scp=85074310069&partnerID=8YFLogxK

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Rapidly progressive amyotrophic lateral sclerosis is associated with microglial reactivity and small heat shock protein expression in reactive astrocytes

Autor: Jasper J. Anink, Jeroen A.M. Beliën, Jodie Stephenson, J. C. de Jonge, Rianne P. Gorter, Wia Baron, Caroline Mijnsbergen, Erik Nutma, M. C. Jahreiβ, Eleonora Aronica, J M van Noort, Sandra Amor

Publikováno v: Neuropathology and applied neurobiology, 45(5), 459-475. Wiley-Blackwell
Neuropathology and Applied Neurobiology, 45(5), 459-475. Wiley-Blackwell
Neuropathology and Applied Neurobiology
Gorter, R P, Stephenson, J, Nutma, E, Anink, J, de Jonge, J C, Baron, W, Jahreiβ, M C, Belien, J A M, van Noort, J M, Mijnsbergen, C, Aronica, E & Amor, S 2019, ' Rapidly progressive amyotrophic lateral sclerosis is associated with microglial reactivity and small heat shock protein expression in reactive astrocytes ', Neuropathology and Applied Neurobiology, vol. 45, no. 5, pp. 459-475 . https://doi.org/10.1111/nan.12525
Neuropathology and Applied Neurobiology, 45(5), 459-475. WILEY-BLACKWELL

AIMS: Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disease characterised by progressive loss of motor neurons, muscle weakness, spasticity, paralysis and death usually within 2-5 years of onset. Neuroinflammation is a hallmark o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0bc859e6c1c9a2c107cb494773d07b
https://research.rug.nl/en/publications/a523de00-84bd-4ba4-b937-533f88897371

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Matrix metalloproteinases shape the oligodendrocyte (niche) during development and upon demyelination

Autor: Wia Baron, Rianne P. Gorter

Publikováno v: Neuroscience Letters. 729

The oligodendrocyte lineage cell is crucial to proper brain function. During central nervous system development, oligodendrocyte progenitor cells (OPCs) migrate and proliferate to populate the entire brain and spinal cord, and subsequently differenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::577a5da6db8be010c26c4ea624cc414c
https://doi.org/10.1016/j.neulet.2020.134980

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Heat shock proteins are differentially expressed in brain and spinal cord

Autor: Erik Nutma, Sandra Amor, Rianne P. Gorter, Roy A. Quinlan, J M van Noort, M-C Jahrei, Wia Baron, P. van der Valk, J. C. de Jonge

Publikováno v: Gorter, R P, Nutma, E, Jahrei, M-C, de Jonge, J C, Quinlan, R A, van der Valk, P, van Noort, J M, Baron, W & Amor, S 2018, ' Heat shock proteins are differentially expressed in brain and spinal cord : implications for multiple sclerosis ', Clinical and Experimental Immunology, vol. 194, no. 2, pp. 137-152 . https://doi.org/10.1111/cei.13186
Clinical and Experimental Immunology, 194(2), 137-152. Wiley
Clinical and experimental immunology, 2018, Vol.194(2), pp.137-152 [Peer Reviewed Journal]
Clinical and Experimental Immunology, 194(2), 137-152. Wiley-Blackwell
Clinical and Experimental Immunology

AIMS: Multiple sclerosis (MS) is a chronic neurodegenerative disease characterised by demyelination, inflammation and neurodegeneration throughout the central nervous system. Although spinal cord pathology is an important factor contributing to disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825dd92b4cb629ecca73ec3a89242db5
https://doi.org/10.1111/cei.13186

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MMP7 cleaves remyelination-impairing fibronectin aggregates and its expression is reduced in chronic multiple sclerosis lesions

Autor: Peng Wang, Sandra Amor, Wia Baron, Jenny C. de Jonge, Chao Zhao, Dick Hoekstra, Muhammad Nazmuddin, Rianne P. Gorter

Publikováno v: Wang, P, Gorter, R P, de Jonge, J C, Nazmuddin, M, Zhao, C, Amor, S, Hoekstra, D & Baron, W 2018, ' MMP7 cleaves remyelination-impairing fibronectin aggregates and its expression is reduced in chronic multiple sclerosis lesions ', GLIA, vol. 66, no. 8, pp. 1625-1643 . https://doi.org/10.1002/glia.23328
GLIA, 66(8), 1625-1643. John Wiley and Sons Inc.
Glia, 66(8), 1625-1643. Wiley
Glia

Upon demyelination, transient expression of fibronectin precedes successful remyelination. However, in chronic demyelination observed in multiple sclerosis (MS), aggregates of fibronectin persist and contribute to remyelination failure. Accordingly,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f453572b3bfa97c80b418afdf723d78
https://hdl.handle.net/11370/a24ff773-8500-4191-8116-3073fbee92fb

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