Roadmap for Precision preclinical x-ray radiation studies

Autor: Frank Verhaegen, Karl T Butterworth, Anthony J Chalmers, Rob P Coppes, Dirk de Ruysscher, Sophie Dobiasch, John D Fenwick, Patrick V Granton, Stefan H J Heijmans, Mark A Hill, Constantinos Koumenis, Kirsten Lauber, Brian Marples, Katia Parodi, Lucas C G G Persoon, Nick Staut, Anna Subiel, Rianne D W Vaes, Stefan van Hoof, Ioannis L Verginadis, Jan J Wilkens, Kaye J Williams, George D Wilson, Ludwig J Dubois

Publikováno v: Physics in Medicine and Biology, 68(6). IOP Publishing Ltd.
Verhaegen, F, Butterworth, K T, Chalmers, A J, Coppes, R P, de Ruysscher, D, Dobiasch, S, Fenwick, J D, Granton, P V, Heijmans, S H J, Hill, M A, Koumenis, C, Lauber, K, Marples, B, Parodi, K, Persoon, L C G G, Staut, N, Subiel, A, Vaes, R D W, van Hoof, S, Verginadis, I L, Wilkens, J J, Williams, K J & Wilson, G D 2023, ' Roadmap for precision preclinical x-ray radiation studies ', Physics in Medicine and Biology, vol. 68, no. 6, 06RM01 . https://doi.org/10.1088/1361-6560/acaf45

This Roadmap paper covers the field of precision preclinical x-ray radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05103f95458dc0a4608333fb04c34423
https://cris.maastrichtuniversity.nl/en/publications/ec5c3a0a-a978-4f52-b112-e310333f3236

Preparing ductal epithelial organoids for high-spatial-resolution molecular profiling using mass spectrometry imaging

Autor: Brenda Bakker, Rianne D. W. Vaes, Merel R. Aberle, Tessa Welbers, Thomas Hankemeier, Sander S. Rensen, Steven W. M. Olde Damink, Ron M. A. Heeren

Publikováno v: Nature Protocols, 17(4), 962-979. Nature Publishing Group

Organoids are increasingly used as model systems in precision medicine, but they are delicate, making it difficult to get accurate spatial chemical information. This protocol describes how to prepare organoid samples for mass spectrometry imaging.Org

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e1feb1927f385e5e0e87b253aa3c1c
https://cris.maastrichtuniversity.nl/en/publications/2467b9af-4508-4661-9b9f-4ad8b3eb9e6d

OxLDL as an Inducer of a Metabolic Shift in Cancer Cells

Autor: Yvonne Oligschlaeger, Annemarie Westheim, Tom Houben, Tulasi Yadati, Rianne D. W. Vaes, Steven W.M. Olde Damink, Lingling Ding, Albert V. Bitorina, Ronit Shiri-Sverdlov, Jan Theys

Publikováno v: Journal of Cancer
Journal of Cancer, 12(19), 5817-5824. Ivyspring International Publisher

Recent evidence established a link between disturbed lipid metabolism and increased risk for cancer. One of the most prominent features related to disturbed lipid metabolism is an increased production of oxidized low-density-lipoproteins (oxLDL), whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768bd474665982be74f022c0c1a5ecf3
http://europepmc.org/articles/PMC8408103

Generation and initial characterization of novel tumour organoid models to study human pancreatic cancer‐induced cachexia

Autor: Marinus J. Blok, Steven W.M. Olde Damink, Rianne D. W. Vaes, Sander S. Rensen, Merel R. Aberle, David P J van Dijk, Lara R. Heij, Sylvia F Boj, Tessa T.J. Welbers

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle
Journal of cachexia, sarcopenia and muscle, 11(6), 1509-1524. Wiley

Background The majority of patients with pancreatic cancer develops cachexia. The mechanisms underlying cancer cachexia development and progression remain elusive, although tumour‐derived factors are considered to play a major role. Pancreatic tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce63441e26ce86f860e247dc69a77fd
http://europepmc.org/articles/PMC7749546

Preparing ductal epithelial organoids for high-spatial-resolution molecular profiling using mass spectrometry imaging

Autor: Brenda, Bakker, Rianne D W, Vaes, Merel R, Aberle, Tessa, Welbers, Thomas, Hankemeier, Sander S, Rensen, Steven W M, Olde Damink, Ron M A, Heeren

Publikováno v: Nature protocols. 17(4)

Organoid culture systems are self-renewing, three-dimensional (3D) models derived from pluripotent stem cells, adult derived stem cells or cancer cells that recapitulate key molecular and structural characteristics of their tissue of origin. They gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e4be477fc5c0dd2382afa19b40b3f5f9
https://pubmed.ncbi.nlm.nih.gov/35181767