Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Rianita van Onselen"'
Autor:
Pieter Venter, Rianita van Onselen
Publikováno v:
Analytical and Bioanalytical Chemistry. 415:1187-1193
The presence of antiretroviral drugs (ARVDs) in the aquatic environment poses a significant health risk to the ecosystem. The dilution of these compounds during wastewater treatment processes, followed by discharge into the environment, results in ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dff2aaa05e7dfb114e49a46a60cf187f
https://doi.org/10.1007/s00216-022-04499-1
https://doi.org/10.1007/s00216-022-04499-1
Autor:
Rianita van Onselen, T.G. Downing
Publikováno v:
Neurotoxicity Research. 39:1762-1770
Historically, reserpine was widely used as an antihypertensive drug. However, severe motor and non-motor symptoms such as dyskinesia and depression led to the discontinuation of reserpine as a first-line treatment for hypertension. Reserpine function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcb7cde54ce8ca71d33361aedd475f4e
https://doi.org/10.1007/s12640-021-00434-x
https://doi.org/10.1007/s12640-021-00434-x
Autor:
Tim G. Downing, Rianita van Onselen
Publikováno v:
Handbook of Neurotoxicity ISBN: 9783031150791
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf1bd07ee764be7790b27e273ab07cce
https://doi.org/10.1007/978-3-031-15080-7_192
https://doi.org/10.1007/978-3-031-15080-7_192
Publikováno v:
Toxicon. 222:106978
The neurotoxic, non-proteinogenic amino acid β-N-methylamino-l-alanine (BMAA) has been implicated in the development of neurodegenerative diseases; however, the mechanism(s) and mode(s) of toxicity remain unclear. Similarities in the neuropathology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf15bfca039e056c75f9f17edad15763
https://doi.org/10.1016/j.toxicon.2022.106978
https://doi.org/10.1016/j.toxicon.2022.106978
Publikováno v:
Toxins, Vol 9, Iss 12, p 400 (2017)
Misincorporation of β-N-methylamino-l-alanine (BMAA) into proteins has been proposed to be a mechanism of toxicity to explain the role of BMAA in neurodegenerative disease development. However, studies have shown that all detectable BMAA can be remo
Externí odkaz:
https://doaj.org/article/5485d307f07c4be3a4ff1e5f0586cd75
Publikováno v:
Toxicon. 168:131-139
Human dietary exposure to the environmental neurotoxin β-N-methylamino-L-alanine (BMAA) has been implicated in an increased risk of developing sporadic neurodegenerative diseases like Alzheimer's and amyotrophic lateral sclerosis. Evidence suggests
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f21c9436e4cb190bc6e6a4d26397f82
https://doi.org/10.1016/j.toxicon.2019.07.007
https://doi.org/10.1016/j.toxicon.2019.07.007
Autor:
Rianita van Onselen, T.G. Downing
Publikováno v:
Handbook of Neurotoxicity ISBN: 9783030715199
Handbook of Neurotoxicity
Handbook of Neurotoxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab03f1b1af0b61f763a65b805eafe2e9
https://doi.org/10.1007/978-3-030-71519-9_192-1
https://doi.org/10.1007/978-3-030-71519-9_192-1
Autor:
Rianita van Onselen, T.G. Downing
Publikováno v:
International journal of toxicology. 38(2)
The naturally produced, nonprotein amino acid β- N-methylamino-l-alanine (BMAA) has been proposed as a significant contributor to sporadic neurodegenerative disease development worldwide. However, the existing hypothesized mechanisms of toxicity do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8258a7b9ed8d692468019c4daaa38c5d
https://pubmed.ncbi.nlm.nih.gov/30663459
https://pubmed.ncbi.nlm.nih.gov/30663459
Publikováno v:
Toxicology and Applied Pharmacology. 403:115140
With accumulating evidence that supports the role of β-N-methylamino-l-alanine (BMAA) in neurodegeneration, it is necessary to elucidate the mechanisms and modes of BMAA toxicity so as to facilitate the search for potential preventative/therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9843e1262a5fd2c2841d8a354e8667c7
https://doi.org/10.1016/j.taap.2020.115140
https://doi.org/10.1016/j.taap.2020.115140
Publikováno v:
Toxicon. 102:55-61
β-N-methylamino-l-alanine (BMAA), is commonly found in both a free and proteinassociated form in various organisms exposed to the toxin. The long latency of development of neurodegeneration attributed to BMAA, is hypothesized to be the result of exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4d6484c742618efdc180260afe2e38
https://doi.org/10.1016/j.toxicon.2015.05.014
https://doi.org/10.1016/j.toxicon.2015.05.014