LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor

Autor: Thomas J. Montine, Rian de Laat, Jesse C. Wiley, Mark Bothwell, Mark P. Hudson, James S. Meabon

Publikováno v: Pathobiology of Aging & Age-related Diseases, Vol 5, Iss 0, Pp 1-11 (2015)
Pathobiology of Aging & Age Related Diseases
Pathobiology of Aging & Age-related Diseases; Vol 5 (2015) incl Supplements

Sequential proteolytic cleavages of amyloid-β protein precursor (AβPP) by β-secretase and γ-secretase generate amyloid β (Aβ) peptides, which are thought to contribute to Alzheimer’s disease (AD). Much of this processing occurs in endosomes f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d64093c174374e704716711449220bb
http://www.pathobiologyofaging.net/index.php/pba/article/view/25796/pdf_6

Intense and specialized dendritic localization of the fragile X mental retardation protein in binaural brainstem neurons: A comparative study in the alligator, chicken, gerbil, and human

Autor: Mark Bothwell, Randy J. Kulesza, Yuan Wang, Hitomi Sakano, Karisa Beebe, Maile R. Brown, Edwin W. Rubel, Rian de Laat

Publikováno v: Journal of Comparative Neurology. 522:2107-2128

Neuronal dendrites are structurally and functionally dynamic in response to changes in afferent activity. The fragile X mental retardation protein (FMRP) is an mRNA binding protein that regulates activity-dependent protein synthesis and morphological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83e18be015331df2b01c1d4a54f00c83
https://doi.org/10.1002/cne.23520

Developmental expression of paraoxonase 2

Autor: Judit Marsillach, Clement E. Furlong, Rian de Laat, John D. Elsworth, Khoi Dao, Toby B. Cole, Lucio G. Costa, Jacqueline M. Garrick

Publikováno v: Chemico-biological interactions. 259

Paraoxonase 2 (PON2) is a member of the paraoxonase gene family also comprising PON1 and PON3. PON2 functions as a lactonase and exhibits anti-bacterial as well as antioxidant properties. At the cellular level, PON2 localizes to the mitochondrial and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c06a6e597663e841688e59e8bf92f1a
https://pubmed.ncbi.nlm.nih.gov/27062895

LINGO-1 Protein Interacts with the p75 Neurotrophin Receptor in Intracellular Membrane Compartments*

Autor: Rian de Laat, Mark P. Hudson, James S. Meabon, Jesse C. Wiley, Mark Bothwell, Katsuaki Ieguchi

Background: LINGO-1·p75NTR·NgR complexes at the cell surface are believed to mediate responses to myelin inhibitors of axon growth. Results: LINGO-1 is intracellular and competes with NgR for binding to p75NTR. Conclusion: The existence of cell-sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449c35ee1a21a82255a461d90069d9db
https://europepmc.org/articles/PMC4392256/

379. Delivery of Human Clotting Factors By Expression from B lymphocytes Genetically Engineered Using the Sleeping Beauty Transposon System

Autor: Kendra A. Hyland, R. Scott McIvor, Rian de Laat, Mei Xu, Erik R. Olson, Scholz Matthew Rein, Herbig Eric J

Publikováno v: Molecular Therapy. 23:S151

Hemophilia A and hemophilia B are X-linked, genetic disorders that are caused by defective or deficient coagulation factor VIII and IX, respectively, resulting in the inability to form blood clots and sustained bleeding after trauma or injury. Recomb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf1699ba86c22d1b56f61c8c0b838cc
https://doi.org/10.1016/s1525-0016(16)33988-0