Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Riam Shammaa"'
Publikováno v:
BMC Musculoskeletal Disorders, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Knee osteoarthritis (OA) is a debilitating condition affecting human body biomechanics and quality of life. Current standard care for knee OA leads to trivial improvement and entails multiple adverse effects or complications. Rece
Externí odkaz:
https://doaj.org/article/62c43e582a344469b1d63b52824cfe3b
Autor:
Natasha Salame, Jean-Pierre Bikorimana, Nehme El-Hachem, Wael Saad, Mazen Kurdi, Jing Zhao, Nicoletta Eliopoulos, Riam Shammaa, Moutih Rafei
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract Background Mesenchymal stromal cells (MSCs) have been extensively used in the clinic due to their exquisite tissue repair capacity. However, they also hold promise in the field of cellular vaccination as they can behave as conditional antige
Externí odkaz:
https://doaj.org/article/fffee480623141a1968e76cc81908d9e
Autor:
Jean-Pierre Bikorimana, Nehme El-Hachem, Jamilah Abusarah, Nicoletta Eliopoulos, Sebastien Talbot, Riam Shammaa, Moutih Rafei
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105537- (2022)
Summary: Immunoproteasome-reprogrammed mesenchymal stromal cells (IRMs) can surpass dendritic cells at eliciting tumor-specific immunity. However, the current IRM vaccination regimen remains clinically unsuitable due to the relatively high dose of IR
Externí odkaz:
https://doaj.org/article/ca5732deff804308b5e2a158b4707052
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Cell therapy practices date back to the 19th century and continue to expand on investigational and investment grounds. Cell therapy includes stem cell- and non–stem cell-based, unicellular and multicellular therapies, with different immunophenotypi
Externí odkaz:
https://doaj.org/article/4b199b82483b4804886346411fff7906
Autor:
Jean-Pierre Bikorimana, Wael Saad, Jamilah Abusarah, Malak Lahrichi, Sebastien Talbot, Riam Shammaa, Moutih Rafei
Publikováno v:
Cells, Vol 11, Iss 15, p 2263 (2022)
Mesenchymal stromal cells (MSCs) are largely known for their immune-suppressive capacity, hence, their common use in the control of unwanted inflammation. However, novel concepts related to their biology, combined with the urgent need to identify MSC
Externí odkaz:
https://doaj.org/article/00e354fab5e54da09840f3f39e36829b
Autor:
Fatemeh Mardani, Wael Saad, Nehme El-Hachem, Jean-Pierre Bikorimana, Mazen Kurdi, Riam Shammaa, Sebastien Talbot, Moutih Rafei
Publikováno v:
Cells, Vol 11, Iss 11, p 1816 (2022)
Mesenchymal stromal cells (MSCs) are commonly known for their immune-suppressive abilities. However, our group provided evidence that it is possible to convert MSCs into potent antigen presenting cells (APCs) using either genetic engineering or pharm
Externí odkaz:
https://doaj.org/article/6de7ed82c2a94f1f992e47fd6cd2cf50
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Spinal degenerative joint disease (DJD) is associated with lower back pain (LBP) arising from the degeneration of intervertebral discs (IVD), facet joints, intertransversarii muscles, and interspinous ligaments among other anatomical structures. To c
Externí odkaz:
https://doaj.org/article/149d8f40dd594db49f027bd7d80b0926
Autor:
Jean-Pierre Bikorimana, Nehme El-Hachem, Abed El-Hakim El-Kadiry, Jamilah Abusarah, Natasha Salame, Riam Shammaa, Moutih Rafei
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Proteasomes are complex macromolecular structures existing in various forms to regulate a myriad of cellular processes. Besides degrading unwanted or misfolded proteins (proteostasis), distinct immune functions were ascribed for the immunoproteasome
Externí odkaz:
https://doaj.org/article/f4d828782fb14de99c62027afc06ac14
Autor:
Nehme El-Hachem, Edward Eid, Georges Nemer, Ghassan Dbaibo, Ossama Abbas, Nelly Rubeiz, Salah Zeineldine, Ghassan M. Matar, Jean-Pierre Bikorimana, Riam Shammaa, Benjamin Haibe-Kains, Mazen Kurban, Moutih Rafei
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101697- (2020)
Summary: The beginning of the 21st century has been marked by three distinct waves of zoonotic coronavirus outbreaks into the human population. The COVID-19 (coronavirus disease 2019) pandemic is caused by severe acute respiratory syndrome coronaviru
Externí odkaz:
https://doaj.org/article/dd115cc6c1074b86bc6aa8ed197296e1
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Case: An 18-year-old female patient with Systemic Lupus Erythematosus (SLE) and corticosteroid-associated extensive bilateral symptomatic knee Osteonecrosis (ON) (Ficat IV), treated with sequential intralesional injections of autologous bone marrow a
Externí odkaz:
https://doaj.org/article/211116d374c74b80befae828a9d2c04b