TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming phase 1 (safety, tolerability, pharmacokinetics and pharmacodynamics in healthy Kenyan adults)

Autor: Abouyannis, M, FitzGerald, R, Ngama, M, Mwangudzah, H, Nyambura, YK, Ngome, S, Riako, D, Babu, L, Lewa, F, Else, L, Dily Penchala, S, Orindi, B, Mumba, N, Kalama, B, Ndungu, FM, Adetifa, I, Khoo, S, Lalloo, DG, Casewell, NR, Hamaluba, M

Publikováno v: Wellcome Open Research. 7:90

Background: Snakebites affect over 5 million people each year, and over 100,000 per year die as a result. The only available treatment is antivenom, which has many shortcomings including high cost, intravenous administration, and high risk of adverse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471fe842370c943a7997d652cdf40fe7
https://doi.org/10.12688/wellcomeopenres.17682.1

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An optimisation of four SARS-CoV-2 qRT-PCR assays in a Kenyan laboratory to support the national COVID-19 rapid response teams.

Autor: Mohammed KS; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., de Laurent ZR; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Omuoyo DO; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Lewa C; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Gicheru E; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Cheruiyot R; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Bartilol B; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Mutua S; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Musyoki J; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Gumba H; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Mwacharo J; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Riako D; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Mwangi SJ; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Gichuki BM; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Nyamako L; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Karani A; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Karanja H; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Mugo D; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Gitonga JN; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Njuguna S; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Gumbi W; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Tawa B; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Tendwa M; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Cheruiyot W; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Sein Y; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Nyambu JK; Department Of Health Services, Taita-Taveta County Government, Taita-Taveta, Kenya., Patta SO; Department Of Health Services, Mombasa County Government, Mombasa, Kenya., Thani TS; Department Of Health Services, Mombasa County Government, Mombasa, Kenya., Maitha EK; Kilifi County Hospital, Kilifi, Kenya., Kitole B; Kilifi County Hospital, Kilifi, Kenya., Mwakinangu MS; Department Of Health Services, Kwale County Government, Kwale, Kenya., Muslih BS; Hola Referral Hospital, Tana River, Kenya., Otieno JO; King Fahd Lamu County Referral Hospital, Lamu, Kenya., Nyiro JU; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Kiyuka P; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Ndwiga L; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Wamae K; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Kimani D; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Makale J; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Morobe JM; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Osoti V; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Lambisia AW; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Odundo C; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Mwarumba S; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Mutunga M; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Bejon P; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya.; Nuffield Department of Medicine, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, UK., Tsofa B; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Agoti CN; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya., Ochola-Oyier LI; KEMRI-Wellcome Trust Research Programme, Kilifi, 230, Kenya.

Publikováno v: Wellcome open research [Wellcome Open Res] 2020 Jul 07; Vol. 5, pp. 162. Date of Electronic Publication: 2020 Jul 07 (Print Publication: 2020).