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Akademický článek

Human macrophages and dendritic cells can equally present MART-1 antigen to CD8(+) T cells after phagocytosis of gamma-irradiated melanoma cells.

Autor: María Marcela Barrio, Riad Abes, Marina Colombo, Gabriela Pizzurro, Charlotte Boix, María Paula Roberti, Emmanuelle Gélizé, Mariana Rodriguez-Zubieta, José Mordoh, Jean-Luc Teillaud

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e40311 (2012)

Dendritic cells (DC) can achieve cross-presentation of naturally-occurring tumor-associated antigens after phagocytosis and processing of dying tumor cells. They have been used in different clinical settings to vaccinate cancer patients. We have prev

Externí odkaz: https://doaj.org/article/6063186d4c954a6191316ff2f4298ff8

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Akademický článek

Impact of Glycosylation on Effector Functions of Therapeutic IgG

Autor: Jean-Luc Teillaud, Riad Abès

Publikováno v: Pharmaceuticals, Vol 3, Iss 1, Pp 146-157 (2010)

Human IgG has only one conserved glycosylation site located in the Cγ2 domain of the Fc region that accounts for the presence of two sugar moieties per IgG. These IgG sugar cores play a critical role in a number of IgG effector functions. In the pre

Externí odkaz: https://doaj.org/article/ba6de702c1f5425ea44ea1c55b973c38

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First-in-Human Study in Healthy Subjects with the Noncytotoxic Monoclonal Antibody OSE-127, a Strict Antagonist of IL-7Rα

Autor: Nicolas Poirier, Irène Baccelli, Lyssia Belarif, Riad Abès, Géraldine Teppaz, Caroline Mary, Sonia Poli, Claudia Fromond, Isabelle Girault, Sabrina Pengam, Emilienne Soma, Fanny De Sa, Jean-Pascal Conduzorgues, Cécile Braudeau, Regis Josien, Bram Volckaert, Dominique Costantini, Frédérique Corallo

Publikováno v: The Journal of Immunology. 210:753-763

OSE-127 is a humanized mAb targeting the IL-7Rα-chain (CD127), under development for inflammatory and autoimmune disease treatment. It is a strict antagonist of the IL-7R pathway, is not internalized by target cells, and is noncytotoxic. In this wor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ccbcfdd76529608f0e743c281d891f2
https://doi.org/10.4049/jimmunol.2200635

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Long-lasting antitumor protection by anti-CD20 antibody through cellular immune response

Autor: Emmanuelle Gélizé, Jean-Luc Teillaud, Wolf H. Fridman, Riad Abès

Publikováno v: Blood. 116:926-934

The anti-CD20 monoclonal antibody (mAb) rituximab has been used successfully for lymphoma therapy for more than 10 years. Although several direct mechanisms by which anti-CD20 mAbs act have been characterized in vitro, their specific role in clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8096314c8b5030b3c803d471e6be12
https://doi.org/10.1182/blood-2009-10-248609

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Les anticorps : mieux les connaître pour mieux s’en servir

Autor: Charles-Antoine Dutertre, Riad Abès, Jean-Luc Teillaud

Publikováno v: médecine/sciences. 25:1011-1019

L’utilisation therapeutique des anticorps monoclonaux connait une croissance exponentielle. Nos connaissances sur leur structure, en particulier celle des IgG1 largement utilisees en therapeutique, se sont considerablement accrues. Cependant, de no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5d084b419694e02699877900dfeb7cd
https://doi.org/10.1051/medsci/200925121011

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Modulation of tumor immunity by therapeutic monoclonal antibodies

Autor: Riad Abès, Jean-Luc Teillaud

Publikováno v: Cancer metastasis reviews. 30(1)

The surveillance of tumors by the immune system of cancer patients and its impact on disease progression and patient survival have been largely documented over the last years. In parallel, the use of therapeutic monoclonal antibodies (mAbs) in oncolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fc1ea099a2b8486d1925b1a19fa222
https://pubmed.ncbi.nlm.nih.gov/21267767

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Activating and inhibitory Fcgamma receptors in immunotherapy: being the actor or being the target

Autor: Riad Abès, Lauren Agnelli, Charles-Antoine Dutertre, Jean-Luc Teillaud

Publikováno v: Expert review of clinical immunology. 5(6)

Membrane Fcgamma receptors (FcgammaRs) can act either as potent activators of effector cell functions or as inhibitors of receptor-mediated cell activation following engagement by IgG antibodies bound to their target molecules. The remarkable ability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c360e3acd9cd227414dc90af27fd7730
https://pubmed.ncbi.nlm.nih.gov/20477693

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