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Autor:
Nguyen Natalie, Ernest Asante-Appiah, Manuel Chan, Nathalie Coulombe, Yves Ducharme, Mark Wrona, C. Bayly, Paul Tawa, Serge Plamondon, Kristina Dupont-Gaudet, Amandine Chefson, Jean-François Truchon, Sébastien Guiral, Louis-Charles Campeau, Joe Vacca, Sébastien Gagné, Rob Papp, Elizabeth Cauchon, Leanne Bedard, Eric Langlois, Robert Forget, Stéphane G. Ouellet, Stephanie Roy, Mélina Girardin, Jason Burch, Jean-Pierre Falgueyret, Bernard Cote, Danny Gauvreau, St-Onge Miguel, Marc Blouin, Ria Seliniotakis, Wanda Cromlish, Chun Sing Li, Amélie Roy, Smita Debnath, Youwei Yan, Denis Deschenes
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(3)
The optimization of a novel series of non-nucleoside reverse transcriptase inhibitors (NNRTI) led to the identification of pyridone 36. In cell cultures, this new NNRTI shows a superior potency profile against a range of wild type and clinically rele