Characterization of a SARS-CoV-2 Omicron BA.5 direct-contact transmission model in hamsters

Autor: Kim Handrejk, Katharina S. Schmitz, Edwin J. B. Veldhuis Kroeze, Laura L. A. van Dijk, Peter van Run, Bart Haagmans, Anne Moscona, Matteo Porotto, Rik L. de Swart, Rory D. de Vries, Melanie Rissmann

Publikováno v: npj Viruses, Vol 2, Iss 1, Pp 1-10 (2024)

Abstract As SARS-CoV-2 continues to evolve antigenically to escape vaccine- or infection-induced immunity, suitable animal models are needed to study novel interventions against viral variants. Syrian hamsters are often used because of their high sus

Externí odkaz: https://doaj.org/article/79afa63faedd454ab5087fbab9ac575d

Ex vivo fluorescence-guided resection margin assessment in breast cancer surgery using a topically applied, cathepsin-activatable imaging agent

Autor: Linders, Daan G.J., Bijlstra, Okker D., Walker, Ethan, March, Taryn L., Pool, Martin, Valentijn, A. Rob P.M., Dijkhuis, Tom H., Woltering, Jikke N., Pijl, Floor R., Noordam, Gilbert, van den Burg, Davey, van der Sijp, Joost R.M., Guicherit, Onno R., Marinelli, Andreas W.K.S., Burggraaf, Jacobus, Rissmann, Robert, Bogyo, Matthew, Hilling, Denise E., Kuppen, Peter J.K., Straight, Brian, Straver, Marieke E., Hazelbag, Hans Marten, Basilion, James P., Vahrmeijer, Alexander L.

Publikováno v: In Pharmacological Research November 2024 209

Non-Syndromic and Syndromic Defects in Children with Extracranial Germ Cell Tumors: Data of 2610 Children Registered with the German MAKEI 96/MAHO 98 Registry Compared to the General Population.

Autor: Schultewolter, Judit H.¹ (AUTHOR) s4juschu@uni-bonn.de, Rissmann, Anke² (AUTHOR) anke.rissmann@med.ovgu.de, von Schweinitz, Dietrich³ (AUTHOR) dietrich_schweinitz@hotmail.de, Frühwald, Michael⁴ (AUTHOR) michael.fruehwald@klinikum-augsburg.de, Blattmann, Claudia⁵ (AUTHOR) c.blattmann@klinikum-stuttgart.de, Fischer, Lars⁶ (AUTHOR) lars.fischer@medizin.uni-leipzig.de, Lange, Björn Sönke⁷ (AUTHOR) bjoernsoenke.lange@ukdd.de, Wessalowski, Rüdiger⁸ (AUTHOR) wessalowski@med.uni-duesseldorf.de, Fröhlich, Birgit⁹ (AUTHOR) birgit.froehlich@ukmuenster.de, Behnisch, Wolfgang¹⁰ (AUTHOR) wolfgang.behnisch@med.uni-heidelberg.de, Schmid, Irene¹¹ (AUTHOR) irene.schmid@med.uni-muenchen.de, Reinhard, Harald¹² (AUTHOR) h.reinhard@asklepios.com, Dürken, Matthias¹³ (AUTHOR) matthias.duerken@umm.de, Hundsdörfer, Patrick¹⁴ (AUTHOR) patrick.hundsdoerfer@helios-gesundheit.de, Heimbrodt, Martin¹⁵ (AUTHOR) martin.heimbrodt@ukbonn.de, Vokuhl, Christian¹⁶ (AUTHOR) christian.vokuhl@ukbonn.de, Schönberger, Stefan¹⁷ (AUTHOR) stefan.schoenberger@uk-essen.de, Schneider, Dominik T.¹⁸ (AUTHOR) dominik.schneider@klinikumdo.de, Seitz, Guido^19,20 (AUTHOR) guido.seitz@uk-gm.de, Looijenga, Leendert²¹ (AUTHOR) l.h.j.looijenga-2@prinsesmaximacentrum.nl

Publikováno v: Cancers. Jun2024, Vol. 16 Issue 11, p2157. 13p.

The oral IRAK4 inhibitors zabedosertib and BAY1830839 suppress local and systemic immune responses in a randomized trial in healthy male volunteers

Autor: Stefan J. Jodl, Wouter tenVoorde, Stefan Klein, Andrea Wagenfeld, Frank S. Zollmann, Maximilian Feldmüller, Naomi B. Klarenbeek, Digna T. deBruin, Manon A. A. Jansen, Robert Rissmann, Beate Rohde, Matthijs Moerland

Publikováno v: Clinical and Translational Science, Vol 17, Iss 3, Pp n/a-n/a (2024)

Abstract This study evaluated and characterized the pharmacological activity of the orally administered interleukin‐1 receptor‐associated kinase 4 (IRAK4) inhibitors BAY1834845 (zabedosertib) and BAY1830839 in healthy male volunteers. Participant

Externí odkaz: https://doaj.org/article/89d49a01219946438e0011ce97dc1147

Timing of Cardiac Surgical Interventions and Postoperative Mortality in Children With Severe Congenital Heart Defects Across Europe: Data From the EUROlinkCAT Study

Autor: Mads Damkjær, Ester Garne, Maria Loane, Stine K. Urhoj, Elisa Ballardini, Clara Cavero‐Carbonell, Alessio Coi, Laura García‐Villodre, Joanne Given, Mika Gissler, Anna Heino, Sue Jordan, Elizabeth Limb, Amanda J Neville, Anna Pierini, Anke Rissmann, Joachim Tan, Ieuan Scanlon, Joan K Morris

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 24 (2023)

Background The purpose of this study was to evaluate the timing of the first cardiac surgery, the number of cardiac surgeries performed, and 30‐day postoperative mortality rate for children with severe congenital heart defects (sCHDs) in their firs

Externí odkaz: https://doaj.org/article/ed67b3185a5f457e93cf8a5951905984