Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Rhys S. Allan"'
Autor:
Wing Fuk Chan, Hannah D. Coughlan, Yunshun Chen, Christine R. Keenan, Gordon K. Smyth, Andrew C. Perkins, Timothy M. Johanson, Rhys S. Allan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Stably silenced genes with methylated CpG at the promoter are refractory to current CRISPR activation systems. Here the authors create a more robust activation system, TETact that recruits DNA-demethylating TET1 with transcriptional activators.
Externí odkaz:
https://doaj.org/article/aa28af5f1a0d4589a6f38a6f04cab4f2
Autor:
Wing Fuk Chan, Hannah D. Coughlan, Jie H. S. Zhou, Christine R. Keenan, Naiara G. Bediaga, Philip D. Hodgkin, Gordon K. Smyth, Timothy M. Johanson, Rhys S. Allan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
During differentiation, chromosome conformation is remodelled to support lineage-specific transcriptional programs. Here, the authors characterise chromosome conformational changes in B lymphocytes as they differentiate into plasma cells, and provide
Externí odkaz:
https://doaj.org/article/7053b41411834244926ee8cb364e2b61
Autor:
Naiara G. Bediaga, Hannah D. Coughlan, Timothy M. Johanson, Alexandra L. Garnham, Gaetano Naselli, Jan Schröder, Liam G. Fearnley, Esther Bandala-Sanchez, Rhys S. Allan, Gordon K. Smyth, Leonard C. Harrison
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Remodelling of chromatin architecture is known to regulate gene expression and has been well characterized in cell lineage development but less so in response to cell perturbation. Activation of T cells, which triggers extensive changes in t
Externí odkaz:
https://doaj.org/article/ada7a43e1af6446698a2cc5ffd64419f
Autor:
Ashley P. Ng, Hannah D. Coughlan, Soroor Hediyeh-zadeh, Kira Behrens, Timothy M. Johanson, Michael Sze Yuan Low, Charles C. Bell, Omer Gilan, Yih-Chih Chan, Andrew J. Kueh, Thomas Boudier, Rebecca Feltham, Anna Gabrielyan, Ladina DiRago, Craig D. Hyland, Helen Ierino, Sandra Mifsud, Elizabeth Viney, Tracy Willson, Mark A. Dawson, Rhys S. Allan, Marco J. Herold, Kelly Rogers, David M. Tarlinton, Gordon K. Smyth, Melissa J. Davis, Stephen L. Nutt, Warren S. Alexander
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
B cell development is tightly regulated in a stepwise manner to ensure proper generation of repertoire diversity via somatic gene rearrangements. Here, the authors show that a transcription factor, Erg, functions at the earliest stage to critically c
Externí odkaz:
https://doaj.org/article/6cd266dc641c4e128ba4ff9c8fb14771
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In the two decades since the invention of laser-based super resolution microscopy this family of technologies has revolutionised the way life is viewed and understood. Its unparalleled resolution, speed, and accessibility makes super resolution imagi
Externí odkaz:
https://doaj.org/article/f14720d126844d92b80680aced871d2b
Autor:
Charles C. Bell, Katie A. Fennell, Yih-Chih Chan, Florian Rambow, Miriam M. Yeung, Dane Vassiliadis, Luis Lara, Paul Yeh, Luciano G. Martelotto, Aljosja Rogiers, Brandon E. Kremer, Olena Barbash, Helai P. Mohammad, Timothy M. Johanson, Marian L. Burr, Arindam Dhar, Natalie Karpinich, Luyi Tian, Dean S. Tyler, Laura MacPherson, Junwei Shi, Nathan Pinnawala, Chun Yew Fong, Anthony T. Papenfuss, Sean M. Grimmond, Sarah-Jane Dawson, Rhys S. Allan, Ryan G. Kruger, Christopher R. Vakoc, David L. Goode, Shalin H. Naik, Omer Gilan, Enid Y. N. Lam, Jean-Christophe Marine, Rab K. Prinjha, Mark A. Dawson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
There is increasing evidence that epigenetic mechanisms contribute to therapeutic resistance in cancer. Here the authors study AML patient samples and a mouse model of non-genetic resistance and find that transcriptional plasticity drives stable epig
Externí odkaz:
https://doaj.org/article/afef38c61db14a30844be963ce6499a0
Autor:
Christine R. Keenan, Michael J. Mlodzianoski, Hannah D. Coughlan, Naiara G. Bediaga, Gaetano Naselli, Erin C. Lucas, Qike Wang, Carolyn A. de Graaf, Douglas J. Hilton, Leonard C. Harrison, Gordon K. Smyth, Kelly L. Rogers, Thomas Boudier, Rhys S. Allan, Timothy M. Johanson
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102161- (2021)
Summary: The proximity pattern and radial distribution of chromosome territories within spherical nuclei are random and non-random, respectively. Whether this distribution pattern is conserved in the partitioned or lobed nuclei of polymorphonuclear c
Externí odkaz:
https://doaj.org/article/4507fe55d6fe45d69a3ecca9fe7b35b9
Autor:
Dane M. Newman, Shinya Sakaguchi, Aaron Lun, Simon Preston, Marc Pellegrini, Kseniya Khamina, Andreas Bergthaler, Stephen L. Nutt, Gordon K. Smyth, Anne K. Voss, Tim Thomas, Wilfried Ellmeier, Gabrielle T. Belz, Rhys S. Allan
Publikováno v:
Cell Reports, Vol 16, Iss 12, Pp 3311-3321 (2016)
How functionally diverse populations of pathogen-specific killer T cells are generated during an immune response remains unclear. Here, we propose that fine-tuning of CD8αβ co-receptor levels via histone acetylation plays a role in lineage fate. We
Externí odkaz:
https://doaj.org/article/c3c57588973b4e739d9d3cceeb66394a
Publikováno v:
Frontiers in Immunology, Vol 3 (2012)
Dendritic cells (DCs) are specialized antigen presenting cells that are exquisitely adapted to sense pathogens and induce the development of adaptive immune responses. They form a complex network of phenotypically and functionally distinct subsets. W
Externí odkaz:
https://doaj.org/article/0c3dc56a89cb4096a126346eb82506b0
Autor:
Wing Fuk Chan, Hannah D Coughlan, Michelle Ruhle, Nadia Iannarella, Carolina Alvarado, Joanna R Groom, Christine R Keenan, Andrew J Kueh, Adam K Wheatley, Gordon K Smyth, Rhys S Allan, Timothy M Johanson
Publikováno v:
Immunology & Cell Biology. 101:345-357
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eea8bc7d36b265e96fee8232b4e47e53
https://doi.org/10.1111/imcb.12626
https://doi.org/10.1111/imcb.12626