Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Rhys M Adams"'
Autor:
Caleb González, Joe Christian J Ray, Michael Manhart, Rhys M Adams, Dmitry Nevozhay, Alexandre V Morozov, Gábor Balázsi
Publikováno v:
Molecular Systems Biology, Vol 11, Iss 8, Pp 1-18 (2015)
Abstract Stress response genes and their regulators form networks that underlie drug resistance. These networks often have an inherent tradeoff: their expression is costly in the absence of stress, but beneficial in stress. They can quickly emerge in
Externí odkaz:
https://doaj.org/article/e7e0704efa474e2d9d4e7fed059a2ef5
Publikováno v:
eLife, Vol 5 (2016)
Despite the central role that antibodies play in the adaptive immune system and in biotechnology, much remains unknown about the quantitative relationship between an antibody’s amino acid sequence and its antigen binding affinity. Here we describe
Externí odkaz:
https://doaj.org/article/262b64699e594da586da48dd49c772e1
Autor:
Lin Chen, Javad Noorbakhsh, Rhys M Adams, Joseph Samaniego-Evans, Germaine Agollah, Dmitry Nevozhay, Jennie Kuzdzal-Fick, Pankaj Mehta, Gábor Balázsi
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 12, p e1003979 (2014)
Yeasts can form multicellular patterns as they expand on agar plates, a phenotype that requires a functional copy of the FLO11 gene. Although the biochemical and molecular requirements for such patterns have been examined, the mechanisms underlying t
Externí odkaz:
https://doaj.org/article/77f06bd69fa344fda65e4237bc9b98f9
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 4, p e1002480 (2012)
Gene expression actualizes the organismal phenotypes encoded within the genome in an environment-dependent manner. Among all encoded phenotypes, cell population growth rate (fitness) is perhaps the most important, since it determines how well-adapted
Externí odkaz:
https://doaj.org/article/70fa809107b74923ae2b472a7307004b
Affinity maturation produces antibodies that bind antigens with high specificity by accumulating mutations in the antibody sequence. Mapping out the antibody-antigen affinity landscape can give us insight into the accessible paths during this rapid e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c635a437b1239662d705c299c0e227
http://arxiv.org/abs/1712.04000
http://arxiv.org/abs/1712.04000
Repeated clinical malaria episodes are associated with modification of the immune system in children
Autor:
Magda E. Lotkowska, S Manni, Adam J. Reid, Mandy Sanders, E. P. de Villiers, Juliana Wambua, Philip Bejon, Chris I. Newbold, George Nyangweso, Mario Recker, Rhys M. Adams, John Joseph Valletta, Domtila Kimani, Y Bediako, Francis M. Ndungu, Kevin Marsh, Lin J-W., Addy Jwg., Jan Sodenkamp, Jean Langhorne, Joyce M. Ngoi, Jedidah Mwacharo, Matthew Berriman, O Kai
Publikováno v:
BMC Medicine, Vol 17, Iss 1, Pp 1-14 (2019)
BMC Medicine
BMC Medicine
The study received funding from the UK Medical Research Council, (MRC Programme grant #: MR/M003906/1). MB and AR are supported by the Wellcome Trust (Grant #: WT 206194). Background There are over 200 million reported cases of malaria each year, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2126ae06032ab0ca75ff2784098dc60d
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Publikováno v:
Cell Systems
Cell Systems, Elsevier, 2019, 8 (1), pp.86-93.e3. ⟨10.1016/j.cels.2018.12.004⟩
Cell Systems, Elsevier, 2019, 8 (1), pp.86-93.e3. ⟨10.1016/j.cels.2018.12.004⟩
Epistasis is the phenomenon by which the effect of a mutation depends on its genetic background. While it is usually defined in terms of organismal fitness, for single proteins, it must reflect physical interactions among residues. Here, we systemati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f111427ac168886bd6226e00e04c561a
https://doi.org/10.1016/j.cels.2018.12.004
https://doi.org/10.1016/j.cels.2018.12.004
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, Vol 5 (2016)
Despite the central role that antibodies play in the adaptive immune system and in biotechnology, much remains unknown about the quantitative relationship between an antibody’s amino acid sequence and its antigen binding affinity. Here we describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2510980950bb84d77199737a9a85f60b
http://arxiv.org/abs/1601.02160
http://arxiv.org/abs/1601.02160
Publikováno v:
Nucleic Acids Research
Synthetic gene networks can be used to control gene expression and cellular phenotypes in a variety of applications. In many instances, however, such networks can behave unreliably due to gene expression noise. Accordingly, there is a need to develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c8d2a2320077586150b2c12ec0d4cac
https://doi.org/10.1093/nar/gkq091
https://doi.org/10.1093/nar/gkq091
Publikováno v:
Proceedings of the National Academy of Sciences. 106:5123-5128
Although several recent studies have focused on gene autoregulation, the effects of negative feedback (NF) on gene expression are not fully understood. Our purpose here was to determine how the strength of NF regulation affects the characteristics of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64775bdb7a4f9f7b9fd87c7894d92b1c
https://doi.org/10.1073/pnas.0809901106
https://doi.org/10.1073/pnas.0809901106