Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rhys Grant"'
Autor:
Rhys Grant, Ahmed Abdelbaki, Alessia Bertoldi, Maria P. Gavilan, Jörg Mansfeld, David M. Glover, Catherine Lindon
Publikováno v:
Open Biology, Vol 8, Iss 6 (2018)
Aurora A kinase (AURKA) is a major regulator of mitosis and an important driver of cancer progression. The roles of AURKA outside of mitosis, and how these might contribute to cancer progression, are not well understood. Here, we show that a fraction
Externí odkaz:
https://doaj.org/article/56055bb871ef4aa2b57c054507b02235
Autor:
Ahmed Abdelbaki, Camilla Ascanelli, Cynthia N. Okoye, Begum Akman, Giacomo Janson, Mingwei Min, Chiara Marcozzi, Anja Hagting, Rhys Grant, Maria De Luca, Italia Anna Asteriti, Giulia Guarguaglini, Alessandro Paiardini, Catherine Lindon
Mitotic kinase Aurora A (AURKA) diverges from other kinases in its multiple active conformations that may explain its interphase roles and association with cancer, and the limited efficacy of drugs targeting the kinase pocket. Regulation of AURKA act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81a712b9078b47556ddd991abb74a9b0
https://doi.org/10.1101/2022.01.31.478464
https://doi.org/10.1101/2022.01.31.478464
Autor:
Ahmed, Abdelbaki, Camilla, Ascanelli, Cynthia N, Okoye, H Begum, Akman, Giacomo, Janson, Mingwei, Min, Chiara, Marcozzi, Anja, Hagting, Rhys, Grant, Maria, De Luca, Italia Anna, Asteriti, Giulia, Guarguaglini, Alessandro, Paiardini, Catherine, Lindon
Publikováno v:
Life science alliance. 6(2)
Mitotic kinase Aurora A (AURKA) diverges from other kinases in its multiple active conformations that may explain its interphase roles and the limited efficacy of drugs targeting the kinase pocket. Regulation of AURKA activity by the cell is critical
Autor:
H Begum Akman, Ahmed Abdelbaki, Giulia Guarguaglini, Olivier Gavet, Catherine Lindon, Marion Poteau, Rhys Grant
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
Journal of cell science (Online) (2020).
info:cnr-pdr/source/autori:Ahmed Abdelbaki, H. Begum Akman, Marion Poteau, Rhys Grant, Olivier Gavet, Giulia Guarguaglini, Catherine Lindon/titolo:AURKA destruction is decoupled from its activity at mitotic exit but essential to suppress interphase activity/doi:/rivista:Journal of cell science (Online)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
article-version (VoR) Version of Record
Journal of cell science (Online) (2020).
info:cnr-pdr/source/autori:Ahmed Abdelbaki, H. Begum Akman, Marion Poteau, Rhys Grant, Olivier Gavet, Giulia Guarguaglini, Catherine Lindon/titolo:AURKA destruction is decoupled from its activity at mitotic exit but essential to suppress interphase activity/doi:/rivista:Journal of cell science (Online)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
Activity of AURKA is controlled through multiple mechanisms including phosphorylation, ubiquitin-mediated degradation and allosteric interaction with TPX2. Activity peaks at mitosis, before AURKA is degraded during and after mitotic exit in a process
Autor:
Marion Poteau, Rhys Grant, H Begum Akman, Ahmed Abdelbaki, Giulia Guarguaglini, Catherine Lindon, Olivier Gavet
Activity of AURKA is controlled through multiple mechanisms including phosphorylation, ubiquitin-mediated degradation, and allosteric interaction with TPX2. Activity peaks at mitosis before AURKA is degraded during mitotic exit in a process strictly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a8f532a44985ebe94e25d239971cf5
https://doi.org/10.1101/850917
https://doi.org/10.1101/850917
Autor:
David M. Glover, Ahmed Abdelfattah, Jörg Mansfeld, Maria P. Gavilan, Catherine Lindon, Alessia Bertoldi, Rhys Grant
Publikováno v:
Open Biology, Vol 8, Iss 6 (2018)
Open Biology
Open Biology
Aurora A kinase (AURKA) is a major regulator of mitosis and an important driver of cancer progression. The roles of AURKA outside of mitosis, and how these might contribute to cancer progression, are not well understood. Here, we show that a fraction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600150457b5d91592cfd04a438c40adb
https://resolver.caltech.edu/CaltechAUTHORS:20200807-114540635
https://resolver.caltech.edu/CaltechAUTHORS:20200807-114540635
Autor:
Rhys Grant, Ahmed Abdelbaki, Alessia Bertoldi, Maria P Gavilan, Jörg Mansfeld, David M Glover, Catherine Lindon
Aurora A kinase (AURKA) is a major regulator of mitosis and an important driver of cancer progression. The roles of AURKA outside of mitosis, and how these might contribute to cancer progression, are not well understood. Here we show that a fraction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::268626c148943010372b30b510ff99a8
Publikováno v:
Reactome - a curated knowledgebase of biological pathways. 58
Publikováno v:
Frontiers in Oncology, Vol 5 (2016)
Frontiers in Oncology
Frontiers in Oncology
The Aurora kinases are essential regulators of mitosis in eukaryotes. In somatic cell divisions of higher eukaryotes the paralogues Aurora kinase A (AurA) and Aurora kinase B (AurB) play non-overlapping roles that depend on their distinct spatiotempo
Autor:
Zoltan, Lipinszki, Peng, Wang, Rhys, Grant, Catherine, Lindon, Nikola S, Dzhindzhev, Pier Paolo, D'Avino, Marcin R, Przewloka, David M, Glover, Vincent, Archambault
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1170
The ability to identify protein interactions is key to elucidating the molecular mechanisms of cellular processes, including mitosis and cell cycle regulation. Drosophila melanogaster, as a model system, provides powerful tools to study cell division