Zobrazeno 1 - 10 of 32 pro vyhledávání: '"Rhys G, Morgan"'
2
Akademický článek
Detecting intracellular thiol redox state in leukaemia and heterogeneous immune cell populations: An optimised protocol for digital flow cytometers
Autor: Alex J. Wadley, Rhys G. Morgan, Kate J. Heesom, Paul S. Hole, Steven J. Coles
Publikováno v: MethodsX, Vol 5, Iss , Pp 1473-1483 (2018)
Flow cytometric methods for detecting and quantifying reduced intracellular thiol content using fluorescein-5-maleimide (F5M) in viable eukaryotic cells date back to 1983 (Durand and Olive [1]). There has been little development in these methodologie
Externí odkaz: https://doaj.org/article/705c6ca9808142cca36f0c7c6650d22f
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3
Akademický článek
LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells
Autor: Rhys G. Morgan, Jenna Ridsdale, Megan Payne, Kate J. Heesom, Marieangela C. Wilson, Andrew Davidson, Alexander Greenhough, Sara Davies, Ann C. Williams, Allison Blair, Marian L. Waterman, Alex Tonks, Richard L. Darley
Publikováno v: Haematologica, Vol 104, Iss 7 (2019)
Canonical Wnt/β-catenin signaling is frequently dysregulated in myeloid leukemias and is implicated in leukemogenesis. Nuclear-localized β-catenin is indicative of active Wnt signaling and is frequently observed in acute myeloid leukemia (AML) pati
Externí odkaz: https://doaj.org/article/67f282a8773c4e4da92b6fe97861268a
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4
BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination
Autor: Christopher Parker, Adam C. Chambers, Dustin J. Flanagan, Jasmine Wing Yu Ho, Tracey J. Collard, Greg Ngo, Duncan M. Baird, Penny Timms, Rhys G. Morgan, Owen J. Sansom, Ann C. Williams
Publikováno v: Parker, C, Chambers, A C, Flanagan, D J, Ho, J W Y, Collard, T J, Ngo, G, Baird, D M, Timms, P, Morgan, R G, Sansom, O J & Williams, A C 2022, ' BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination ', DNA repair, vol. 115, 103331 . https://doi.org/10.1016/j.dnarep.2022.103331
The proto-oncogene BCL-3 is upregulated in a subset of colorectal cancers (CRC), where it has been shown to enhance tumour cell survival. However, although increased expression correlates with poor patient prognosis, the role of BCL-3 in determining
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b79364554502afec628f6dd8f54280
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5
Targeting β-catenin in acute myeloid leukaemia: past, present, and future perspectives
Autor: Megan Wagstaff, Brandon Coke, Georgia R. Hodgkiss, Rhys G. Morgan
Acute myeloid leukaemia (AML) is an aggressive disease of the bone marrow with a poor prognosis. Evidence suggests long established chemotherapeutic regimens used to treat AML are reaching the limits of their efficacy, necessitating the urgent develo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57e4404ecc9444219e65e71c060195b
http://sro.sussex.ac.uk/id/eprint/105241/1/BSR-2021-1841CR1_Merged_PDF.pdf
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7
Crosstalk between β-catenin and WT1 signaling activity in acute myeloid leukemia
Autor: Allison Blair, Erika J. Mancini, O Tsaponina, Stefan G. E. Roberts, L Milton-Harris, Amanda Jayne Tonks, G Caalim, M Payne, Richard Lawrence Darley, Kate J. Heesom, H Greenfield, Rhys G. Morgan
Publikováno v: Haematologica. 108(1)
Wnt signalling is an evolutionary conserved signal transduction pathway heavily implicated in normal development and disease. The central mediator of this pathway, β-catenin, is frequently overexpressed, mislocalised and overactive in acute myeloid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3583d5ab566ee7c5a7ccd4eaf1f4883
https://pubmed.ncbi.nlm.nih.gov/35443562
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8
Loss of BCL-3 sensitises colorectal cancer cells to DNA damage, revealing a role for BCL-3 in double strand break repair by homologous recombination
Autor: Christopher Parker, Greg H.P. Ngo, Duncan M. Baird, Owen J. Sansom, Dustin J. Flanagan, Ann C. Williams, Adam C. Chambers, Rhys G. Morgan, Tracey J Collard, Penny Timms
ObjectiveThe proto-oncogene BCL-3 is upregulated in a subset of colorectal cancers (CRC) and increased expression of the gene correlates with poor patient prognosis. The aim is to investigate whether inhibiting BCL-3 can increase the response to DNA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::743f9ae6fd320dab2383458578eecc39
https://doi.org/10.1101/2021.08.03.454995
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9
Akademický článek
The PDK1 master kinase is over-expressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts
Autor: Joanna Zabkiewicz, Lorna Pearn, Robert K. Hills, Rhys G. Morgan, Alex Tonks, Alan K. Burnett, Richard L. Darley
Publikováno v: Haematologica, Vol 99, Iss 5 (2014)
PDK1 is a master kinase that activates at least six protein kinase groups including AKT, PKC and S6K and is a potential target in the treatment of a range of malignancies. Here we show overexpression of PDK1 in over 40% of myelomonocytic acute leukem
Externí odkaz: https://doaj.org/article/4918f0a34d444548abd0899cbb4f7bb5
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10
Inhibition of GATA2 restrains cell proliferation and enhances apoptosis and chemotherapy mediated apoptosis in human GATA2 overexpressing AML cells
Autor: Alex Gibbs, Samantha Sinnadurai, Leigh-anne Thomas, Zhengke Wang, Alfonso Garcia-Valverde, Neil P. Rodrigues, Rhys G. Morgan, Allison Blair, Maria Konstantinou, Ashleigh S. Boyd, Magali Boyer, Juan Bautista Menendez-Gonzalez
Publikováno v: Menendez-Gonzalez, J B, Sinnadurai, S, Gibbs, A, Thomas, L, Konstantinou, M, Garcia-Valverde, A, Boyer, M, Wang, Z, Boyd, A S, Blair, A, Morgan, R G & Rodrigues, N P 2019, ' Inhibition of GATA2 restrains cell proliferation and enhances apoptosis and chemotherapy mediated apoptosis in human GATA2 overexpressing AML cells ', Scientific Reports, vol. 9, 12212 (2019) . https://doi.org/10.1038/s41598-019-48589-0
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports
GATA2, a zinc finger transcription factor predominantly expressed in hematopoietic cells, acts as an essential regulator of hematopoietic stem cell generation, survival and functionality. Loss and gain of GATA2 expression has been implicated in myelo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed752adc01c3daba6e99fc29f36f8c76
https://hdl.handle.net/1983/0fc9de71-230b-42b8-abd9-5194ca97349c
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