Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Rhys D, Brady"'
Autor:
Pablo M Casillas-Espinosa, Alison Anderson, Anna Harutyunyan, Crystal Li, Jiyoon Lee, Emma L Braine, Rhys D Brady, Mujun Sun, Cheng Huang, Christopher K Barlow, Anup D Shah, Ralf B Schittenhelm, Richelle Mychasiuk, Nigel C Jones, Sandy R Shultz, Terence J O'Brien
Publikováno v:
eLife, Vol 12 (2023)
There are no pharmacological disease-modifying treatments with an enduring effect to mitigate the seizures and comorbidities of established chronic temporal lobe epilepsy (TLE). This study aimed to evaluate for disease modifying effects of sodium sel
Externí odkaz:
https://doaj.org/article/4e8722171a41474ebb674b4e800efafa
Autor:
Mujun Sun, Tamara L. Baker, Campbell T. Wilson, Rhys D. Brady, Richelle Mychasiuk, Glenn R. Yamakawa, Anh Vo, Trevor Wilson, Stuart J. McDonald, Sandy R. Shultz
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Mild traumatic brain injury (mTBI) is a common and unmet clinical issue, with limited treatments available to improve recovery. The cerebrovascular system is vital to provide oxygen and nutrition to the brain, and a growing body of research indicates
Externí odkaz:
https://doaj.org/article/3e3e388f4c444415ad79dd79c2645b6c
Autor:
Rhys D. Brady, Stefanie Bird, Mujun Sun, Glenn R. Yamakawa, Brendan P. Major, Richelle Mychasiuk, Terence J. O'Brien, Stuart J. McDonald, Sandy R. Shultz
Publikováno v:
Neurotrauma Reports, Vol 2, Iss 1, Pp 330-342 (2021)
Neurodegeneration after traumatic brain injury (TBI) is increasingly recognized as a key factor contributing to poor chronic outcomes. Activation (i.e., phosphorylation) of the protein kinase R-like endoplasmic reticulum kinase (PERK) pathway has bee
Externí odkaz:
https://doaj.org/article/d42263c43b084e5d849bcdded32346bd
Autor:
Stuart J. McDonald, William T. O’Brien, Georgia F. Symons, Zhibin Chen, Jesse Bain, Brendan P. Major, Daniel Costello, Glenn Yamakawa, Mujun Sun, Rhys D. Brady, Biswadev Mitra, Richelle Mychasiuk, Terence J. O’Brien, Sandy R. Shultz
Publikováno v:
Biomarker Research, Vol 9, Iss 1, Pp 1-9 (2021)
Abstract Background Biomarkers that can objectively guide the diagnosis of sports-related concussion, and consequent return-to-play decisions, are urgently needed. In this study, we aimed to determine the temporal profile and diagnostic ability of se
Externí odkaz:
https://doaj.org/article/9ecca60453b544baa22c71ff9fafd25b
Autor:
Ker Rui Wong, Richelle Mychasiuk, Terence J. O’Brien, Sandy R. Shultz, Stuart J. McDonald, Rhys D. Brady
Publikováno v:
Bone Research, Vol 8, Iss 1, Pp 1-14 (2020)
Abstract Neurological heterotopic ossification (NHO) is a debilitating condition where bone forms in soft tissue, such as muscle surrounding the hip and knee, following an injury to the brain or spinal cord. This abnormal formation of bone can result
Externí odkaz:
https://doaj.org/article/8240ed2c6ae5451b9cd36a6e74b778ba
Autor:
Sandy R Shultz, Caroline J Taylor, Riemke Aggio-Bruce, William T O’Brien, Mujun Sun, Adrian V Cioanca, George Neocleous, Georgia F Symons, Rhys D Brady, Anandwardhan A Hardikar, Mugdha V Joglekar, Daniel M Costello, Terence J O’Brien, Riccardo Natoli, Stuart J McDonald
Publikováno v:
Biomarker Insights, Vol 17 (2022)
Introduction: Sports-related concussion (SRC) is a common form of brain injury that lacks reliable methods to guide clinical decisions. MicroRNAs (miRNAs) can influence biological processes involved in SRC, and measurement of miRNAs in biological flu
Externí odkaz:
https://doaj.org/article/6e5d1e47e8f3487faaf1d38c5e9fd355
Autor:
Ker Rui Wong, Marissa Sgro, Glenn R. Yamakawa, Crystal Li, Stuart J. McDonald, Mujun Sun, Sandy R. Shultz, Rhys D. Brady, Richelle Mychasiuk
Publikováno v:
Bone Reports, Vol 15, Iss , Pp 101123- (2021)
Dysregulation of the gut microbiome has been shown to disrupt both bone formation and bone resorption in several preclinical and clinical models. However, the role of microbiome in adolescent bone development remains poorly understood. This effect of
Externí odkaz:
https://doaj.org/article/77e0b23fed864e83b25d7fa9393d27eb
Autor:
Ker Rui Wong, William T O’Brien, Mujun Sun, Glenn Yamakawa, Terence J O’Brien, Richelle Mychasiuk, Sandy R Shultz, Stuart J McDonald, Rhys D Brady
Publikováno v:
Biomarker Insights, Vol 16 (2021)
Introduction: Serum neurofilament light (NfL) is an emerging biomarker of traumatic brain injury (TBI). However, the effect of peripheral injuries such as long bone fracture and skeletal muscle injury on serum NfL levels is unknown. Therefore, the ai
Externí odkaz:
https://doaj.org/article/28958bc4c5ce4401a11c422960c37ffe
Autor:
Rhys D. Brady, Pablo M. Casillas-Espinosa, Denes V. Agoston, Edward H. Bertram, Alaa Kamnaksh, Bridgette D. Semple, Sandy R. Shultz
Publikováno v:
Neurobiology of Disease, Vol 123, Iss , Pp 8-19 (2019)
Posttraumatic epilepsy (PTE) is one of the most debilitating and understudied consequences of traumatic brain injury (TBI). It is challenging to study the effects, underlying pathophysiology, biomarkers, and treatment of TBI and PTE purely in human p
Externí odkaz:
https://doaj.org/article/040d54ea0a0248159b467b6e2ac74915
Autor:
Louise Pham, David K. Wright, William T. O'Brien, Jesse Bain, Cheng Huang, Mujun Sun, Pablo M. Casillas-Espinosa, Anup D. Shah, Ralf B. Schittenhelm, Christopher G. Sobey, Rhys D. Brady, Terence J. O'Brien, Richelle Mychasiuk, Sandy R. Shultz, Stuart J. McDonald
Publikováno v:
Neurobiology of Disease, Vol 148, Iss , Pp 105151- (2021)
A history of mild traumatic brain injury (mTBI) is linked to a number of chronic neurological conditions, however there is still much unknown about the underlying mechanisms. To provide new insights, this study used a clinically relevant model of rep
Externí odkaz:
https://doaj.org/article/0242553506df4e8a87f3334e2abe75b1