Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Rhye Samuel Kanassatega"'
Autor:
Shane D Anderson, Asna Tabassum, Jae Kyung Yeon, Garima Sharma, Priscilla Santos, Tik Hang Soong, Yin Win Thu, Isaac Nies, Tomomi Kurita, Andrew Chandler, Abdelaziz Alsamarah, Rhye-Samuel Kanassatega, Yun L Luo, Wesley M Botello-Smith, Bradley T Andresen
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 11, p e1007719 (2020)
Angiotensin II type 1 receptor (AT1R) blockers (ARBs) are among the most prescribed drugs. However, ARB effectiveness varies widely, which may be due to non-synonymous single nucleotide polymorphisms (nsSNPs) within the AT1R gene. The AT1R coding seq
Externí odkaz:
https://doaj.org/article/9057f3767c6a46328700c2fefa4f9edc
Autor:
Rhye-Samuel Kanassatega, Thomas A. Bunch, Victoria C. Lepak, Christopher Wang, Brett A. Colson
Publikováno v:
J Mol Cell Cardiol
Cardiac myosin-binding protein C (cMyBP-C) is a thick filament-associated protein of the sarcomere and a potential therapeutic target for treating contractile dysfunction in heart failure. Mimicking the structural dynamics of phosphorylated cMyBP-C b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec407b94ee919958838e2c137ca08f4
https://europepmc.org/articles/PMC9067379/
https://europepmc.org/articles/PMC9067379/
Autor:
Garrett Hauck, Fiona Wong, Matthew M. Klass, Rhye-Samuel Kanassatega, Brett A. Colson, Jil C. Tardiff
Publikováno v:
Biophysical Journal. 122:121a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f18456ef7e0e25a69ad0b1ac1071946
https://doi.org/10.1016/j.bpj.2022.11.824
https://doi.org/10.1016/j.bpj.2022.11.824
Publikováno v:
The Journal of Biological Chemistry
Cardiac myosin–binding protein C (cMyBP-C) is a thick filament-associated protein that influences actin-myosin interactions. cMyBP-C alters myofilament structure and contractile properties in a protein kinase A (PKA) phosphorylation-dependent manne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9410920a7facdef2b9cf6ff5d1c71c95
https://doi.org/10.1074/jbc.ra119.009543
https://doi.org/10.1074/jbc.ra119.009543
Autor:
Thomas A. Bunch, Piyali Guhathakurta, Andrew R. Thompson, Brett A. Colson, David D. Thomas, Victoria C. Lepak, Rhye Samuel Kanassatega, Anna Wilson
Publikováno v:
The Journal of Biological Chemistry
Cardiac myosin-binding protein C (cMyBP-C) interacts with actin and myosin to modulate cardiac muscle contractility. These interactions are disfavored by cMyBP-C phosphorylation. Heart failure patients often display decreased cMyBP-C phosphorylation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e8b63a383fc7d22dea35788b29aa60
https://pubmed.ncbi.nlm.nih.gov/34052227
https://pubmed.ncbi.nlm.nih.gov/34052227
Autor:
Isaac Nies, Garima Sharma, Tik Hang Soong, Tomomi Kurita, Jae Kyung Yeon, Bradley T. Andresen, Asna Tabassum, Andrew Chandler, Yin Win Thu, Shane D. Anderson, Wesley M. Botello-Smith, Priscilla Santos, Yun Luo, Abdelaziz Alsamarah, Rhye-Samuel Kanassatega
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 16, Iss 11, p e1007719 (2020)
PLoS Computational Biology, Vol 16, Iss 11, p e1007719 (2020)
Angiotensin II type 1 receptor (AT1R) blockers (ARBs) are among the most prescribed drugs. However, ARB effectiveness varies widely, which may be due to non-synonymous single nucleotide polymorphisms (nsSNPs) within the AT1R gene. The AT1R coding seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5554ef34647506ed36dc0e625030dd19
https://pubmed.ncbi.nlm.nih.gov/33237899
https://pubmed.ncbi.nlm.nih.gov/33237899
Publikováno v:
Journal of Molecular and Cellular Cardiology. 125:140-148
Rationale Mutations in the gene encoding the sarcomeric protein cardiac myosin-binding protein C (cMyBP-C) are a leading cause of hypertrophic cardiomyopathy (HCM). Mouse models targeting cMyBP-C and use of recombinant proteins have been effective in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b41d815fc6ee7754ab5e12bb427c4e
https://doi.org/10.1016/j.yjmcc.2018.10.009
https://doi.org/10.1016/j.yjmcc.2018.10.009
Autor:
Jonathan P. Davis, Matthew M. Klass, Brett A. Colson, Sarah J. Lehman, Jil C. Tardiff, Rhye-Samuel Kanassatega
Publikováno v:
Biophysical Journal. 120:54a-55a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43bd652a0bd8ab7a62fc7267dcf58510
https://doi.org/10.1016/j.bpj.2020.11.566
https://doi.org/10.1016/j.bpj.2020.11.566
Autor:
Thomas A. Bunch, Rhye-Samuel Kanassatega, Brett A. Colson, Christopher Wang, Victoria C. Lepak
Publikováno v:
Biophysical Journal. 118:8a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5c81e98c9fcfbeb26f4ed09a567c27f
https://doi.org/10.1016/j.bpj.2019.11.235
https://doi.org/10.1016/j.bpj.2019.11.235
Autor:
Robert Orlando, Kevin M. Huang, Rhye-Samuel Kanassatega, Bradley T. Andresen, Mandy Liu, Ying Huang, Steven Yeung, Edwin K. Jackson, Arvind Thakkar, Andy Chang, Cyrus Parsa
Publikováno v:
Cancer Prevention Research. 8:27-36
The stress-related catecholamine hormones and the α- and β-adrenergic receptors (α- and β-AR) may affect carcinogenesis. The β-AR GRK/β-arrestin biased agonist carvedilol can induce β-AR–mediated transactivation of the EGFR. The initial purp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504b2e4c525e2ea6b777fd44eaba2049
https://doi.org/10.1158/1940-6207.capr-14-0193
https://doi.org/10.1158/1940-6207.capr-14-0193