Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Rhushikesh A. Kulkarni"'
Autor:
Alec G. Trub, Gregory R. Wagner, Kristin A. Anderson, Scott B. Crown, Guo-Fang Zhang, J. Will Thompson, Olga R. Ilkayeva, Robert D. Stevens, Paul A. Grimsrud, Rhushikesh A. Kulkarni, Donald S. Backos, Jordan L. Meier, Matthew D. Hirschey
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Statin therapy is associated with numerous cellular effects. Here, the authors show that statin treatment increases post-translational modifications on fatty acid synthase in the active site, revealing communication between the cholesterol and lipid
Externí odkaz:
https://doaj.org/article/6da5de5206424c06a24ccdd0b2b403ff
Autor:
Chandrasekhar Mushti, W. Marston Linehan, Sarah E. Bergholtz, Daniel R. Crooks, Stephen J. Lockett, Jordan L. Meier, Andrew N. Lane, Chloe A. Briney, Rolf E. Swenson, Teresa W.-M. Fan, Rhushikesh A. Kulkarni
Publikováno v:
Chembiochem
Dysregulated metabolism can fuel cancer by altering the production of bioenergetic building blocks and directly stimulating oncogenic gene expression programs. However, relatively few optical methods for the direct study of metabolites in cells exist
Lysine malonylation is a recently characterized posttranslational modification involved in the regulation of energy metabolism and gene expression. Two unique features of this posttranslational modification are its negative charge and potential susce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f51ee5571fe3e4b234a92dbbbd3b5e0
https://doi.org/10.1101/2020.08.23.263285
https://doi.org/10.1101/2020.08.23.263285
Autor:
Aline Broch, Gabriel Kline, Ki-Hoon Kim, Peter C.W. Kim, Martin J. Schnermann, Roger R. Nani, Jung-Man Namgoong, Rhushikesh A. Kulkarni, Jordan L. Meier, Jaepyeong Cha, Michael Luciano
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:2741-2745
Surgical methods guided by exogenous fluorescent markers have the potential to define tissue types in real time. Small molecule dyes with efficient and selective renal clearance could enable visualization of the ureter during surgical procedures invo
Publikováno v:
Curr Opin Chem Biol
Altered metabolite levels are now well-established to drive epigenetic changes in development and disease. However, in many cases the specific protein–metabolite interactions that underlie this process remain enigmatic. In this review, we make the
Autor:
Eranthie Weerapana, Chloe A. Briney, Arissa E Bavari, Laurence Florens, Sarah E. Bergholtz, Rhushikesh A. Kulkarni, Michaella J. Levy, Michael P. Washburn, Daniel W. Bak, Darmood Wei, Aktan Alpsoy, Jonathan H. Shrimp, W. Marston Linehan, Emily C. Dykhuizen, Jordan L. Meier, Abigail L. Thorpe, Norma Frizzell
Hereditary cancer disorders often provide an important window into novel mechanisms supporting tumor growth and survival. Understanding these mechanisms and developing biomarkers to identify their presence thus represents a vital goal. Towards this g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5640889de2c600f3be01fa9c0a596f25
Autor:
Wilson R. Sinclair, Ian A. Blair, Jonathan H. Shrimp, Thomas Zengeya, Andrew J. Worth, Jordan L. Meier, Julie M. Garlick, Rhushikesh A. Kulkarni, Nathaniel W. Snyder, Hans Luecke
Publikováno v:
Chemical Science
A systematically designed panel of biorthogonal pro-metabolites was synthesized and evaluated as agents for tracing cellular short chain fatty acylation.
Short chain fatty acids (SCFAs) play a central role in health and disease. One function of
Short chain fatty acids (SCFAs) play a central role in health and disease. One function of
Autor:
Rhushikesh A. Kulkarni, Sarah E. Bergholtz, Daniel W. Bak, Chloe A. Briney, Jordan L. Meier, W. Marston Linehan, Eranthie Weerapana, David Wei, Jonathan H. Shrimp
Publikováno v:
Cancer Research. 79:2759-2759
Dysregulated metabolism is a feature of many diseases, including cancer. In addition to providing energy and building blocks to growing cells, altered metabolism can assist in tumor growth by producing “oncometabolites”. For example, in hereditar
Autor:
Chandrasekhar Mushti, Stephen J. Lockett, Daniel R. Crooks, Rhushikesh A. Kulkarni, W. Marston Linehan, Jordan L. Meier, Chloe A. Briney, Sarah E. Bergholtz, Rolf E. Swenson
Publikováno v:
Cancer Research. 79:2760-2760
Dysregulated metabolism is an important marker of many disease states, including cancer. For example, in hereditary leiomyomatosis and renal cell cancer (HLRCC), inactivating mutations in fumarate hydratase (FH) lead to accumulation of high levels of
Autor:
W. Marston Linehan, Teresa W.-M. Fan, Chloe A. Briney, Rolf E. Swenson, Sarah E. Bergholtz, Rhushikesh A. Kulkarni, Andrew N. Lane, Daniel R. Crooks, Stephen J. Lockett, Jordan L. Meier, Chandrasekhar Mushti
Publikováno v:
ChemBioChem. 20:309-309