Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Rhonda Porche-Sorbet"'
Autor:
Katsuyuki Saito, Rhonda Porche-Sorbet, Xiao Yang, Rick Berry, Victoria Swamidass, Brian Duffy, Jessica Hoisington-Lopez, Robi D. Mitra, MariaLynn Crosby, Chang Liu
Publikováno v:
Human immunology. 82(4)
Nanopore sequencing has been investigated as a rapid and cost-efficient option for HLA typing in recent years. Despite the lower raw read accuracy, encouraging typing accuracy has been reported, and long reads from the platform offer additional benef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4e90eceb65f1a594596ca628d30540
https://pubmed.ncbi.nlm.nih.gov/33612390
https://pubmed.ncbi.nlm.nih.gov/33612390
Autor:
Wesley Hollomon, Gina Hyun, Noor Al-Hammadi, Rhonda Porche-Sorbet, Amir K. Jaffer, Juan Li, Charles S. Eby, Victor G. Davila-Roman, Anna M. Thompson, Brian F. Gage, Lynnae Napoli, Brandi De Vore Whipple, J. Philip Miller, Jeffrey L. Anderson, Robert L. Barrack, Robert C. Pendleton, Ryan M. Nunley, Gerard Moskowitz, Kerri Merritt, Tomás Rodriguez, Gwendolyn A. McMillin, Anne R. Bass, H. Lin, Scott C. Woller, Scott M. Stevens, Cristi R. King
Importance The optimal international normalized ratio (INR) to prevent venous thromboembolism (VTE) in warfarin-treated patients with recent arthroplasty is unknown. Objective To determine the safety and efficacy of a target INR of 1.8 vs 2.5 for VTE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f096776e47f2c7e97301a6b53f933338
https://europepmc.org/articles/PMC6724181/
https://europepmc.org/articles/PMC6724181/
Autor:
Hong Lu, Jing Pan, Rhonda Porche-Sorbet, Charles S. Eby, Xiaodong Zhou, Peter Weiser, Lijuan Zhang, Yi Qian, Fei F. Shih
Publikováno v:
Clinical and Applied Thrombosis/Hemostasis. 16:251-260
Heparin-induced thrombocytopenia with thrombosis (HITT) is the most severe side effect of heparin administration. Patients with HITT may die or have permanent sequelae such as stroke or limb amputation. Contaminated heparin is associated with anaphyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddb3a75ea5fb9b3ce0f78e18a00b2c0b
https://doi.org/10.1177/1076029610362072
https://doi.org/10.1177/1076029610362072
Autor:
Daniel C. Koboldt, Charles S. Eby, Paul E. Milligan, Howard L. McLeod, R D Miller, Gloria R. Grice, P A Lenzini, M Crankshaw, Paul M. Ridker, Brian F. Gage, Rhonda Porche-Sorbet, Larisa H. Cavallari, Shitalben R. Patel, Elena Deych, Cristi R. King, Deepak Voora
Publikováno v:
Clinical Pharmacology & Therapeutics. 87:445-451
Warfarin demonstrates a wide interindividual variability in response that is mediated partly by variants in cytochrome P450 2C9 (CYP2C9) and vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1). It is not known whether variants in calumenin (CA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b356491074cd4bba55d6c6fcf6a491c2
https://doi.org/10.1038/clpt.2009.291
https://doi.org/10.1038/clpt.2009.291
Autor:
Brian F. Gage, Elena Deych, Charles S. Eby, Paul M. Ridker, Rhonda Porche-Sorbet, Paul E. Milligan, Gloria R. Grice, Petra A. Lenzini, Cristi R. King
Publikováno v:
Thrombosis and Haemostasis. 104:750-754
SummaryVia generation of vitamin K-dependent proteins, gamma-glutamyl carboxylase (GGCX) plays a critical role in the vitamin K cycle. Single nucleotide polymorphisms (SNPs) in GGCX, therefore, may affect dosing of the vitamin K antagonist, warfarin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::396a6baa51a03923755dbb4f9bbc8692
https://doi.org/10.1160/th09-11-0763
https://doi.org/10.1160/th09-11-0763
Autor:
Cristi R. King, Rhonda Porche-Sorbet, Paul M. Ridker, Brian F. Gage, Yannick Renaud, Michael S. Phillips, Charles S. Eby
Publikováno v:
American Journal of Clinical Pathology. 129:876-883
Initiation of warfarin therapy is associated with bleeding owing to its narrow therapeutic window and unpredictable therapeutic dose. Pharmacogenetic-based dosing algorithms can improve accuracy of initial warfarin dosing but require rapid genotyping
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5637462ed8509366d766aa69615ca6ed
https://doi.org/10.1309/1e34uapr06pj6hml
https://doi.org/10.1309/1e34uapr06pj6hml
Autor:
Vonnie Landt, Rhonda Porche-Sorbet, Brian K. Dieckgraefe, Courtney W. Houchen, Dan L. Crimmins, Shrikant Anant, Jack H. Ladenson
Publikováno v:
Journal of Investigative Medicine. 50:421-434
Background The pathophysiology of inflammatory bowel disease (IBD) reflects a balance between mucosal injury related to an ongoing inflammatory process and mucosal reparative mechanisms. Proreparative mucosal factors may offer new therapeutic paradig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38bf8171907700c5e3d4a5dc060358e
https://doi.org/10.1097/00042871-200211010-00026
https://doi.org/10.1097/00042871-200211010-00026
Autor:
Joseph P. Miletich, Heather A. Daust, Amy E. Rudolph, Michael P. Mullane, Rhonda Porche-Sorbet
Publikováno v:
Thrombosis and Haemostasis. 88:756-762
SummaryTo understand the role of the factor X (fX) activation peptide (AP), a deletion mutagenesis approach was employed. Two single-chain, variant enzymes were generated in which 41 residues were deleted from the AP: fXdes-137-183 and fXdes-137-183;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae0a92c85063d4de532e35ff4fd13a38
https://doi.org/10.1055/s-0037-1613298
https://doi.org/10.1055/s-0037-1613298
Publikováno v:
Journal of Biological Chemistry. 275:38774-38779
Based on homology, amino acids 326–336 (143–154 in chymotrypsin numbering) of factor X (fX) comprise a flexible surface loop, which is susceptible to self-proteolysis and influences substrate catalysis. To investigate the role of this autolysis l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56d949ca42f7a8f883654eaa38baa7d2
https://doi.org/10.1074/jbc.m004573200
https://doi.org/10.1074/jbc.m004573200
Publikováno v:
Biochemistry. 39:2861-2867
Herein we describe a recombinant factor X (fX) with a single substitution at position 347 (fXR347N). Activated fXR347N had a reduced affinity for factor Va (fVa), although the catalytic impact of fVa binding remained intact. The mutation was selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30b7ac80bb9bfe1ddcaa43a96a41325
https://doi.org/10.1021/bi992379b
https://doi.org/10.1021/bi992379b