Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Rhonda O. Deems"'
Autor:
Cheon Seung Hoon, Leonard J. Brand, Jeffrey Nadelson, Christina L. Leone, Rhonda O. Deems, Howard C. Smith, Douglas C. Knorr, Philip A. Bell, William S. Fillers, Thomas Daniel Aicher, Fell Jay Bradford, Ronald Simpson, Bork Balkan, Fraser James D, Gerald G. Kahle, Jiaping Gao
Publikováno v:
Journal of Medicinal Chemistry. 41:4556-4566
A series of substituted tetrahydropyrrolo[2,1-b]oxazol-5(6H)-ones and tetrahydropyrrolo[2,1-b]thiazol-5(6H)-ones was synthesized from amino alcohols or amino thiols and keto acids. A pharmacological model based on the results obtained with these comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb31ffd5d78f113f76722b9919a226c6
https://doi.org/10.1021/jm9803121
https://doi.org/10.1021/jm9803121
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 274:R524-R528
Increased fatty acid oxidation contributes to hyperglycemia in patients with non-insulin-dependent diabetes mellitus. To improve glucose homeostasis in these patients, we have designed a novel, reversible inhibitor of carnitine palmitoyltransferase I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef917bf3ade0e100266316344e7efdc6
https://doi.org/10.1152/ajpregu.1998.274.2.r524
https://doi.org/10.1152/ajpregu.1998.274.2.r524
Autor:
Dario A. Otero, Philip A. Bell, Jeremy G. Dain, Thomas Daniel Aicher, Jeffrey Nadelson, Robert J. Strohschein, Leonard J. Brand, Douglas C. Knorr, James E. Foley, Douglas A. Young, Gregory Raymond Bebernitz, Ronald Simpson, William S. Fillers, Rhonda O. Deems
Publikováno v:
Journal of medicinal chemistry. 42(1)
SAH 51-641 (1) is a potent hypoglycemic agent, which acts by inhibiting hepatic gluconeogenesis. It is a prodrug of 4-(2, 2-dimethyl-1-oxopropyl)benzoic acid (2) and 4-(2, 2-dimethyl-1-hydroxypropyl)benzoic acid (3), which sequester coenzyme A (CoA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744d8ab1f1a528d95ddc2bf1adb00384
https://pubmed.ncbi.nlm.nih.gov/9888840
https://pubmed.ncbi.nlm.nih.gov/9888840
Autor:
William R. Mann, Philip A. Bell, William S. Fillers, Robert C. Anderson, Michael Balestra, Fraser James D, Markus Rudin, Rhonda O. Deems, Edwin Bernard Villhauer, James E. Foley
Publikováno v:
Journal of medicinal chemistry. 38(18)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b8ff04be369119e1dceea0bb7aa902
https://pubmed.ncbi.nlm.nih.gov/7658430
https://pubmed.ncbi.nlm.nih.gov/7658430
Publikováno v:
Biochemical and biophysical research communications. 181(1)
The peptides amylin and calcitonin-gene related peptide (CGRP) have been shown to have similar effects on glycogen metabolism in vivo and in vitro. However, it is not clear whether they act via separate receptors. Peptide fragments based on the amino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec6be19e562a85759dfccdbe145385b
https://pubmed.ncbi.nlm.nih.gov/1958178
https://pubmed.ncbi.nlm.nih.gov/1958178
Publikováno v:
Biochemical and biophysical research communications. 174(2)
Although the novel pancreatic peptide amylin has been shown to induce insulin resistance and decrease glucose uptake, the mechanism of amylin's actions is unknown. The following study evaluated the effect of amylin on glycogen metabolism in isolated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356aa5a344e819ee3ff52942198631cf
https://pubmed.ncbi.nlm.nih.gov/1847052
https://pubmed.ncbi.nlm.nih.gov/1847052
Autor:
Jeremy G. Dain, W R Simpson, Robert J. Strohschein, Gregory Raymond Bebernitz, Rhonda O. Deems, Dario A. Otero
Publikováno v:
Journal of Medicinal Chemistry. 45:1150-1150
The overproduction of glucose by the liver in NIDDM patients markedly contributes to their fasting hyperglycemia and is a direct consequence of the increased oxidation of excess free fatty acids (FFA) being released from the adipocyte. 2-(1,1-Dimethy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ca9d7de3bb24b33475af3d96b7d45c
https://doi.org/10.1021/jm010571h
https://doi.org/10.1021/jm010571h