Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Rhonda Lightle"'
Autor:
Ying Li, Romuald Girard, Abhinav Srinath, Diana Vera Cruz, Cezary Ciszewski, Chang Chen, Rhonda Lightle, Sharbel Romanos, Je Yeong Sone, Thomas Moore, Dorothy DeBiasse, Agnieszka Stadnik, Justine J. Lee, Robert Shenkar, Janne Koskimäki, Miguel A. Lopez-Ramirez, Douglas A. Marchuk, Mark H. Ginsberg, Mark L. Kahn, Changbin Shi, Issam A. Awad
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Cerebral cavernous malformation (CCM) is a hemorrhagic neurovascular disease with no currently available therapeutics. Prior evidence suggests that different cell types may play a role in CCM pathogenesis. The contribution of each cell type
Externí odkaz:
https://doaj.org/article/05cc7d1857bb4df3a29deb810717fcd3
Autor:
Andrew K. Ressler, Daniel A. Snellings, Romuald Girard, Carol J. Gallione, Rhonda Lightle, Andrew S. Allen, Issam A. Awad, Douglas A. Marchuk
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract Cerebral Cavernous Malformations (CCMs) are vascular malformations of the central nervous system which can lead to moderate to severe neurological phenotypes in patients. A majority of CCM lesions are driven by a cancer-like three-hit mutati
Externí odkaz:
https://doaj.org/article/d3cb3d6a58c14cbebc6c4be7b3bcc911
Autor:
Abhinav Srinath, Bingqing Xie, Ying Li, Je Yeong Sone, Sharbel Romanos, Chang Chen, Anukriti Sharma, Sean Polster, Pieter C. Dorrestein, Kelly C. Weldon, Dorothy DeBiasse, Thomas Moore, Rhonda Lightle, Janne Koskimäki, Dongdong Zhang, Agnieszka Stadnik, Kristina Piedad, Matthew Hagan, Abdallah Shkoukani, Julián Carrión-Penagos, Dehua Bi, Le Shen, Robert Shenkar, Yuan Ji, Ashley Sidebottom, Eric Pamer, Jack A. Gilbert, Mark L. Kahn, Mark D’Souza, Dinanath Sulakhe, Issam A. Awad, Romuald Girard
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-15 (2023)
Srinath, Xie et al. analyze plasma metabolites present in patients with cerebral cavernous angiomas. Cholic acid and hypoxanthine are found in those with Cavernous Angioma disease whilst arachidonic and linoleic acids are found in Cavernous Angioma p
Externí odkaz:
https://doaj.org/article/f125c70ee54e447c80e887a9ef5a5e18
Autor:
Ying Li, Abhinav Srinath, Roberto J. Alcazar-Felix, Stephanie Hage, Akash Bindal, Rhonda Lightle, Robert Shenkar, Changbin Shi, Romuald Girard, Issam A. Awad
Publikováno v:
Brain Sciences, Vol 13, Iss 9, p 1336 (2023)
Cerebral cavernous malformation (CCM) is a common cerebrovascular malformation causing intracranial hemorrhage, seizures, and focal neurologic deficits. A unique CCM lesional inflammatory microenvironment has been shown to influence the clinical cour
Externí odkaz:
https://doaj.org/article/1e7394b03d734e489256bf278f7dabc7
Autor:
Robert Shenkar, Thomas Moore, Christian Benavides, Rhonda Lightle, Matthew R. Detter, Nicholas Hobson, Romuald Girard, Dorothy DeBiasse, Mary Patrucco, Carol Gallione, Joseph M. Zabramski, Douglas A. Marchuk, Issam A. Awad
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/0e36c7369c9c421eb326939540b15fc2
Autor:
Janne Koskimäki, Dongdong Zhang, Yan Li, Laleh Saadat, Thomas Moore, Rhonda Lightle, Sean P. Polster, Julián Carrión-Penagos, Seán B. Lyne, Hussein A. Zeineddine, Changbin Shi, Robert Shenkar, Sharbel Romanos, Kenneth Avner, Abhinav Srinath, Le Shen, Matthew R. Detter, Daniel Snellings, Ying Cao, Miguel A. Lopez-Ramirez, Gregory Fonseca, Alan T. Tang, Pieter Faber, Jorge Andrade, Mark Ginsberg, Mark L. Kahn, Douglas A. Marchuk, Romuald Girard, Issam A. Awad
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-15 (2019)
Abstract Cerebral cavernous malformations (CCMs) are dilated capillaries causing epilepsy and stroke. Inheritance of a heterozygous mutation in CCM3/PDCD10 is responsible for the most aggressive familial form of the disease. Here we studied the diffe
Externí odkaz:
https://doaj.org/article/d491481086084d3caa544cf265ff3ba4
Autor:
Wenqing Li, Virginia Tran, Iftach Shaked, Belinda Xue, Thomas Moore, Rhonda Lightle, David Kleinfeld, Issam A Awad, Mark H Ginsberg
Publikováno v:
eLife, Vol 10 (2021)
Mosaic inactivation of CCM2 in humans causes cerebral cavernous malformations (CCMs) containing adjacent dilated blood-filled multi-cavernous lesions. We used CRISPR-Cas9 mutagenesis to induce mosaic inactivation of zebrafish ccm2 resulting in a nove
Externí odkaz:
https://doaj.org/article/85d99cab3cea493b919621e96939fdf1
Autor:
Ying Li, Romuald Girard, Abhinav Srinath, Cezary Ciszewski, Chang Chen, Rhonda Lightle, Sharbel Romanos, Thom Moore, Dorothy Debiasse, Mira Antonopoulos, Akash Bindal, Heba Ali, Agnieszka Stadnik, Justine Lee, Miguel A Lopez-Ramirez, Changbin Shi, Issam A Awad
Publikováno v:
Stroke. 54
Introduction: Cavernous Angiomas (CAs) are vascular malformations characterized by clusters of blood-filled capillary spaces lined by “leaky” endothelium. While mutations in endothelial cells have long been recognized as necessary for lesion gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cf5e8d5c136abe14f99fd162e8c1063
https://doi.org/10.1161/str.54.suppl_1.tmp15
https://doi.org/10.1161/str.54.suppl_1.tmp15
Autor:
Abhinav Srinath, Akash Bindal, Thomas Moore, Ying Li, Mira Antonopoulos, Dorothy Debiasse, Yuanyuan Zha, Rhonda Lightle, Peter Pytel, Sharbel Romanos, Sean Polster, Romuald Girard, Issam A Awad
Publikováno v:
Stroke. 54
Background: Cerebral microbleeds (CMBs) are manifestations of age-related microangiopathies associated with an increased risk of hemorrhagic stroke and cognitive decline. The pathophysiology of this age-related breakdown of the neurovascular unit rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88572caca03f4b0444a3f192446d7d4b
https://doi.org/10.1161/str.54.suppl_1.tmp18
https://doi.org/10.1161/str.54.suppl_1.tmp18
Autor:
Sharbel Romanos, Abhinav Srinath, Ying Li, Chang Chen, Akash Bindal, Dorothy Debiasse, Alexey Dimov, Thomas Moore, Rhonda Lightle, Agnieszka Stadnik, Timothy Carroll, Romuald Girard, Issam A Awad
Publikováno v:
Stroke. 54
Introduction: Age-related cerebral microbleeds (CMBs) are vascular changes associated with an increased risk of intracerebral hemorrhage (ICH) and neurocognitive decline. CMBs share a strikingly similar appearance on MRI to cerebral cavernous malform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02f23bd72e4deef80607aa9453777a34
https://doi.org/10.1161/str.54.suppl_1.123
https://doi.org/10.1161/str.54.suppl_1.123