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of 14
pro vyhledávání: '"Rhonda J. Perriman"'
Correction: Rapidly evolving protointrons in Saccharomyces genomes revealed by a hungry spliceosome.
Autor:
Jason Talkish, Haller Igel, Rhonda J Perriman, Lily Shiue, Sol Katzman, Elizabeth M Munding, Robert Shelansky, John Paul Donohue, Manuel Ares
Publikováno v:
PLoS Genetics, Vol 16, Iss 5, p e1008854 (2020)
[This corrects the article DOI: 10.1371/journal.pgen.1008249.].
Externí odkaz:
https://doaj.org/article/1a41684aba164dfa8f3e47fcb7b83adb
Autor:
Jason Talkish, Haller Igel, Rhonda J Perriman, Lily Shiue, Sol Katzman, Elizabeth M Munding, Robert Shelansky, John Paul Donohue, Manuel Ares
Publikováno v:
PLoS Genetics, Vol 15, Iss 8, p e1008249 (2019)
Introns are a prevalent feature of eukaryotic genomes, yet their origins and contributions to genome function and evolution remain mysterious. In budding yeast, repression of the highly transcribed intron-containing ribosomal protein genes (RPGs) glo
Externí odkaz:
https://doaj.org/article/bb1bc818d7cc45c9ab1f236047b04be5
Autor:
John Paul Donohue, Manuel Ares, Rhonda J. Perriman, Jason Talkish, Haller Igel, Elizabeth M. Munding, Robert Shelansky, Lily Shiue, Sol Katzman
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 16, Iss 5, p e1008854 (2020)
PLoS Genetics, Vol 16, Iss 5, p e1008854 (2020)
Introns are a prevalent feature of eukaryotic genomes, yet their origins and contributions to genome function and evolution remain mysterious. In budding yeast, repression of the highly transcribed intron-containing ribosomal protein genes (RPGs) glo
Autor:
Robert Shelansky, Jason Talkish, Elizabeth M. Munding, Sol Katzman, Lily Shiue, Rhonda J. Perriman, Haller Igel, John Paul Donohue, Manuel Ares
Publikováno v:
PLoS Genetics, Vol 15, Iss 8, p e1008249 (2019)
PLoS genetics, vol 15, iss 8
PLoS Genetics
PLoS genetics, vol 15, iss 8
PLoS Genetics
Introns are a prevalent feature of eukaryotic genomes, yet their origins and contributions to genome function and evolution remain mysterious. In budding yeast, repression of the highly transcribed intron-containing ribosomal protein genes (RPGs) glo
Autor:
Rhonda J. Perriman, Manuel Ares
Publikováno v:
Molecular Cell. 38(3):416-427
U2 snRNA-intron branchpoint pairing is a critical step in pre-mRNA recognition by the splicing apparatus, but the mechanism by which these two RNAs engage each other is unknown. Here, we identify a U2 snRNA structure, the branchpoint-interacting stem
Autor:
Rhonda J. Perriman, Manuel Ares
Publikováno v:
Genes & Development. 14:97-107
The first ATP-dependent step in pre-mRNA splicing involves the stable binding of U2 snRNP to form the prespliceosome. We show that a prespliceosome-like complex forms in the absence of ATP in yeast extracts lacking the U2 suppressor protein CUS2. The
Autor:
R. Scott Lokey, Kerstin A. Effenberger, Rhonda J. Perriman, Manuel Ares, Walter M. Bray, Melissa S. Jurica
Publikováno v:
Effenberger, KA; Perriman, RJ; Bray, WM; Lokey, RS; Ares, M; & Jurica, MS. (2013). A high-throughput splicing assay identifies new classes of inhibitors of human and yeast spliceosomes. Journal of Biomolecular Screening, 18(9), 1110-1120. doi: 10.1177/1087057113493117. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/8w43f6w1
Journal of biomolecular screening, vol 18, iss 9
Journal of biomolecular screening, vol 18, iss 9
The spliceosome is the macromolecular machine responsible for pre-mRNA splicing, an essential step in eukaryotic gene expression. During splicing, myriad subunits join and leave the spliceosome as it works on the pre-mRNA substrate. Strikingly, there
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3102aad6385595cd5ed677661781a0e0
https://europepmc.org/articles/PMC3902173/
https://europepmc.org/articles/PMC3902173/
Autor:
Manuel Ares, John Paul Donohue, W. Samuel Fagg, Melissa S. Cline, Rhonda J. Perriman, Roland J. Nagel, Megan P. Hall, Lily Shiue
Alternative splicing contributes to muscle development, but a complete set of muscle-splicing factors and their combinatorial interactions are unknown. Previous work identified ACUAA (“STAR” motif) as an enriched intron sequence near muscle-speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08fc11f2e33c9c54c44121d962e0de07
https://europepmc.org/articles/PMC3677278/
https://europepmc.org/articles/PMC3677278/
Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicing
Autor:
Manuel Ares, Rhonda J. Perriman
Publikováno v:
Genesdevelopment. 21(7)
Nuclear pre-messenger RNA (pre-mRNA) splicing requires multiple spliceosomal small nuclear RNA (snRNA) and pre-mRNA rearrangements. Here we reveal a new snRNA conformational switch in which successive roles for two competing U2 helices, stem IIa and
Stable addition of U2 small nuclear ribonucleoprotein (snRNP) to form the prespliceosome is the first ATP-dependent step in splicing, and it requires the DEXD/H box ATPase Prp5p. However, prespliceosome formation occurs without ATP in extracts lackin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4256c491b41ca7a2eb55f0828dcfa44d
https://resolver.caltech.edu/CaltechAUTHORS:PERpnas03
https://resolver.caltech.edu/CaltechAUTHORS:PERpnas03