Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Rhonda Grebe"'
Autor:
Peng Shang, Nadezda Stepicheva, Kenneth Teel, Austin McCauley, Christopher Scott Fitting, Stacey Hose, Rhonda Grebe, Meysam Yazdankhah, Sayan Ghosh, Haitao Liu, Anastasia Strizhakova, Joseph Weiss, Imran A. Bhutto, Gerard A. Lutty, Ashwath Jayagopal, Jiang Qian, José-Alain Sahel, J. Samuel Zigler, James T. Handa, Yuri Sergeev, Raju V. S. Rajala, Simon Watkins, Debasish Sinha
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Shang et al. utilize a conditional Cryba1 knockout mouse model to demonstrate a key role for βA3/A1-crystallin in retinal pigmented epithelium. As a result of βA3/A1-crystallin deficiency, the authors report EGFR endocytosis defects and actin netwo
Externí odkaz:
https://doaj.org/article/601fb7f3dfa3458993f6399da1134e8f
Autor:
Tea Soon Park, Ludovic Zimmerlin, Rebecca Evans-Moses, Justin Thomas, Jeffrey S. Huo, Riya Kanherkar, Alice He, Nensi Ruzgar, Rhonda Grebe, Imran Bhutto, Michael Barbato, Michael A. Koldobskiy, Gerard Lutty, Elias T. Zambidis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
hPSCs in culture acquire a more naïve pluripotent state upon tankyrase inhibition. Here, the authors show that tankyrase inhibitor-regulated naïve hiPSCs from diabetic donors generate more vascular progenitors and more efficient engraftment into mo
Externí odkaz:
https://doaj.org/article/4cd3936d370a4ba1b02244ee053db93b
Autor:
Karl J. Wahlin, Julien A. Maruotti, Srinivasa R. Sripathi, John Ball, Juan M. Angueyra, Catherine Kim, Rhonda Grebe, Wei Li, Bryan W. Jones, Donald J. Zack
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract The retinal degenerative diseases, which together constitute a leading cause of hereditary blindness worldwide, are largely untreatable. Development of reliable methods to culture complex retinal tissues from human pluripotent stem cells (hP
Externí odkaz:
https://doaj.org/article/1dd261a3fd8c4e21bc9180331f614bf5
Autor:
Shaul Raviv, Kapil Bharti, Sigal Rencus-Lazar, Yamit Cohen-Tayar, Rachel Schyr, Naveh Evantal, Eran Meshorer, Alona Zilberberg, Maria Idelson, Benjamin Reubinoff, Rhonda Grebe, Rina Rosin-Arbesfeld, James Lauderdale, Gerard Lutty, Heinz Arnheiter, Ruth Ashery-Padan
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004360 (2014)
During organogenesis, PAX6 is required for establishment of various progenitor subtypes within the central nervous system, eye and pancreas. PAX6 expression is maintained in a variety of cell types within each organ, although its role in each lineage
Externí odkaz:
https://doaj.org/article/400f9a39908d49ff85ec2a79b02a748d
Autor:
Urvi Gupta, Sayan Ghosh, Callen T. Wallace, Peng Shang, Ying Xin, Archana Padmanabhan Nair, Meysam Yazdankhah, Anastasia Strizhakova, Mark A. Ross, Haitao Liu, Stacey Hose, Nadezda A. Stepicheva, Olivia Chowdhury, Mihir Nemani, Vishnu Maddipatla, Rhonda Grebe, Manjula Das, Kira L. Lathrop, José-Alain Sahel, J. Samuel Zigler, Jiang Qian, Arkasubhra Ghosh, Yuri Sergeev, James T. Handa, Claudette M. St. Croix, Debasish Sinha
Publikováno v:
Autophagy
In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here, we report that in retinal pigmented epithelial (RPE) cells, LCN2 regulates ma
Autor:
Malia M. Edwards, D. Scott McLeod, Mengxi Shen, Rhonda Grebe, Janet S. Sunness, Imran A. Bhutto, Erin McDonnell, Alexandra M. Pado, Giovanni Gregori, Philip J. Rosenfeld, Gerard A. Lutty
Publikováno v:
Investigative Opthalmology & Visual Science. 64:2
Autor:
Michael I. Barbato, Imran Ahmed Bhutto, Riya Kanherkar, Ludovic Zimmerlin, Justin Thomas, Jeffrey S. Huo, Elias T. Zambidis, Nensi Ruzgar, Tea Soon Park, G. A. Lutty, Rhonda Grebe, Michael A. Koldobskiy, Rebecca Evans-Moses, Alice He
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications
Nature Communications
Here, we report that the functionality of vascular progenitors (VP) generated from normal and disease-primed conventional human induced pluripotent stem cells (hiPSC) can be significantly improved by reversion to a tankyrase inhibitor-regulated human
Autor:
Lixia Lu, Guo-Tong Xu, Rhonda Grebe, Jiang Qian, James T. Handa, Sayan Ghosh, Debasish Sinha, Yuri V. Sergeev, Peng Shang, Jun Wan, J. Samuel Zigler, Stacey Hose, Imran Ahmed Bhutto, Rosa Puertollano, Mallika Valapala, Gerard A. Lutty
Publikováno v:
Aging Cell
Summary The dry (nonneovascular) form of age‐related macular degeneration (AMD), a leading cause of blindness in the elderly, has few, if any, treatment options at present. It is characterized by early accumulation of cellular waste products in the
Autor:
Tianqi Luo, Imran Ahmed Bhutto, Peng Shang, Meysam Yazdankhah, S. Amer Riazuddin, Nadezda A. Stepicheva, Stacey Hose, Subrata H. Mishra, Joseph Weiss, James T. Handa, Sayan Ghosh, Debasish Sinha, Gerard A. Lutty, Arkasubhra Ghosh, Rhonda Grebe, J. Samuel Zigler
Publikováno v:
Autophagy
Persistent fetal vasculature (PFV) is a human disease that results from failure of the fetal vasculature to regress normally. The regulatory mechanisms responsible for fetal vascular regression remain obscure, as does the underlying cause of regressi
Autor:
Gerard A. Lutty, Justin M. Thomas, Ludovic Zimmerlin, Jeffrey S. Huo, Nensi Ruzgar, Rebecca Evans-Moses, Rhonda Grebe, Schuyler Metzger, Elias T. Zambidis, Alice He, Imran Ahmed Bhutto, Riya Kanherkar, Tea Soon Park
Vascular regenerative therapies with conventional human induced pluripotent stem cells (hiPSC) currently remain limited by high interline variability of differentiation and poor efficiency for generating functionally transplantable vascular progenito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f5139e8ebe0cdeacdb14de27c6ee8d
https://doi.org/10.1101/678599
https://doi.org/10.1101/678599