Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Rhonda D. Wideman"'
Publikováno v:
Endocrinology and Metabolism, Vol 28, Iss 4, Pp 262-274 (2013)
Glucagon-like peptide 1 (GLP-1) is secreted from enteroendocrine L-cells in response to oral nutrient intake and elicits glucose-stimulated insulin secretion while suppressing glucagon secretion. It also slows gastric emptying, which contributes to d
Externí odkaz:
https://doaj.org/article/5ac52233ac0b4b7db38ec42b43fee2b1
Autor:
Timothy J. Kieffer, Frank K. Huynh, Rhonda D. Wideman, Roveena M. Sequeira, Scott D. Covey, Jasna Levi, Heather C. Denroche
Publikováno v:
Diabetes
OBJECTIVE Leptin therapy has been found to reverse hyperglycemia and prevent mortality in several rodent models of type 1 diabetes. Yet the mechanism of leptin-mediated reversal of hyperglycemia has not been fully defined. The liver is a key organ re
Autor:
Garth L. Warnock, Timothy J. Kieffer, Alireza Rezania, Ziliang Ao, Francis Karanu, Michael J. Riedel, Rhonda D. Wideman
Publikováno v:
Diabetes
OBJECTIVE Differentiation of human embryonic stem (hES) cells to fully developed cell types holds great therapeutic promise. Despite significant progress, the conversion of hES cells to stable, fully differentiated endocrine cells that exhibit physio
Autor:
Blair K. Gage, Rhonda D. Wideman, Travis D. Webber, Alireza Rezania, Michael J. Riedel, Timothy J. Kieffer, Robert K. Baker, Yukihiro Fujita, Francis Karanu
Publikováno v:
Differentiation. 80:130-139
Islet transplantation represents a potential cure for type 1 diabetes; however, a lack of sufficient donor material limits its clinical use. To address the shortfall of islet availability, surrogate insulin-producing cells are sought. Studies suggest
Autor:
Timothy J. Kieffer, Suraj Unniappan, Christine Donald, Virginia Gunn, Qiu-Xia Zhang, Rhonda D. Wideman, Anthony T. Cheung, Jennifer L. Wall, Travis D. Webber
Publikováno v:
Journal of Molecular Medicine. 87:703-712
Most patients with type 1 diabetes rely on multiple daily insulin injections to maintain blood glucose control. However, insulin injections carry the risk of inducing hypoglycemia and do not eliminate diabetic complications. We sought to develop and
Publikováno v:
Diabetes. 56:2744-2752
OBJECTIVE—Glucagon, which raises blood glucose levels by stimulating hepatic glucose production, is produced in α-cells via cleavage of proglucagon by prohormone convertase (PC)-2. In the enteroendocrine L-cell, proglucagon is differentially proce
Autor:
Ali Asadi, Rhonda D. Wideman, Travis D. Webber, Frank K. Huynh, Scott D. Covey, Streamson C. Chua, Christine McDonald, Madeleine Speck, Timothy J. Kieffer, Suraj Unniappan
Publikováno v:
Cell Metabolism. 4:291-302
The hormone leptin plays a crucial role in maintenance of body weight and glucose homeostasis. This occurs through central and peripheral pathways, including regulation of insulin secretion by pancreatic beta cells. To study this further in mice, we
Publikováno v:
Islets of Langerhans ISBN: 9789400766853
Islets of Langerhans, 2. ed. ISBN: 9789400768840
Islets of Langerhans, 2. ed. ISBN: 9789400768840
Human islet transplantation shows considerable promise as a physiological means of insulin replacement for type 1 diabetes, although donor availability and progressive loss of graft function continue to hamper more widespread implementation. Pluripot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e44808631b5f29e5b57c533974568e
https://doi.org/10.1007/978-94-007-6686-0_49
https://doi.org/10.1007/978-94-007-6686-0_49
Autor:
Masakazu Haneda, Yukihiro Fujita, Ali Asadi, Rhonda D. Wideman, David S. King, Madeleine Speck, Travis D. Webber, Timothy J. Kieffer
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 296(3)
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are released during meals from endocrine cells located in the gut mucosa and stimulate insulin secretion from pancreatic beta-cells in a glucose-dependent manner.
Autor:
Timothy J. Kieffer, Rhonda D. Wideman
Publikováno v:
Trends in endocrinology and metabolism: TEM. 20(6)
The incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), are produced predominantly by enteroendocrine cells and have multiple blood glucose-lowering effects. Recent years have seen a surge of int