Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Rhonda Bacher"'
Autor:
Evan L. Barrios, Jack R. Leary, Dijoia B. Darden, Jaimar C. Rincon, Micah Willis, Valerie E. Polcz, Gwendolyn S. Gillies, Jennifer A. Munley, Marvin L. Dirain, Ricardo Ungaro, Dina C. Nacionales, Marie-Pierre L. Gauthier, Shawn D. Larson, Laurence Morel, Tyler J. Loftus, Alicia M. Mohr, Robert Maile, Michael P. Kladde, Clayton E. Mathews, Maigan A. Brusko, Todd M. Brusko, Lyle L. Moldawer, Rhonda Bacher, Philip A. Efron
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionSepsis engenders distinct host immunologic changes that include the expansion of myeloid-derived suppressor cells (MDSCs). These cells play a physiologic role in tempering acute inflammatory responses but can persist in patients who devel
Externí odkaz:
https://doaj.org/article/c3d9f1e91fd841aa9fdb8d5f4c7a4bf1
Autor:
Melanie R. Shapiro, Xiaoru Dong, Daniel J. Perry, James M. McNichols, Puchong Thirawatananond, Amanda L. Posgai, Leeana D. Peters, Keshav Motwani, Richard S. Musca, Andrew Muir, Patrick Concannon, Laura M. Jacobsen, Clayton E. Mathews, Clive H. Wasserfall, Michael J. Haller, Desmond A. Schatz, Mark A. Atkinson, Maigan A. Brusko, Rhonda Bacher, Todd M. Brusko
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
The proportions and phenotypes of immune cell subsets in peripheral blood undergo continual and dramatic remodeling throughout the human life span, which complicates efforts to identify disease-associated immune signatures in type 1 diabetes (T1D). W
Externí odkaz:
https://doaj.org/article/637333e5554a47dcb1444963f6436280
Autor:
Laura M. Jacobsen, Kirsten Diggins, Lori Blanchfield, James McNichols, Daniel J. Perry, Jason Brant, Xiaoru Dong, Rhonda Bacher, Vivian H. Gersuk, Desmond A. Schatz, Mark A. Atkinson, Clayton E. Mathews, Michael J. Haller, S. Alice Long, Peter S. Linsley, Todd M. Brusko
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
BACKGROUND Low-dose anti–thymocyte globulin (ATG) transiently preserves C-peptide and lowers HbA1c in individuals with recent-onset type 1 diabetes (T1D); however, the mechanisms of action and features of the response remain unclear. Here, we chara
Externí odkaz:
https://doaj.org/article/ad46bb6a2d254bafb3f6b3213915a443
Autor:
Myung-Chul Kim, Nicholas Borcherding, Kawther K. Ahmed, Andrew P. Voigt, Ajaykumar Vishwakarma, Ryan Kolb, Paige N. Kluz, Gaurav Pandey, Umasankar De, Theodore Drashansky, Eric Y. Helm, Xin Zhang, Katherine N. Gibson-Corley, Julia Klesney-Tait, Yuwen Zhu, Jinglu Lu, Jinsong Lu, Xian Huang, Hongrui Xiang, Jinke Cheng, Dongyang Wang, Zheng Wang, Jian Tang, Jiajia Hu, Zhengting Wang, Hua Liu, Mingjia Li, Haoyang Zhuang, Dorina Avram, Daohong Zhou, Rhonda Bacher, Song Guo Zheng, Xuefeng Wu, Yousef Zakharia, Weizhou Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Regulatory T (Treg) cells are important modulators of the tumor microenvironment. Here the authors perform transcriptome profiling of immune cells from patients with renal clear cell carcinoma to find a Treg signature that correlates with poorer prog
Externí odkaz:
https://doaj.org/article/ce7f282daf59489b9f1d9368f3849b81
Autor:
Tyler J. Loftus, Ricardo Ungaro, Marvin Dirain, Philip A. Efron, Monty B. Mazer, Kenneth E. Remy, Richard S. Hotchkiss, Luer Zhong, Rhonda Bacher, Petr Starostik, Lyle L. Moldawer, Scott C. Brakenridge
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Both severe SARS-CoV-2 infections and bacterial sepsis exhibit an immunological dyscrasia and propensity for secondary infections. The nature of the immunological dyscrasias for these differing etiologies and their time course remain unclear. In this
Externí odkaz:
https://doaj.org/article/2ca930a417e346b6bc04c8f3b7f64748
Autor:
Dijoia B. Darden, Xiaoru Dong, Maigan A. Brusko, Lauren Kelly, Brittany Fenner, Jaimar C. Rincon, Marvin L. Dirain, Ricardo Ungaro, Dina C. Nacionales, Marie Gauthier, Michael Kladde, Todd M. Brusko, Azra Bihorac, Frederick A. Moore, Tyler Loftus, Rhonda Bacher, Lyle L. Moldawer, Alicia M. Mohr, Philip A. Efron
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundWith the successful implementation of the Surviving Sepsis Campaign guidelines, post-sepsis in-hospital mortality to sepsis continues to decrease. Those who acutely survive surgical sepsis will either rapidly recover or develop a chronic cr
Externí odkaz:
https://doaj.org/article/51a30572482c44a2b71957447ab39708
Autor:
Rhonda Bacher, Ning Leng, Li-Fang Chu, Zijian Ni, James A. Thomson, Christina Kendziorski, Ron Stewart
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background High-throughput expression profiling experiments with ordered conditions (e.g. time-course or spatial-course) are becoming more common for studying detailed differentiation processes or spatial patterns. Identifying dynamic change
Externí odkaz:
https://doaj.org/article/110d9b30efdc4b4a864f6430b8de2faa
Autor:
Dijoia B. Darden, Julie A. Stortz, McKenzie K. Hollen, Michael C. Cox, Camille G. Apple, Russell B. Hawkins, Jaimar C. Rincon, Maria-Cecilia Lopez, Zhongkai Wang, Eduardo Navarro, Jennifer E. Hagen, Hari K. Parvataneni, Maigan A. Brusko, Michael Kladde, Rhonda Bacher, Babette A. Brumback, Scott C. Brakenridge, Henry V. Baker, Christopher R. Cogle, Alicia M. Mohr, Philip A. Efron
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Older adults have significantly worse morbidity and mortality after severe trauma than younger cohorts. The competency of the innate immune response decreases with advancing age, especially after an inflammatory insult. Subsequent poor outcomes after
Externí odkaz:
https://doaj.org/article/0800739a2ae74d9f9aa89d5799441eb9
Autor:
Keshav Motwani, Leeana D. Peters, Willem H. Vliegen, Ahmed Gomaa El-sayed, Howard R. Seay, M. Cecilia Lopez, Henry V. Baker, Amanda L. Posgai, Maigan A. Brusko, Daniel J. Perry, Rhonda Bacher, Joseph Larkin, Michael J. Haller, Todd M. Brusko
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The human T lymphocyte compartment is highly dynamic over the course of a lifetime. Of the many changes, perhaps most notable is the transition from a predominantly naïve T cell state at birth to the acquisition of antigen-experienced memory and eff
Externí odkaz:
https://doaj.org/article/99b03748c4ef44f296bba8a3bcfeb3b1
Autor:
Morten Seirup, Li-Fang Chu, Srikumar Sengupta, Ning Leng, Hadley Browder, Kevin Kapadia, Christina M Shafer, Bret Duffin, Angela L Elwell, Jennifer M Bolin, Scott Swanson, Ron Stewart, Christina Kendziorski, James A Thomson, Rhonda Bacher
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239711 (2020)
As newer single-cell protocols generate increasingly more cells at reduced sequencing depths, the value of a higher read depth may be overlooked. Using data from three different single-cell RNA-seq protocols that lend themselves to having either high
Externí odkaz:
https://doaj.org/article/653545f9595e443993e4a86848c2c3b4