Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Rhodri C. Griffiths"'
1
Inhibition of UDP-Gal mutase and mycobacterial galactan biosynthesis by pyrrolidine analogues of galactofuranose
Autor: Martin D. Smith, Patrick J. Brennan, Rhodri C. Griffiths, Robert J. Nash, George W. J. Fleet, Richard E. Lee, Michael R. McNeil, Ravinder K. Grewal, Gurdyal S. Besra, Wenxin Yan
Some pyrrolidine analogues of galactofuranose - synthesised from carbohydrate lactones - are the first known inhibitors of E. coli K12 UDP-Gal mutase and mycobacterial galactan biosynthesis. This inhibition may form a new chemotherapeutic strategy fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbbd0bbf20c45ed860c631e1809bc44
https://ora.ox.ac.uk/objects/uuid:d0684791-33a6-4064-8061-54bd6354300f
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2
Glycosidase-inhibiting pyrrolidine alkaloids from Hyacinthoides non-scripta
Autor: Rhodri C. Griffiths, George W. J. Fleet, Alison A. Watson, David J. Harvey, Atsushi Kato, Eileen Lees, Stephen Dealler, Mark R. Wormald, Robert J. Nash, Andrew J. Cairns, Haruhisa Kizu, Naoki Asano
The glycosidase-inhibiting pyrrolidine alkaloids (2 R ,3 R ,4 R ,5 R )-2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine (DMDP), 2,5-dideoxy-2,5-imino- dl - glycero - d - manno -heptitol (homoDMDP), homoDMDP-7- O -apioside and 1,4-dideoxy-1,4-imino- d -ar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8127643dd7080a4a3aab561b74a331
https://ora.ox.ac.uk/objects/uuid:e448e06f-748c-4ddd-828e-459de63051cb
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3
Inhibition of fucosyl transferase and fucosidase by a rigid bicyclic mimic of alpha-L-fucose
Autor: Lucy Hackett, Keith Biggadike, George W. J. Fleet, Robert J. Nash, Bryan Winchester, Rhodri C. Griffiths, Christopher J. Britten, Kathryn H. Smelt, Annabel R. Beacham
A rigid bicyclic analogue of α-L-fucose, prepared from a monoacetonide of L-gulonolactone in an overall yield of 36% without the need for column chromatography, is a potent inhibitor of fucosidases and a weak inhibitor of a fucosyl transferase. © 1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ad67869253360231f5bda6363e8f44
https://ora.ox.ac.uk/objects/uuid:90ee2ac3-76f6-486d-a20e-c1a03f4090af
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4
2-hydroxycastanospermines (dihydroxy-L-swainsonines) from octonolactones: Inhibition of naringinase (L-rhamnosidase)
Autor: Rhodri C. Griffiths, Lea Pickering, George W. J. Fleet, Alison A. Watson, Andrew A. Bell, M.George Jones, Robert J. Nash
Short syntheses of 2S-2-hydroxycastanospermine, and 2R- and 2S-2-hydroxy-6-epicastanospermine - in which there are 6 adjacent chiral centres and 8 contiguous carbon atoms containing functional groups from eight carbon sugar lactones - depend on effic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18338ecc8054b107866e46e14aa95163
https://ora.ox.ac.uk/objects/uuid:41695ddd-b591-4268-a0c8-fcd89f29ec68
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5
Tetrazoles of manno- and rhamno-pyranoses: Contrasting inhibition of mannosidases by [4.3.0] but of rhamnosidase by [3.3.0] bicyclic tetrazoles
Autor: Bryan Winchester, Lucy Hackett, C. F. C. Smith, George W. J. Fleet, Rhodri C. Griffiths, Alison A. Watson, Benjamin G. Davis, Tilmann W. Brandstetter, Robert J. Nash
Publikováno v: Tetrahedron. 55:4489-4500
The synthesis of tetrazoles derived from D-manno and D-rhamnopyranose from L-gulonolactone and of L-rhamnopyranose from D-gulonolactone is described. These and other materials are assessed as inhibitors of glycosidases. The [4.3.0] tetrazoles of D-ma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc84160a783b31eff45048ac5a6a3282
https://doi.org/10.1016/s0040-4020(99)00137-4
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7
Enzymatic synthesis of the glycosides of calystegines B1 and B2 and their glycosidase inhibitory activities
Autor: M.George Jones, Naoki Asano, Haruhisa Kizu, Katsuhiko Matsui, Alison A. Watson, Rhodri C. Griffiths, Atsushi Kato, Robert J. Nash
Publikováno v: Carbohydrate Research. 304:173-178
Several glycosides of calystegines B1 and B2 were synthesized by use of rice alpha-glucosidase and the whole cells of Rhodotorula lactosa, and their glycosidase inhibitory activities were investigated. Incubation of mixture of calystegine B1 and malt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab294dd2d131695688f46d3b335a1fa7
https://doi.org/10.1016/s0008-6215(97)00227-9
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8
L-(+)-swainsonine and other pyrrolidine inhibitors of naringinase: Through an enzymic looking glass from D-mannosidase to L-rhamnosidase?
Autor: Robert J. Nash, Rhodri C. Griffiths, Benjamin G. Davis, C. F. C. Smith, M.George Jones, Andrew A. Bell, George W. J. Fleet, Alison A. Watson
Publikováno v: Tetrahedron Letters. 37:8565-8568
The synthesis and inhibitory properties towards naringinase (L-rhamnosidase) of L-(+)-swainsonine and of a number of more highly oxygenated analogues, and of some monocyclic equivalents, are reported. L-(+)-swainsonine and 1,4,6-trideoxy-1,4-imino-L-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8facd7a8aaa2a69b37ffc06453b9199d
https://doi.org/10.1016/0040-4039(96)01957-0
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