The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation.

Autor: Katie J Smith, Danielle Minns, Brian J McHugh, Rebecca K Holloway, Richard O'Connor, Anna Williams, Lauren Melrose, Rhoanne McPherson, Veronique E Miron, Donald J Davidson, Emily Gwyer Findlay

Publikováno v: PLoS Biology, Vol 20, Iss 8, p e3001554 (2022)

Multiple sclerosis (MS) is a highly prevalent demyelinating autoimmune condition; the mechanisms regulating its severity and progression are unclear. The IL-17-producing Th17 subset of T cells has been widely implicated in MS and in the mouse model,

Externí odkaz: https://doaj.org/article/6092c03798ea4893825a68dc61de5313

The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation

Autor: Katie J. Smith, Danielle Minns, Brian J. McHugh, Rebecca K. Holloway, Richard O’Connor, Anna Williams, Lauren Melrose, Rhoanne McPherson, Veronique E. Miron, Donald J. Davidson, Emily Gwyer Findlay

Publikováno v: Smith, K, Minns, D, McHugh, B, Holloway, R, O'Connor, R A, Williams, A C, Melrose, L, McPherson, R, Miron, V E, Davidson, D J & Gwyer Findlay, E L 2022, ' The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation ', PLoS Biology . https://doi.org/10.1371/journal.pbio.3001554

Multiple sclerosis (MS) is a highly prevalent demyelinating autoimmune condition; the mechanisms regulating its severity and progression are unclear. The IL-17-producing Th17 subset of T cells has been widely implicated in MS and in the mouse model,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177cf162efca07578b4796b727daf078
https://www.pure.ed.ac.uk/ws/files/297738163/journal.pbio.3001554.pdf

Abstract 5586: Demonstrating restoration of T cell function in exhausted T cells with IKZF3 small molecule inhibitor, Lenalidomide

Autor: Joanne Hay, Francis Acklam, Darryl Turner, Mark Barbour, Preeti Singh, Courtney Grant, Hayley Gooding, Rhoanne McPherson, Justyna Rzepecka

Publikováno v: Cancer Research. 82:5586-5586

CD8+ T cell exhaustion as a result of prolonged antigenic stimulation in the tumour microenvironment is thought to be a major mechanism by which tumours can escape immune surveillance. T cell exhaustion is characterised by co-expression of checkpoint

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02092c9394fbd6cffe775cbefe76f6a0
https://doi.org/10.1158/1538-7445.am2022-5586