Výsledky vyhledávání - "RhoA guanine nucleotide binding protein"

RhoA Pathway and Actin Regulation of the Golgi/Centriole Complex

Autor: Jarek Wosik, Malgorzata Kloc, Jacek Z. Kubiak, Ahmed Uosef, Rafik M. Ghobrial

Publikováno v: Results and Problems in Cell Differentiation ISBN: 9783030231729
The Golgi Apparatus and Centriole. Results and Problems in Cell Differentiation
The Golgi Apparatus and Centriole. Results and Problems in Cell Differentiation, 67, Springer Verlag, pp.81-93, 2019, 978-3-030-23173-6. ⟨10.1007/978-3-030-23173-6_5⟩

International audience; In vertebrate cells, the Golgi apparatus is located in close proximity to the centriole. The architecture of the Golgi/centriole complex depends on a multitude of factors, including the actin filament cytoskeleton. In turn, bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1776fd080965caf2cbeacc3e84a95fee
https://doi.org/10.1007/978-3-030-23173-6_5

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Investigation of the association between Rho/Rho-kinase gene polymorphisms and systemic sclerosis

Autor: Fatma Alibaz-Oner, Ahmet Mesut Onat, Serdar Oztuzcu, Salim Dönmez, Metin Ozgen, Süleyman Serdar Koca, Yonca Cagatay, Mehmet Sayarlioglu, Yavuz Pehlivan, Neslihan Yilmaz, Ömer Nuri Pamuk, Abdullah T. Demiryürek, Haner Direskeneli, Servet Yolbas, Gozde Yildirim Cetin, Bunyamin Kisacik

Publikováno v: Rheumatology International. 36:421-427

Demiryurek, Abdullah/0000-0003-4762-4745 WOS: 000374566000014 PubMed: 26615410 Systemic sclerosis (SSc) is a disease characterized by inflammation, vascular abnormalities and fibrosis. The role of Rho/Rho-kinase pathway was demonstrated in the pathog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528ffccd7c3b3b8ac878041c08488e76
https://doi.org/10.1007/s00296-015-3400-4

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Epigallocatechin-3-gallate reduces the proliferation of benign prostatic hyperplasia cells via regulation of focal adhesions

Autor: Burcu Erbaykent Tepedelen, Mehmet Korkmaz, Elif Soya

Publikováno v: Life sciences. 191

Aims Benign prostatic hyperplasia (BPH) is the most common urological disease that is characterized by the excessive growth of prostatic epithelial and stromal cells. Pharmacological therapy for BPH has limited use due to the many side effects so the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9855342f719fdebdd2beb43e606f993f
https://pubmed.ncbi.nlm.nih.gov/29032114

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The Cross-Talk between Canonical and Non-Canonical Wnt-Dependent Pathways Regulates P-Glycoprotein Expression in Human Blood–Brain Barrier Cells

Autor: Pierre-Olivier Couraud, Dario Antonio Ghigo, Joanna Kopecka, Chiara Riganti, Iris Chiara Salaroglio, Ruth Garzón, Martha L. Pinzon-Daza

Publikováno v: Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario

In this work, we investigate if and how transducers of the ‘canonical’ Wnt pathway, i.e., Wnt/glycogen synthase kinase 3 (GSK3)/β-catenin, and transducers of the ‘non-canonical’ Wnt pathway, i.e., Wnt/RhoA/RhoA kinase (RhoAK), cooperate to c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4fe52847fcea925f88cabdf0b43819
https://doi.org/10.1038/jcbfm.2014.100

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Central role of the exchange factor GEF-H1 in TNF-α–induced sequential activation of Rac, ADAM17/TACE, and RhoA in tubular epithelial cells

Autor: Pam Speight, Qinghong Dan, Yasaman Amoozadeh, Susumu Tanimura, Andras Kapus, Yuqian Zhang, Katalin Szászi, Faiza Waheed

Publikováno v: Molecular Biology of the Cell

Transactivation of the epidermal growth factor receptor (EGFR) by tumor necrosis factor-α (TNF-α) is a key step in mediating RhoA activation and cytoskeleton and junction remodeling in the tubular epithelium. In this study we explore the mechanisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac0d3976f5fa2dc89297dbb6df377a1
https://doi.org/10.1091/mbc.e12-09-0661

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Xenopus laevis nucleotide binding protein 1 (xNubp1) is important for convergent extension movements and controls ciliogenesis via regulation of the actin cytoskeleton

Autor: Ioannou, Androulla, Santama, Niovi, Skourides, Paris A.

Publikováno v: Developmental biology
Dev.Biol.

Nucleotide binding protein 1 (Nubp1) is a highly conserved phosphate loop (P-loop) ATPase involved in diverse processes including iron-sulfur protein assembly, centrosome duplication and lung development. Here, we report the cloning, expression and f

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https://pubmed.ncbi.nlm.nih.gov/23685253

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ProBDNF collapses neurite outgrowth of primary neurons by activating RhoA

Autor: Rainer Viktor Haberberger, Yoon Lim, Jin-Hua Zhong, Shen Liu, Ying Sun, Jian-Jun Lu, Fang Li, Xin-Fu Zhou

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 4, p e35883 (2012)

BackgroundNeurons extend their dendrites and axons to build functional neural circuits, which are regulated by both positive and negative signals during development. Brain-derived neurotrophic factor (BDNF) is a positive regulator for neurite outgrow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a29c2f954ab6a41895f4adb1243c04f
https://hdl.handle.net/1959.8/125045

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The association of statins plus LDL receptor-targeted liposome-encapsulated doxorubicin increases the in vitro drug delivery across blood-brain barrier cells

Autor: Pinzón?Daza, ML, Couraud, PO, Romero, IA, Weksler, B, Ghigo, D, Bosia, A, Riganti, C, Garzón, Ruth

Publikováno v: Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario

Background and PurposeThe passage of drugs across the blood-brain barrier (BBB) limits the efficacy of chemotherapy in brain tumours. For instance, the anticancer drug doxorubicin, which is effective against glioblastoma in vitro, has poor efficacy i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3f7fa929ebc87e64be777b9c41cb4460
http://hdl.handle.net/2318/120402

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Enhancement of learning and memory after activation of cerebral Rho GTPases

Autor: Massimo Pieri, Sara Travaglione, Giovanni Diana, Alessia Fabbri, Carla Fiorentini, Stefania Meschini, Loredana Falzano, Cristina Zona, Giovanni Valentini

The mechanism whereby the morphology and connectivity of the dendritic tree is regulated depends on an actin dynamics that, in turn, is controlled by Rho GTPases, a family of small GTP-binding proteins encompassing Rho, Rac, and Cdc42 subfamilies. Cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b18cfd7e017bfd28b308703ed3de05
http://hdl.handle.net/2108/55911

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The Gα12/13 family of heterotrimeric G proteins and the small GTPase RhoA link the Kaposi sarcoma-associated herpes virus G protein-coupled receptor to heme oxygenase-1 expression and tumorigenesis

Autor: Martín, M.J., Tanos, T., García, A.B., Martin, D., Gutkind, J.S., Coso, O.A., Marinissen, M.J.

Publikováno v: J. Biol. Chem. 2007;282(47):34510-34524
Biblioteca Digital (UBA-FCEN)
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN

Heme oxygenase-1 (HO-1), an inducible enzyme that metabolizes the heme group, is highly expressed in human Kaposi sarcoma lesions. Its expression is up-regulated by the G protein-coupled receptor from the Kaposi sarcoma-associated herpes virus (vGPCR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::f3caf20f37943e80908f87c754fa583b

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