Chronic evoked seizures in young pre-symptomatic APP/PS1 mice induce serotonin changes and accelerate onset of Alzheimer's disease-related neuropathology.

Autor: Del Pozo A; Center for Epilepsy Drug Discovery (CEDD), Department of Pharmacy, University of Washington, Seattle, WA 98195, USA., Knox KM; Center for Epilepsy Drug Discovery (CEDD), Department of Pharmacy, University of Washington, Seattle, WA 98195, USA., Lehmann LM; Center for Epilepsy Drug Discovery (CEDD), Department of Pharmacy, University of Washington, Seattle, WA 98195, USA., Davidson S; Center for Epilepsy Drug Discovery (CEDD), Department of Pharmacy, University of Washington, Seattle, WA 98195, USA., Rho SL; Center for Epilepsy Drug Discovery (CEDD), Department of Pharmacy, University of Washington, Seattle, WA 98195, USA., Jayadev S; Department of Neurology, University of Washington, Seattle, WA 98195, USA., Barker-Haliski M; Center for Epilepsy Drug Discovery (CEDD), Department of Pharmacy, University of Washington, Seattle, WA 98195, USA. Electronic address: mhaliski@uw.edu.

Publikováno v: Progress in neurobiology [Prog Neurobiol] 2024 Apr; Vol. 235, pp. 102591. Date of Electronic Publication: 2024 Mar 13.