Zobrazeno 1 - 10
of 2 824
pro vyhledávání: '"Rho GTPase"'
Autor:
Franziska C. Lammert, Julia Pannhausen, Erik Noetzel, Florian Friedland, Julia Wirtz, Yannick Herfs, Sophie Leypold, Lin Gan, Ralf Weiskirchen, Tician Schnitzler, Ruth Knüchel, Jochen Maurer, Danny D. Jonigk, Michael Rose, Nadine T. Gaisa
Publikováno v:
Molecular Oncology, Vol 18, Iss 6, Pp 1397-1416 (2024)
The effect of grainyhead‐like transcription factor 3 (GRHL3) on cancer development depends on the cancer subtypes as shown in tumor entities such as colorectal or oral squamous cell carcinomas. Here, we analyzed the subtype‐specific role of GRHL3
Externí odkaz:
https://doaj.org/article/2aaecc34605c4062b213e08b3d308c04
Autor:
Jinxuan Zheng, Rongcheng Yu, Yiqi Tang, Sihui Su, Sainan Wang, Chenxi Liao, Xuecong Li, Jiabin Liao, Dongsheng Yu, Tingting Ai, Wei Zhao, Vicky Yau, Chufeng Liu, Liping Wu, Yang Cao
Publikováno v:
Genes and Diseases, Vol 11, Iss 5, Pp 101194- (2024)
Developmental defects of enamel are common due to genetic and environmental factors before and after birth. Cdc42, a Rho family small GTPase, regulates prenatal tooth development in mice. However, its role in postnatal tooth development, especially e
Externí odkaz:
https://doaj.org/article/d21513ae3dfd4b499fbfbbf54a7150e7
Autor:
Binling Xie, Jiaxin Liang, Jifan Jiang, Ting Zeng, Ling Liu, Dinghua Xie, Ganghua Zhu, Lei Xiong, Kanjia Zhang, Dong Liu, Jie Gong, Xiangding Chen, Ruosha Lai, Huaping Xie
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Introductionmyo7aa, the homolog of the human Usher 1B syndrome pathogenic gene, myo7A, plays an important role in stereociliary development and maintenance, therefore, is critical for hearing and balance. However, the molecular mechanisms that myo7aa
Externí odkaz:
https://doaj.org/article/b3d9c526eb04499788a4adbff4caca40
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 4, Pp 151453- (2024)
Human circulating monocytes are established targets for Zika virus (ZIKV) infection. Because of their important migratory properties toward any tissues, including the central nervous system (CNS), a better understanding of the mechanisms underlying m
Externí odkaz:
https://doaj.org/article/0bb06402904f45c59e5004a517fedf69
Autor:
Katerina Mardilovich, Gregory Naylor, Linda Julian, Narisa Phinichkusolchit, Karen Keeshan, Karen Blyth, Michael F. Olson
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/48c60a7914734ffa8fb50ad8a03f0b2c
Autor:
Siarhei Hladyshau, Kaiyun Guan, Nivedita Nivedita, Beverly Errede, Denis Tsygankov, Timothy C. Elston
Publikováno v:
Cells, Vol 13, Iss 16, p 1358 (2024)
Cell polarity refers to the asymmetric distribution of proteins and other molecules along a specified axis within a cell. Polarity establishment is the first step in many cellular processes. For example, directed growth or migration requires the form
Externí odkaz:
https://doaj.org/article/82fdabb893754399bcbd11ad374eae0f
Autor:
Harry Cheuk-Hay Lau, Xiang Zhang, Fenfen Ji, Yufeng Lin, Wei Liang, Qing Li, Danyu Chen, Winnie Fong, Xing Kang, Weixin Liu, Eagle Siu-Hong Chu, Queena Wing-Yin Ng, Jun Yu
Publikováno v:
EBioMedicine, Vol 100, Iss , Pp 104952- (2024)
Summary: Background: Gut probiotic depletion is associated with non-alcoholic fatty liver disease-associated hepatocellular carcinoma (NAFLD-HCC). Here, we investigated the prophylactic potential of Lactobacillus acidophilus against NAFLD-HCC. Method
Externí odkaz:
https://doaj.org/article/d1a496c71a364cbb9bf0c5d16230342a
Publikováno v:
Gut and Liver, Vol 17, Iss 5, Pp 741-752 (2023)
Background/Aims: Altered DNA methylation is a key mechanism of epigenetic modification in gastric cancer (GC). This study aimed to evaluate the changes in epigenetic and genetic expression of multiple Rho GTPases in Helicobacter pylori-related gastri
Externí odkaz:
https://doaj.org/article/a5b2c6e3bb174296b55cd7fcd9589ffe
Autor:
Yueyang Wang, Lee D Troughton, Fan Xu, Aritra Chatterjee, Chang Ding, Han Zhao, Laura P Cifuentes, Ryan B Wagner, Tianqi Wang, Shelly Tan, Jingjuan Chen, Linlin Li, David Umulis, Shihuan Kuang, Daniel M Suter, Chongli Yuan, Deva Chan, Fang Huang, Patrick W Oakes, Qing Deng
Publikováno v:
eLife, Vol 12 (2023)
Cell spreading and migration play central roles in many physiological and pathophysiological processes. We have previously shown that MFN2 regulates the migration of human neutrophil-like cells via suppressing Rac activation. Here, we show that in mo
Externí odkaz:
https://doaj.org/article/80d2f4bf1af140f981ecc2ce933a1e23
Autor:
Yan Zhang, Zhengru Zhu, Yang Cao, Zhenyu Xiong, Yu Duan, Jie Lin, Xuebin Zhang, Mengyuan Jiang, Yue Liu, Wanrong Man, Tengfei Jia, Jiaxu Feng, Yanyan Chen, Congye Li, Baolin Guo, Dongdong Sun
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 9, Pp n/a-n/a (2023)
Abstract Background As the main pathological basis for various cardiovascular and cerebrovascular diseases, atherosclerosis has become one of the leading causes of death and disability worldwide. Emerging evidence has suggested that Rho GTPase Rnd3 p
Externí odkaz:
https://doaj.org/article/0e0685ace32345709f77fe3ce2e97086