Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rhiannon Thomas-Tran"'
Autor:
Dillon H. Miles, Ada Chen, Manmohan Reddy Leleti, Divyank Soni, Stephen W Young, Artur K. Mailyan, Kenneth V. Lawson, Stefan G Shaqfeh, Ehesan U. Sharif, Pei-Yu Chen, Jenna L. Jeffrey, Jesus Banuelos, Xuelei Yan, Samuel L Drew, Nigel Walker, Puja Dhanota, Lixia Jin, Jay P. Powers, Elaine Ginn, Guillaume Mata, Kent Wong, Jeremy Fournier, Joel W. Beatty, Rhiannon Thomas-Tran, Ulrike Schindler, Amber Pham, Matthew J. Walters, Jie Chen, Cesar Meleza, Xiaoning Zhao
Publikováno v:
Journal of Medicinal Chemistry. 63:11235-11257
The selective inhibition of the lipid signaling enzyme PI3Kγ constitutes an opportunity to mediate immunosuppression and inflammation within the tumor microenvironment but is difficult to achieve due to the high sequence homology across the class I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237c477c3969b94ce636dfc76aca3e4f
https://doi.org/10.1021/acs.jmedchem.0c01203
https://doi.org/10.1021/acs.jmedchem.0c01203
Autor:
Stephen W Young, Debashis Mandal, Sharon Zhao, Susanne Moschütz, Ada Chen, Elaine Ginn, Lixia Jin, Samuel L Drew, Nigel Walker, Erick Allen Lindsey, Jay P. Powers, Kenneth V. Lawson, Xuelei Yan, Anh Tran, Rhiannon Thomas-Tran, Amber Pham, Manmohan Reddy Leleti, Jenna L. Jeffrey, Steven D. Jacob, Norbert Sträter, Joel W. Beatty, Jeremy Fournier, Laurent Debien
Publikováno v:
Journal of Medicinal Chemistry. 63:3935-3955
CD73 is an extracellular mediator of purinergic signaling. When upregulated in the tumor microenvironment, CD73 has been implicated in the inhibition of immune function through overproduction of adenosine. Traditional efforts to inhibit CD73 have inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb1d479ddd330a628c6dc7fec984840
https://doi.org/10.1021/acs.jmedchem.9b01713
https://doi.org/10.1021/acs.jmedchem.9b01713
Publikováno v:
Science Advances
Science advances, vol 5, iss 6
Science advances, vol 5, iss 6
Bullfrog saxiphilin:STX complex defines a toxin “molecular sponge” blueprint for STX recognition and toxin resistance.
Dinoflagelates and cyanobacteria produce saxitoxin (STX), a lethal bis-guanidinium neurotoxin causing paralytic shellfish
Dinoflagelates and cyanobacteria produce saxitoxin (STX), a lethal bis-guanidinium neurotoxin causing paralytic shellfish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a533007c067f56bed0615670119c5370
https://pubmed.ncbi.nlm.nih.gov/31223657
https://pubmed.ncbi.nlm.nih.gov/31223657
The bis-guanidinium toxins are a collection of natural products that display nanomolar potency against select isoforms of eukaryotic voltage-gated Na+ ion channels. We describe a synthetic strategy that enables access to four of these poisons, namely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0b98a57ead64ff443c441a052be5bb
https://europepmc.org/articles/PMC6426452/
https://europepmc.org/articles/PMC6426452/
Autor:
J. Du Bois, Rhiannon Thomas-Tran
Publikováno v:
Proceedings of the National Academy of Sciences. 113:5856-5861
Improper function of voltage-gated sodium channels (Na V s), obligatory membrane proteins for bioelectrical signaling, has been linked to a number of human pathologies. Small-molecule agents that target Na V s hold considerable promise for treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fbe5c0eb68c697a387b123a3bd7602a
https://doi.org/10.1073/pnas.1603486113
https://doi.org/10.1073/pnas.1603486113
Autor:
Merritt Maduke, Chase Wood, Jonas Almqvist, J. Du Bois, Anna K. Koster, Tanmay S. Chavan, Rhiannon Thomas-Tran, Kee-Hyun Choi
Publikováno v:
Proceedings of the National Academy of Sciences. 115
CLC proteins are a ubiquitously expressed family of chloride-selective ion channels and transporters. A dearth of pharmacological tools for modulating CLC gating and ion conduction limits investigations aimed at understanding CLC structure/function a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb13f08d6b1f44b73d9938801a40aa20
https://doi.org/10.1073/pnas.1720584115
https://doi.org/10.1073/pnas.1720584115
Publikováno v:
Science (New York, N.Y.). 354(6314)
Pluses and minuses of BTX behavior Batrachotoxin is a potent neurotoxin produced by the endangered Colombian poison dart frog and is an agonist of voltage-gated sodium ion channels (NaVs). Logan et al. developed a chemical synthesis of this molecule,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b172e986d442f7d1d08c8cd2b654188
https://pubmed.ncbi.nlm.nih.gov/27856903
https://pubmed.ncbi.nlm.nih.gov/27856903
Autor:
Kee-Hyun Choi, Anna K. Koster, Justin Du Bois, Merritt Maduke, Jonas Almqvist, Rhiannon Thomas-Tran, Tanmay S. Chavan, Chase Wood
Publikováno v:
Biophysical Journal. 112:339a
The chloride channel (CLC) family is a class of membrane proteins that regulates the flux of chloride ions across cell membranes. Two of the nine mammalian CLC isoforms, CLC-Ka and CLC-Kb, reside in the kidney where they are critical for maintaining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::331028b53c78fa1edceefa975aa0c888
https://doi.org/10.1016/j.bpj.2016.11.1836
https://doi.org/10.1016/j.bpj.2016.11.1836