The Trans Influence in Unsymmetrical Pincer Palladacycles: An Experimental and Computational Study

Autor: Sarote Boonseng, Gavin W. Roffe, Rhiannon N. Jones, Graham J. Tizzard, Simon J. Coles, John Spencer, Hazel Cox

Publikováno v: Inorganics, Vol 4, Iss 3, p 25 (2016)

A library of unsymmetrical SCN pincer palladacycles, [ClPd{2-pyr-6-(RSCH2)C6H3}], R = Et, Pr, Ph, p-MePh, and p-MeOPh, pyr = pyridine, has been synthesized via C–H bond activation, and used, along with PCN and N’CN unsymmetrical pincer palladacyc

Externí odkaz: https://doaj.org/article/e8048e389f564389b25214ed7d8384ed

Genotoxicity and Epigenotoxicity of Carbazole-Derived Molecules on MCF-7 Breast Cancer Cells

Autor: Andreas C. Joerger, Rossella Branni, Ilenia Cruciata, Fabio Caradonna, Raysa Khan Tareque, Rossella Bellina, Carol Austin, Cory A. Ocasio, Pietro D Oca, Tiziana Ferrara, Martin Walker, Mark C. Bagley, Claudio Luparello, Rhiannon N. Jones, John Spencer

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 3410, p 3410 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 7

The carbazole compounds PK9320 (1-(9-ethyl-7-(furan-2-yl)-9H-carbazol-3-yl)-N-methylmethanamine) and PK9323 (1-(9-ethyl-7-(thiazol-4-yl)-9H-carbazol-3-yl)-N-methylmethanamine), second-generation analogues of PK083 (1-(9-ethyl-9H-carbazol-3-yl)-N-meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d31c6f019e685c32e3146ea342d8ef
https://doi.org/10.3390/ijms22073410

Pojamide: An HDAC3-selective ferrocene analogue with remarkably enhanced redox-triggered ferrocenium activity in cells

Autor: Nikolaos Tsoureas, Simon J. Coles, Graham J. Tizzard, Rhiannon N. Jones, Thomas G. Scott, James E. Bradner, Cory A. Ocasio, Peter Coxhead, James Spencer, Justin M. Roberts, Supojjanee Sansook, Helfrid Hochegger, Matthew Guille

Publikováno v: Ocasio, C A, Sansook, S, Jones, R, Roberts, J M, Scott, T G, Tsoureas, N, Coxhead, P, Guille, M, Tizzard, G J, Coles, S J, Hochegger, H, Bradner, J E & Spencer, J 2017, ' Pojamide : an HDAC3-selective ferrocene analogue with remarkably enhanced redox-triggered ferrocenium activity in cells ', Organometallics . https://doi.org/10.1021/acs.organomet.7b00437

A ferrocene containing o-aminoanilide, N1-(2-aminophenyl)-N8-ferrocenyloctanediamide (2b, Pojamide) displayed nanomolar potency vs HDAC3. In comparison to RGFP966, a potent and selective HDAC3 inhibitor, Pojamide displayed superior activity in HCT116

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3740e6c7b657bbf89c178144ecc0e6e
https://eprints.soton.ac.uk/413525/

A synthetic, catalytic and theoretical investigation of an unsymmetrical SCN pincer palladacycle

Autor: Sarote Boonseng, Neil John Press, Christine B. Baltus, Gavin W. Roffe, Simon J. Coles, Mario Ruiz, Rhiannon N. Jones, John Spencer, Hazel Cox, Iain J. Day, Graham J. Tizzard

Publikováno v: Royal Society Open Science, Vol 3, Iss 4 (2016)
Royal Society Open Science
ResearcherID

The SCN ligand 2-{3-[(methylsulfanyl)methyl]phenyl}pyridine, 1, has been synthesized starting from an initial Suzuki–Miyaura (SM) coupling between 3-((hydroxymethyl)phenyl)boronic acid and 2-bromopyridine. The C–H activation of 1 with in situ for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::261f157cb9c340fd4f561601102277c1
https://eprints.soton.ac.uk/402104/