Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Rhiannon N Hardwick"'
Autor:
Alicia Y. Lim, Yuki Kato, Courtney Sakolish, Alan Valdiviezo, Gang Han, Piyush Bajaj, Jason Stanko, Stephen S. Ferguson, Remi Villenave, Philip Hewitt, Rhiannon N. Hardwick, Ivan Rusyn
Publikováno v:
Bioengineering, Vol 10, Iss 10, p 1195 (2023)
The liver is one of the key organs for exogenous and endogenous metabolism and is often a target for drug- and chemical-driven toxicity. A wide range of experimental approaches has been established to model and characterize the mechanisms of drug- an
Externí odkaz:
https://doaj.org/article/a18304e2256b45029ba33d462bd66feb
Autor:
Ivan Rusyn, Courtney Sakolish, Yuki Kato, Clifford Stephan, Leoncio Vergara, Philip Hewitt, Vasanthi Bhaskaran, Myrtle Davis, Rhiannon N Hardwick, Stephen S Ferguson, Jason P Stanko, Piyush Bajaj, Karissa Adkins, Nisha S Sipes, E Sidney Hunter, Maria T Baltazar, Paul L Carmichael, Kritika Sadh, Richard A Becker
Publikováno v:
Toxicol Sci
Much has been written and said about the promise and excitement of microphysiological systems, miniature devices that aim to recreate aspects of human physiology on a chip. The rapid explosion of the offerings and persistent publicity placed high exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5fe00b5247331ff1b276233e30fd420
https://pubmed.ncbi.nlm.nih.gov/35689632
https://pubmed.ncbi.nlm.nih.gov/35689632
Publikováno v:
ADMET and DMPK, Vol 4, Iss 4, Pp 302-313 (2016)
Tyrosine and aurora kinases are important effectors in signal transduction pathways that are often involved in aberrant cancer cell growth. Tyrosine (TKI) and aurora (AKI) kinase inhibitors are anti-cancer agents specifically designed to target such
Externí odkaz:
https://doaj.org/article/51a8a10f0f3b47b196b087d93fcf53be
Autor:
Rhiannon N Hardwick, Patrick Brassil, Ilaria Badagnani, Kimberly Perkins, Glenmar P Obedencio, Andrea S Kim, Michael W Conner, David L Bourdet, Eric B Harstad
Publikováno v:
Toxicological Sciences. 186:323-337
Izencitinib (TD-1473), an oral, gut-selective pan-Janus kinase (JAK) inhibitor under investigation for treatment of inflammatory bowel diseases, was designed for optimal efficacy in the gastrointestinal tract while minimizing systemic exposures and J
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030ba42d630b8c4a983f810d39f6dd81
https://doi.org/10.1093/toxsci/kfac002
https://doi.org/10.1093/toxsci/kfac002
Autor:
Jessica Whritenour, Rhiannon N. Hardwick, Catherine J. Betts, Maike Thamsen, Radhakrishna Sura, Kristin M. Fabre, Elad H. Kaufman
Publikováno v:
Lab on a Chip. 20:199-214
Skin is the largest organ of the body and serves as the principle barrier to the environment. Composed of multiple cell types arranged in stratified layers with highly specialized appendages, it serves sensory and immune surveillance roles in additio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80dfc071343eaf8f78bad1d63f87da94
https://doi.org/10.1039/c9lc00519f
https://doi.org/10.1039/c9lc00519f
Autor:
Xiaoting, Wang, Anna K, Kopec, Mark, Collinge, Rhiannon, David, Christian, Grant, Rhiannon N, Hardwick, Aaron, Navratil, Nirav, Patel, Wendy, Rowan, Nikki, Marshall
Publikováno v:
ALTEX.
Immune responses are heavily involved in the regulation and pathogenesis of human diseases, including infectious diseases, inflammatory and autoimmune conditions, cancer, neurological disorders and cardiometabolic syndromes. The immune system has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f5111251a971a4344f5cc1a52980a2
https://doi.org/10.14573/altex.2205311
https://doi.org/10.14573/altex.2205311
Autor:
Szczepan W, Baran, Paul C, Brown, Andreas R, Baudy, Suzanne C, Fitzpatrick, Christopher, Frantz, Aaron, Fullerton, Jinping, Gan, Rhiannon N, Hardwick, Kathleen M, Hillgren, Anna K, Kopec, Jennifer L, Liras, Donna L, Mendrick, Ryan, Nagao, William R, Proctor, Diane, Ramsden, Alexandre J S, Ribeiro, David, Stresser, Kyung E, Sung, Radhakrishna, Sura, Kazuhiro, Tetsuka, Lindsay, Tomlinson, Terry, Van Vleet, Matthew P, Wagoner, Qin, Wang, Sevim Yildiz, Arslan, Gorm, Yoder, Jason E, Ekert
Publikováno v:
ALTEX.
Complex in vitro models (CIVM) offer the potential to improve pharmaceutical clinical drug attrition due to safety and/ or efficacy concerns. For this technology to have an impact, the establishment of robust characterization and qualification plan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991b82190055f9a932fb29fb1692bafd
https://doi.org/10.14573/altex.2112203
https://doi.org/10.14573/altex.2112203
Publikováno v:
Stem Cell Reports
This commentary presents a thought experiment seeking to answer the key question: “If you were to put aside all the traditional drug discovery processes and start a new drug discovery program that places the highest priority on human and disease-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c31156501c861465f6f4569d28a01ed
https://pubmed.ncbi.nlm.nih.gov/34525380
https://pubmed.ncbi.nlm.nih.gov/34525380
Autor:
Nathan J. Cherrington, Rhiannon N. Hardwick, Jeremy K. Nicholson, Alexandros Pechlivanis, Lesley Hoyles, Ian D. Wilson, Kate Wolfer, Marine P.M. Letertre, Nyasha Munjoma, Muireann Coen, Julie A. K. McDonald, Jonathan R. Swann
Publikováno v:
Journal of Proteome Research
Methotrexate (MTX) is a chemotherapeutic agent that can cause a range of toxic side effects including gastrointestinal damage, hepatotoxicity, myelosuppression, and nephrotoxicity and has potentially complex interactions with the gut microbiome. Foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b37bb4ebf00b021aba3621ff3dd82a1
https://eprints.soton.ac.uk/443724/
https://eprints.soton.ac.uk/443724/
Publikováno v:
Liver International. 37:1074-1081
Background & Aims N-linked glycosylation of proteins is critical for proper protein folding and trafficking to the plasma membrane. Drug transporters are one class of proteins that have reduced function when glycosylation is impaired. N-linked glycos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ef8dd24e7265da1b5fbb42c02b7410
https://doi.org/10.1111/liv.13362
https://doi.org/10.1111/liv.13362