Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Rhiannon M Meredith"'
Autor:
Aishwarya G Nadadhur, Javier Emperador Melero, Marieke Meijer, Desiree Schut, Gerbren Jacobs, Ka Wan Li, J J Johannes Hjorth, Rhiannon M Meredith, Ruud F Toonen, Ronald E Van Kesteren, August B Smit, Matthijs Verhage, Vivi M Heine
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178533 (2017)
Generation of neuronal cultures from induced pluripotent stem cells (hiPSCs) serve the studies of human brain disorders. However we lack neuronal networks with balanced excitatory-inhibitory activities, which are suitable for single cell analysis. We
Externí odkaz:
https://doaj.org/article/f7a60a49989a499583822389b705e4bf
Autor:
Guilherme Testa-Silva, Matthijs B Verhoog, Daniele Linaro, Christiaan P J de Kock, Johannes C Baayen, Rhiannon M Meredith, Chris I De Zeeuw, Michele Giugliano, Huibert D Mansvelder
Publikováno v:
PLoS Biology, Vol 12, Iss 11, p e1002007 (2014)
Neuronal firing, synaptic transmission, and its plasticity form the building blocks for processing and storage of information in the brain. It is unknown whether adult human synapses are more efficient in transferring information between neurons than
Externí odkaz:
https://doaj.org/article/9d69cd699b934365ad539fdbc5d4baf5
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 6, p e1002545 (2012)
CA1 pyramidal neurons receive hundreds of synaptic inputs at different distances from the soma. Distance-dependent synaptic scaling enables distal and proximal synapses to influence the somatic membrane equally, a phenomenon called "synaptic democrac
Externí odkaz:
https://doaj.org/article/d26edc7327ae4506970c8bf5b055ed67
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 2 (2010)
Development of cognitive function requires the formation and refinement of synaptic networks of neurons in the brain. Morphological abnormalities of synaptic spines occur throughout the brain in a wide variety of syndromic and non-syndromic disorders
Externí odkaz:
https://doaj.org/article/c501e28603154ec484fa9673492788ee
Autor:
L Niels Cornelisse, Ronald A J van Elburg, Rhiannon M Meredith, Rafael Yuste, Huibert D Mansvelder
Publikováno v:
PLoS ONE, Vol 2, Iss 10, p e1073 (2007)
Rapid calcium concentration changes in postsynaptic structures are crucial for synaptic plasticity. Thus far, the determinants of postsynaptic calcium dynamics have been studied predominantly based on the decay kinetics of calcium transients. Calcium
Externí odkaz:
https://doaj.org/article/8462090b363e44cca5b8157a7029284a
Autor:
Ioannis Kramvis, Rhodé van Westen, Hanna C. A. Lammertse, Danai Riga, Tim S. Heistek, Alex Loebel, Sabine Spijker, Huibert D. Mansvelder, Rhiannon M. Meredith
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Changes in excitation and inhibition are associated with the pathobiology of neurodevelopmental disorders of intellectual disability and autism and are widely described in Fragile X syndrome (FXS). In the prefrontal cortex (PFC), essential for cognit
Externí odkaz:
https://doaj.org/article/693380dca7b24a30a1210680191262f2
Autor:
Tim S. Heistek, Ioannis Kramvis, Sabine Spijker, Alex Loebel, Danai Riga, Huibert D. Mansvelder, Hanna C.A. Lammertse, Rhodé van Westen, Rhiannon M. Meredith
Publikováno v:
Kramvis, I, van Westen, R, Lammertse, H C A, Riga, D, Heistek, T S, Loebel, A, Spijker, S, Mansvelder, H D & Meredith, R M 2020, ' Dysregulated Prefrontal Cortex Inhibition in Prepubescent and Adolescent Fragile X Mouse Model ', Frontiers in Molecular Neuroscience, vol. 13, no. May, 88, pp. 1-16 . https://doi.org/10.3389/fnmol.2020.00088
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, 13(May):88, 1-16. Frontiers Media S.A.
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, 13(May):88, 1-16. Frontiers Media S.A.
Changes in excitation and inhibition are associated with the pathobiology of neurodevelopmental disorders of intellectual disability and autism and are widely described in Fragile X syndrome (FXS). In the prefrontal cortex (PFC), essential for cognit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68db8190bf90f22a2eed5578d5452d17
https://doi.org/10.3389/fnmol.2020.00088
https://doi.org/10.3389/fnmol.2020.00088
Autor:
Ana R.A.A. Quadros, Rocío Díez Arazola, Andrea Romaguera Álvarez, Johny Pires, Rhiannon M. Meredith, Ingrid Saarloos, Matthijs Verhage, Ruud F. Toonen
Publikováno v:
iScience, 25(4):104069. Elsevier Inc.
Quadros, A R A A, Arazola, R D, Álvarez, A R, Pires, J, Meredith, R M, Saarloos, I, Verhage, M & Toonen, R F 2022, ' Neuronal F-Box protein FBXO41 regulates synaptic transmission and hippocampal network maturation ', iScience, vol. 25, no. 4, 104069, pp. 1-18 . https://doi.org/10.1016/j.isci.2022.104069
Quadros, A R A A, Arazola, R D E, Álvarez, A R, Pires, J, Meredith, R M, Saarloos, I, Verhage, M & Toonen, R F 2022, ' Neuronal F-Box protein FBXO41 regulates synaptic transmission and hippocampal network maturation ', iScience, vol. 25, no. 4, 104069 . https://doi.org/10.1016/j.isci.2022.104069
iScience, 25(4):104069, 1-18. Elsevier
Quadros, A R A A, Arazola, R D, Álvarez, A R, Pires, J, Meredith, R M, Saarloos, I, Verhage, M & Toonen, R F 2022, ' Neuronal F-Box protein FBXO41 regulates synaptic transmission and hippocampal network maturation ', iScience, vol. 25, no. 4, 104069, pp. 1-18 . https://doi.org/10.1016/j.isci.2022.104069
Quadros, A R A A, Arazola, R D E, Álvarez, A R, Pires, J, Meredith, R M, Saarloos, I, Verhage, M & Toonen, R F 2022, ' Neuronal F-Box protein FBXO41 regulates synaptic transmission and hippocampal network maturation ', iScience, vol. 25, no. 4, 104069 . https://doi.org/10.1016/j.isci.2022.104069
iScience, 25(4):104069, 1-18. Elsevier
FBXO41 is a neuron-specific E3 ligase subunit implicated in epileptic encephalopathies. Fbxo41 null mutant (KO) mice show behavioral deficits and early lethality. Here, we report that loss of FBXO41 causes defects in synaptic transmission and brain d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2beabfa7e1ed6c9cc688b5287c862d
https://pubmed.ncbi.nlm.nih.gov/35372812
https://pubmed.ncbi.nlm.nih.gov/35372812
Publikováno v:
Developmental Neurobiology
Pires, J, Nelissen, R, Mansvelder, H D & Meredith, R M 2021, ' Spontaneous synchronous network activity in the neonatal development of mPFC in mice ', Developmental Neurobiology, vol. 81, no. 2, pp. 207-225 . https://doi.org/10.1002/dneu.22811
Developmental Neurobiology, 81(2), 207-225. John Wiley and Sons Inc.
Pires, J, Nelissen, R, Mansvelder, H D & Meredith, R M 2021, ' Spontaneous synchronous network activity in the neonatal development of mPFC in mice ', Developmental Neurobiology, vol. 81, no. 2, pp. 207-225 . https://doi.org/10.1002/dneu.22811
Developmental Neurobiology, 81(2), 207-225. John Wiley and Sons Inc.
Spontaneous Synchronous Network Activity (SSA) is a hallmark of neurodevelopment found in numerous central nervous system structures, including neocortex. SSA occurs during restricted developmental time-windows, commonly referred to as critical perio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e08a8f2fc3fe772d2268f013a8d6407
https://pubmed.ncbi.nlm.nih.gov/33453138
https://pubmed.ncbi.nlm.nih.gov/33453138
Publikováno v:
Dawitz, J, Kroon, T, Hjorth, J J J, Mansvelder, H D & Meredith, R M 2020, ' Distinct Synchronous Network Activity During the Second Postnatal Week of Medial Entorhinal Cortex Development ', Frontiers in Cellular Neuroscience, vol. 14, 91, pp. 1-14 . https://doi.org/10.3389/fncel.2020.00091
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Frontiers in Cellular Neuroscience, 14:91, 1-14. Frontiers Media S.A.
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Frontiers in Cellular Neuroscience, 14:91, 1-14. Frontiers Media S.A.
Frontiers in Cellular Neuroscience
The medial entorhinal cortex (MEC) contains specialized cell types whose firing is tuned to aspects of an animal’s position and orientation in the environment, reflecting a neuronal representation of space. The spatially tuned firing properties of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae5d45f674399308f094ec4a63db327