Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Rhiannon E, Jones"'
Autor:
Helene E B Geiller, Adam Harvey, Rhiannon E Jones, Julia W Grimstead, Kez Cleal, Eric A Hendrickson, Duncan M Baird
Publikováno v:
PLoS Genetics, Vol 18, Iss 11, p e1010485 (2022)
Telomerase activity is the principal telomere maintenance mechanism in human cancers, however 15% of cancers utilise a recombination-based mechanism referred to as alternative lengthening of telomeres (ALT) that leads to long and heterogenous telomer
Externí odkaz:
https://doaj.org/article/c81ea65d1fdd4e569bfe1d5f11bd2374
Autor:
Raya Ahmed, Kelly L. Miners, Julio Lahoz-Beneytez, Rhiannon E. Jones, Laureline Roger, Christina Baboonian, Yan Zhang, Eddie C.Y. Wang, Marc K. Hellerstein, Joseph M. McCune, Duncan M. Baird, David A. Price, Derek C. Macallan, Becca Asquith, Kristin Ladell
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108501- (2020)
Summary: A central paradigm in the field of lymphocyte biology asserts that replicatively senescent memory T cells express the carbohydrate epitope CD57. These cells nonetheless accumulate with age and expand numerically in response to persistent ant
Externí odkaz:
https://doaj.org/article/7885536d2b5e42149b0d76509a9181e5
Autor:
Isabel Garcia-Martin, Richard J. A. Penketh, Samantha M. Garay, Rhiannon E. Jones, Julia W. Grimstead, Duncan M. Baird, Rosalind M. John
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7458 (2021)
Background. Depression is a common mood disorder during pregnancy impacting one in every seven women. Children exposed to prenatal depression are more likely to be born at a low birth weight and develop chronic diseases later in life. A proposed hypo
Externí odkaz:
https://doaj.org/article/d39eb8d5f59e44f1be6b85fc0c496023
Autor:
Meera Adishesh, Rafah Alnafakh, Duncan M. Baird, Rhiannon E. Jones, Shannon Simon, Lucy Button, Areege M. Kamal, John Kirwan, S. Bridget DeCruze, Josephine Drury, Gabriele Saretzki, Dharani K. Hapangama
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8686 (2020)
Telomeres are transcribed as long non-coding RNAs called TERRAs (Telomeric repeat containing RNA) that participate in a variety of cellular regulatory functions. High telomerase activity (TA) is associated with endometrial cancer (EC). This study aim
Externí odkaz:
https://doaj.org/article/fa457dbbff304c2ead82fc0595242046
Autor:
Elisa Aquilanti, Lauren Kageler, Jacqueline Watson, Duncan M Baird, Rhiannon E Jones, Marie Hodges, Zsofia M Szegletes, John G Doench, Craig A Strathdee, Jose Ricardo Mc Faline Figueroa, Keith L Ligon, Matthew Beck, Patrick Y Wen, Matthew Meyerson
Publikováno v:
Neuro-Oncology.
BackgroundGlioblastoma is one of the most lethal forms of cancer, with 5-year survival rates of only 6%. Glioblastoma-targeted therapeutics have been challenging to develop due to significant inter- and intra-tumoral heterogeneity. Telomerase reverse
Autor:
Pedro Costa Del Amo, Julio Lahoz-Beneytez, Lies Boelen, Raya Ahmed, Kelly L Miners, Yan Zhang, Laureline Roger, Rhiannon E Jones, Silvia A Fuertes Marraco, Daniel E Speiser, Duncan M Baird, David A Price, Kristin Ladell, Derek Macallan, Becca Asquith
Publikováno v:
PLoS Biology, Vol 16, Iss 6, p e2005523 (2018)
Adaptive immunity relies on the generation and maintenance of memory T cells to provide protection against repeated antigen exposure. It has been hypothesised that a self-renewing population of T cells, named stem cell-like memory T (TSCM) cells, are
Externí odkaz:
https://doaj.org/article/c85bfaa7e2db4200835697b9df1f03c9
Autor:
Isabel Garcia-Martin, Richard J A Penketh, Anna B Janssen, Rhiannon E Jones, Julia Grimstead, Duncan M Baird, Rosalind M John
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208533 (2018)
Shortened leukocyte and placental telomeres associated with gestational diabetes mellitus (GDM) suggest this exposure triggers telomere attrition contributing to adverse outcomes. We applied high resolution Single Telomere Length Analysis (STELA) to
Externí odkaz:
https://doaj.org/article/52d37c8906114d0d9efae839258b31ef
Autor:
Boitelo T Letsolo, Rhiannon E Jones, Jan Rowson, Julia W Grimstead, W Nicol Keith, Gareth J S Jenkins, Duncan M Baird
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174833 (2017)
Barrett's oesophagus is a premalignant metaplastic condition that predisposes patients to the development of oesophageal adenocarcinoma. However, only a minor fraction of Barrett's oesophagus patients progress to adenocarcinoma and it is thus essenti
Externí odkaz:
https://doaj.org/article/d8f9b80fd6ea4b6196df8cda58935a64
Autor:
Rhiannon E. Jones, Sehyun Oh, Julia W. Grimstead, Jacob Zimbric, Laureline Roger, Nicole H. Heppel, Kevin E. Ashelford, Kate Liddiard, Eric A. Hendrickson, Duncan M. Baird
Publikováno v:
Cell Reports, Vol 8, Iss 4, Pp 1063-1076 (2014)
Short dysfunctional telomeres are capable of fusion, generating dicentric chromosomes and initiating breakage-fusion-bridge cycles. Cells that escape the ensuing cellular crisis exhibit large-scale genomic rearrangements that drive clonal evolution a
Externí odkaz:
https://doaj.org/article/74ca282653444cada7d066278696395b
Autor:
Duncan M. Baird, Rosalind M. John, Isabel Garcia-Martin, Samantha M. Garay, Rhiannon E. Jones, Richard Penketh, Julia W. Grimstead
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 14
International Journal of Molecular Sciences, Vol 22, Iss 7458, p 7458 (2021)
Volume 22
Issue 14
International Journal of Molecular Sciences, Vol 22, Iss 7458, p 7458 (2021)
Background. Depression is a common mood disorder during pregnancy impacting one in every seven women. Children exposed to prenatal depression are more likely to be born at a low birth weight and develop chronic diseases later in life. A proposed hypo